$VAR1 = undef;

Summary for peptidase C01.040: cathepsin H

Names
MEROPS Name	cathepsin H
Other names	benzoylarginine-naphthylamide (BANA) hydrolase, cathepsin B3, CTSH g.p. (Homo sapiens), lysosomal arginyl aminopeptidase

Domain architecture

MEROPS Classification
Classification	Clan CA >> Subclan (none) >> Family C1 >> Subfamily A >> C01.040
Holotype	cathepsin H (Homo sapiens), Uniprot accession P09668 (peptidase unit: 115-334), MERNUM MER0000629
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Cysteine
Peplist	Included in the Peplist with identifier PL00064
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.16
Enzymology	BRENDA database
Proteolytic events	CutDB database (10 cleavages)
Activity status	human: active (Kirschke, 2004) mouse: active (by similarity to rat) (Kirschke et al., 1977)
Physiology	Contributes to lysosomal proteolysis, and antigen processing. Suggested to be involved in the processing of pulmonary surfactant proteins B and C, and lamellar body genesis (Guttentag et al., 2003). May contribute to the transformation of LDL to an atherogenic moiety (Han et al., 2003).
Pathways	KEGG	Lysosome
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Cathepsin_H
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/--/-/-/- (based on 48 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	3	2	3	5	2	2	2	3
Pro	2	2	4	3	1	9	2	3
Ala	2	1	1	3	3	0	1	2
Val	3	3	6	3	2	2	4	3
Leu	2	3	3	4	2	2	1	2
Ile	0	1	2	3	5	2	3	3
Met	1	1	1	2	1	2	2	0
Phe	2	4	3	3	2	1	3	2
Tyr	1	0	0	1	1	0	0	0
Trp	0	1	0	0	1	0	0	0
Ser	3	0	3	6	8	3	5	1
Thr	1	1	2	1	4	5	1	1
Cys	0	2	0	0	0	0	0	0
Asn	3	2	0	1	2	2	1	1
Gln	5	3	3	1	1	1	3	2
Asp	0	0	0	0	1	1	1	2
Glu	0	4	3	1	1	4	1	1
Lys	2	2	1	4	3	1	2	2
Arg	1	0	0	6	2	1	1	3
His	0	0	0	1	0	0	1	0