$VAR1 = undef;

Summary for peptidase T01.010: proteasome subunit beta1c

Names
MEROPS Name	proteasome subunit beta1c
Other names	constitutive proteasome catalytic subunit 1, peptidylglutamyl-peptide hydrolysing proteasome subunit, proteasome subunit beta 1, proteasome subunit beta 1c, proteasome subunit beta 6, PRE3 g.p. (Saccharomyces cerevisiae), proteasome subunit Y (Homo sapiens), proteasome subunit delta (Homo sapiens), PSMB6 g.p. (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan PB >> Subclan PB(T) >> Family T1 >> Subfamily A >> T01.010
Holotype	proteasome subunit beta1c (Saccharomyces cerevisiae), Uniprot accession P38624 (peptidase unit: 20-215), MERNUM MER0001645
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Threonine
Peplist	Included in the Peplist with identifier PL00418
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.25 (Threonine-type endopeptidases) >> Peptidase 3.4.25.1
Enzymology	BRENDA database
Activity status	human: active (Seemuller et al., 2004) mouse: active (by similarity to other mammals)
Physiology	One of the peptidase units of the 20 S proteasome, and thus contributing to the major role of the proteasome in intracellular protein degradation.
Pharmaceutical relevance	Proteasome inhibitors exhibit anti-inflammatory and antiproliferative effects, and it is threrefore considered that inhibitors have the potential to be drugs for conditions such as cancer, rheumatoid arthritis and psoriasis that are characterised by these processes (Delcros et al., 2003; Elliott et al., 2003).
Pathways	KEGG	Proteasome
Other databases	TREEFAM	http://www.treefam.org/family/TF106221
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/p/-/ED-/-/-/- (based on 43 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	6	3	0	0	1	1	4	2
Pro	1	11	1	0	1	5	2	1
Ala	4	1	7	0	6	1	1	4
Val	0	8	4	0	4	4	1	2
Leu	5	6	9	2	1	4	1	4
Ile	1	3	0	0	1	0	0	2
Met	0	2	3	0	2	1	0	1
Phe	3	0	2	0	1	1	4	1
Tyr	4	0	2	2	0	3	3	0
Trp	1	1	1	0	0	0	0	0
Ser	4	3	1	0	5	1	4	4
Thr	1	0	3	0	1	2	4	0
Cys	1	0	0	0	0	0	0	0
Asn	3	2	4	0	0	2	0	1
Gln	0	0	1	0	2	2	1	2
Asp	0	1	1	19	3	0	0	1
Glu	1	0	2	20	1	2	4	4
Lys	2	0	0	0	1	0	2	1
Arg	4	1	2	0	2	2	2	1
His	0	1	0	0	2	2	0	2