| Activity |
|---|
| Catalytic type | Threonine |
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.25 (Threonine-type endopeptidases) >> Peptidase 3.4.25.1
|
| Enzymology | BRENDA database |
| Activity status | human: active (Seemuller et al., 2004)
mouse: active (Groettrup et al., 1995)
|
| Physiology | One of the peptidase units of the 20 S proteasome that is preferentially expressed upon stimulation of the immune system, and then partially replaces subunit 1 in the multipeptidase complex. May be particularly effective in the generation of antigenic peptides for the MHC class II system. |
| Knockout | A rat T-cell lymphoma (SP3) has been described that displays a defect in MHC class I-restricted presentation of influenza virus antigens that is attributable to under-expression of this proteasome subunit (Sibille et al., 1995). |
| Pharmaceutical relevance | Proteasome inhibitors exhibit anti-inflammatory and antiproliferative effects, and it is threrefore considered that inhibitors have the potential to be drugs for conditions such as cancer, rhuematoid arthritis and psoriasis that are characterised by these processes (Delcros et al., 2003; Elliott et al., 2003). |
| Pathways |
KEGG | Proteasome |
|
Other databases
| TREEFAM | http://www.treefam.org/family/TF106221 |
