$VAR1 = undef;

Summary for peptidase S08.076: PCSK5 peptidase

Names
MEROPS Name	PCSK5 peptidase
Other names	PC5, PC5A, PC5B, PC5/6 [obs.], PC6A [obs.], PC6B [obs.], PCSK5, proprotein convertase 5, proprotein convertase 6 [obs.], proprotein convertase subtilisin/kexin type 5

Domain architecture

MEROPS Classification
Classification	Clan SB >> Subclan (none) >> Family S8 >> Subfamily B >> S08.076
Holotype	PCSK5 peptidase (Rattus norvegicus), Uniprot accession P41413 (peptidase unit: 150-441), MERNUM MER0001514
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00363
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (7 cleavages)
Activity status	human: active (Seidah & Chretien, 2004) mouse: active (by similarity to human)
Physiology	Processes various preproteins by cleavage at paired basic amino acids.
Knockout	Disruption of the proprotin convertase 5 gene in mouse shows that it is essential (Essalmani et al., 2006).
Other databases	PANTHER	http://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR42884:SF7
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	R/-/KR/Rs/val/-/- (based on 129 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	1	6	1	0	7	5	15	11
Pro	1	1	8	0	2	6	4	12
Ala	0	8	3	0	9	24	5	10
Val	4	4	1	0	3	25	2	7
Leu	0	6	1	0	2	22	10	13
Ile	6	3	0	0	1	9	6	1
Met	0	3	0	0	1	0	0	3
Phe	1	5	0	0	9	3	2	2
Tyr	2	0	0	0	7	0	1	1
Trp	0	0	0	0	0	1	0	0
Ser	0	16	4	0	37	5	15	9
Thr	0	8	3	0	3	12	6	9
Cys	0	0	0	0	3	0	0	1
Asn	0	5	0	0	2	0	5	4
Gln	1	10	0	0	7	0	6	4
Asp	0	2	0	0	11	5	15	8
Glu	3	5	2	0	11	1	13	15
Lys	8	23	59	4	1	8	8	5
Arg	97	13	41	125	2	0	4	4
His	3	6	1	0	8	0	3	3

Human genetics
Gene symbol	Locus	Megabases	Ensembl	Entrez gene	Gene Cards	OMIM
PCSK5	9		ENSG00000099139	5125	PCSK5	600488