$VAR1 = undef;

Summary for peptidase M10.029: matrix metallopeptidase-26

Names
MEROPS Name	matrix metallopeptidase-26
Other names	endometase, matrilysin-2, matrix metalloproteinase 26, MMP-26

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.029
Holotype	matrix metallopeptidase-26 (Homo sapiens), Uniprot accession Q9NRE1 (peptidase unit: 88-261), MERNUM MER0012072
History	Identifier created: MEROPS 5.2 (31 August 2000)

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00169
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (12 cleavages)
Activity status	human: active (Sang, 2004) mouse: active (by similarity to human) (Park et al., 2002)
Other databases	TREEFAM	http://www.treefam.org/family/TF315428
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/pa/l/alm/-/a/r (based on 17 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	2	0	0	4	0	0	0	1
Pro	0	8	1	1	0	0	0	2
Ala	0	3	0	5	0	0	6	1
Val	0	0	1	0	2	1	0	0
Leu	0	2	7	1	6	1	0	0
Ile	0	0	1	0	1	1	1	2
Met	0	1	1	0	3	0	0	0
Phe	0	0	0	1	0	1	0	0
Tyr	0	0	0	0	1	0	0	0
Trp	0	0	0	0	0	2	0	0
Ser	3	0	0	0	0	2	1	2
Thr	1	1	0	0	1	1	3	1
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	1	0	0	1	0
Gln	2	0	0	1	1	1	1	1
Asp	0	1	0	0	0	1	1	0
Glu	1	0	2	1	0	1	1	0
Lys	2	1	2	1	0	0	0	0
Arg	0	0	0	0	0	2	0	5
His	1	0	1	1	0	1	2	0

Human genetics
Gene symbol	Locus	Megabases	Ensembl	Entrez gene	Gene Cards	OMIM
MMP26	11p15		ENSG00000167346	56547	MMP26	605470