Summary for peptidase S01.215: coagulation factor VIIa

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma


MEROPS Namecoagulation factor VIIa
Other namesF7 g.p. (Homo sapiens) (activated), FVIIa, Aryoseven, NovoSeven
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.215
Holotypecoagulation factor VIIa (Homo sapiens), Uniprot accession P08709 (peptidase unit: 213-454), MERNUM MER0000215
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00309
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase
EnzymologyBRENDA database
Proteolytic eventsCutDB database (9 cleavages)
Activity statushuman: active (Morrissey, 2004)
mouse: active (Rosen et al., 1997)
PhysiologyProteolytically activates coagulation factors IX and X.
KnockoutThe effects of the human inherited factor VII deficiency have been reviewed by Tuddenhamet al. (1995). Mice lacking factor VII develop normally but suffer fatal perinatal bleeding (Rosen et al., 1997).
Pharmaceutical relevanceFactor VIIa initiates the extrinsic coagulation cascade, and its central role in hemostasis and thrombosis makes it a key target of pharmaceutical research (Sichler et al., 2002). In liver transplantation, recombinant factor VIIa seemed to enhance thrombin generation without causing systemic coagulation (Meijer et al., 2003).
Pathways KEGGComplement and coagulation cascades
Other databases WIKIPEDIA
Relevant inhibitors MUGB
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
F7 13q34 ENSG00000057593 2155 F7 227500