$VAR1 = undef;
Summary for peptidase S01.215: coagulation factor VIIa
| Names | |
|---|---|
| MEROPS Name | coagulation factor VIIa |
| Other names | F7 g.p. (Homo sapiens) (activated), FVIIa, Aryoseven, NovoSeven |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.215 |
| Holotype | coagulation factor VIIa (Homo sapiens), Uniprot accession P08709 (peptidase unit: 213-454), MERNUM MER0000215 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Serine | ||
| Peplist | Included in the Peplist with identifier PL00309 | ||
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.21 | ||
| Enzymology | BRENDA database | ||
| Proteolytic events | CutDB database (9 cleavages) | ||
| Activity status | human: active (Morrissey, 2004) mouse: active (Rosen et al., 1997) | ||
| Physiology | Proteolytically activates coagulation factors IX and X. | ||
| Knockout | The effects of the human inherited factor VII deficiency have been reviewed by Tuddenhamet al. (1995). Mice lacking factor VII develop normally but suffer fatal perinatal bleeding (Rosen et al., 1997). | ||
| Pharmaceutical relevance | Factor VIIa initiates the extrinsic coagulation cascade, and its central role in hemostasis and thrombosis makes it a key target of pharmaceutical research (Sichler et al., 2002). In liver transplantation, recombinant factor VIIa seemed to enhance thrombin generation without causing systemic coagulation (Meijer et al., 2003). | ||
| Pathways | KEGG | Complement and coagulation cascades | |
| Other databases | WIKIPEDIA | http://en.wikipedia.org/wiki/Coagulation_factor_VIIa | |
| Human genetics | ||||||
|---|---|---|---|---|---|---|
| Gene symbol | Locus | Megabases | Ensembl | Entrez gene | Gene Cards | OMIM |
| F7 | 13q34 | ENSG00000057593 | 2155 | F7 | 227500 | |
