$VAR1 = undef;

Summary for peptidase M10.057: mirabilysin

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

 

Names
MEROPS Namemirabilysin
Other namesZapA g.p. (Proteus mirabilis)
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily B >> M10.057
Holotypemirabilysin (Proteus mirabilis), Uniprot accession Q11137 (peptidase unit: 59-237), MERNUM MER0001613
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (28 cleavages)
PhysiologyDegrades host immunoglobulins, contributing to immune evasion.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bond-/-/-/- (based on 32 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 2 2 1 2 2 2 2 2
Pro 2 1 1 1 1 3 1 1
Ala 1 3 1 1 0 1 2 1
Val 1 1 1 2 2 2 1 1
Leu 3 2 2 2 3 2 1 2
Ile 3 3 3 3 3 2 3 4
Met 0 0 0 0 0 0 0 0
Phe 4 3 1 4 4 3 4 3
Tyr 2 1 1 1 0 0 1 1
Trp 0 0 0 0 0 0 0 0
Ser 1 1 1 1 5 1 0 1
Thr 2 1 1 0 1 2 1 2
Cys 0 2 3 2 2 1 1 0
Asn 0 1 1 1 1 0 1 1
Gln 1 1 2 2 1 1 1 1
Asp 1 0 2 1 2 1 2 1
Glu 1 0 1 2 0 1 1 0
Lys 3 4 5 2 3 5 5 4
Arg 2 5 4 5 2 4 4 6
His 0 0 0 0 0 0 0 0