$VAR1 = undef;

Summary for peptidase S01.079: transmembrane peptidase, serine 3

Names
MEROPS Name	transmembrane peptidase, serine 3
Other names	TADG-12 protease (Homo sapiens), TMPRSS3 g.p. (Homo sapiens), ECHOS1 protein, tumor associated differentially-expressed gene-12, transmembrane protease, serine 3

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.079
Holotype	transmembrane peptidase, serine 3 (Homo sapiens), Uniprot accession P57727 (peptidase unit: 217-451), MERNUM MER0005926
History	Identifier created: MEROPS 5.4 (23 March 2001)

Activity
Catalytic type	Serine
NC-IUBMB	Not yet included in IUBMB recommendations.
Activity status	human: active (Lee et al., 2003) mouse: active (Guipponi et al., 2002)
Physiology	Genetic abnormality (insertion of beta-satellite repeats) has been found to cause both congenital and childhood onset non-syndromic autosomal recessive deafness (Scott et al., 2001; Guipponi et al., 2002).
Other databases	TREEFAM	http://www.treefam.org/family/TF351678