$VAR1 = undef;

Summary for peptidase S01.237: neurotrypsin

Names
MEROPS Name	neurotrypsin
Other names	brain-specific serine protease BSSP-3, leydin, motopsin, PRSS12 g.p. (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.237
Holotype	neurotrypsin (Mus musculus), Uniprot accession O08762 (peptidase unit: 517-761), MERNUM MER0003457
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Serine
NC-IUBMB	Not yet included in IUBMB recommendations.
Activity status	human: putative mouse: active (by similarity to human)
Physiology	Neurotrypsin-mediated proteolysis may be required for normal synaptic function (Molinari et al., 2002).
Knockout	A four-base pair deletion in the gene has been found to be associated with autosomal recessive nonsyndromic mental retardation (Molinari et al., 2002).
Other databases	TREEFAM	http://www.treefam.org/family/TF329295