$VAR1 = undef;

Summary for peptidase M10.017: membrane-type matrix metallopeptidase-4

Names
MEROPS Name	membrane-type matrix metallopeptidase-4
Other names	matrix metalloproteinase 17, membrane-type matrix metalloproteinase 4, MMP-17, matrix metalloproteinase, membrane-type 4, Mmp25beta (Brachydanio rerio), MT4-MMP, MTMMP-4

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.017
Holotype	membrane-type matrix metallopeptidase-4 (Homo sapiens), Uniprot accession Q9ULZ9 (peptidase unit: 125-319), MERNUM MER0002595
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Metallo
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (8 cleavages)
Activity status	human: active (Wang et al., 1999) mouse: active (English et al. (2000))
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/MMP17
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/p/-/-l/-/-/- (based on 27 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	1	0	1	3	2	0	0	3
Pro	2	10	0	1	0	1	0	2
Ala	0	3	3	3	2	2	3	2
Val	3	2	2	0	0	3	1	1
Leu	3	2	5	0	8	0	6	1
Ile	0	0	0	0	0	0	0	1
Met	1	1	1	0	0	0	0	0
Phe	0	1	0	0	2	1	1	1
Tyr	0	0	0	1	0	3	1	4
Trp	0	0	0	0	0	1	0	0
Ser	4	4	0	2	2	0	1	2
Thr	0	0	0	2	0	1	5	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	2	2	3	0	0	0
Gln	0	1	4	2	4	3	1	2
Asp	3	0	1	0	0	0	0	0
Glu	2	2	1	3	0	0	1	1
Lys	1	0	2	3	1	3	1	0
Arg	1	0	3	2	1	6	3	5
His	2	1	1	3	0	1	2	0