MEROPS the Database of Proteolytic Enzymes, their Substrates and Inhibitors

Release 12.3

The Inhibitors Side of MEROPS

In biology, the balance between peptidases and their inhibitors is commonly of the greatest importance, and MEROPS provides information on the inhibitors of peptidases as well as the enzymes themselves.

As with peptidases, the page of the database describing each protein inhibitor can be found by searching one of three indexes for its Name, MEROPS Identifier or source Organism, and the inhibitors are assigned to families and clans in much the same way as the peptidases. As usual, MEROPS provides sequence alignments, trees and literature files.

In addition to the protein inhibitors, there are small-molecule inhibitors of peptidases that are of great importance as reagents in research or as drugs. A separate index is provided for access to information on these.

Please use the side-bar Menu to navigate through the inhibitors side of MEROPS.

Use us and cite us!

Many authors find it useful to include data from MEROPS in their publications, and that is very much what we are here for, but please cite the appropriate publication as well as the URL when you do so. This is: Rawlings, N.D., Barrett, A.J., Thomas, P.D., Huang, X., Bateman, A. & Finn, R.D. (2018) The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database. Nucleic Acids Res 46, D624-D632.  Thank you!