Statistics for the MEROPS Database

Counts are for peptidases and their homologues, and sequences of the same, that are included in MEROPS.

Contents

  1. Totals for all catalytic types
  2. Aspartic peptidases
  3. Cysteine peptidases
  4. Glutamic peptidases
  5. Metallopeptidases
  6. Asparagine peptidases
  7. Serine peptidases
  8. Threonine peptidases
  9. Peptidases of unknown catalytic type
  10. Unclassifiable peptidases

TOTALS FOR ALL CATALYTIC TYPES
Catalytic Type Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
Aspartic 44974 319 32 65
Cysteine 178410 1001 80 232
Glutamic 396 7 2 3
Metallo 298031 1075 135 289
Asparagine 3881 24 3 22
Mixed 7212 53 0 9
Serine 334149 1703 121 346
Threonine 35113 103 8 48
Unknown 10120 20 0 8
Unclassifiable 4 3 24 -
Grand Total 912290 4308 405 1022
Total Families 268
Total clans 62
Aspartic Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
AA A1 pepsin A 16496 183 22 36
AA A2 HIV-1 retropepsin 1716 51 3 15
AA A3 cauliflower mosaic virus-type peptidase 61 6 0 -
AA A9 spumapepsin 58 1 0 1
AA A11 Copia transposon peptidase 3749 6 0 -
AA A28 DNA-damage inducible protein 1 3002 13 0 3
AA A32 PerP peptidase (Caulobacter sp.) 630 2 0 1
AC A8 signal peptidase II 6504 1 1 1
AD A22 presenilin 1 3694 31 0 3
AD A24 type 4 prepilin peptidase 1 6163 8 1 1
AE A25 gpr peptidase 323 1 1 1
AE A31 HybD peptidase 2046 8 1 1
AF A26 omptin 143 5 2 2
unassigned A5 thermopsin 102 1 1 -
unassigned A36 sporulation factor SpoIIGA 228 1 0 -
unassigned A37 sso1175 g.p. (Sulfolobus solfataricus) 59 1 0 -
Cysteine Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
CA C1 papain 15702 227 26 42
CA C2 calpain-2 6564 38 3 6
CA C6 family S30 unassigned peptidases 216 2 1 1
CA C10 streptopain 230 4 1 2
CA C12 ubiquitinyl hydrolase-L1 3118 21 1 4
CA C16 murine hepatitis coronavirus papain-like peptidase 1 73 10 0 3
CA C19 ubiquitin-specific peptidase 14 25714 180 1 21
CA C28 foot-and-mouth disease virus L-peptidase 29 2 1 1
CA C31 family S32 unassigned peptidases 19 1 0 1
CA C32 porcine reproductive and respiratory syndrome virus nsp4 peptidase 29 3 0 1
CA C33 equine arteritis virus Nsp2-type cysteine peptidase 14 1 0 1
CA C39 bacteriocin-processing peptidase 3682 8 0 1
CA C47 staphopain A 28 4 1 2
CA C51 D-alanyl-glycyl peptidase (staphylococcal phage phi11-type) 214 3 0 1
CA C54 autophagin-1 1822 18 0 2
CA C58 YopT peptidase 51 6 0 2
CA C64 Cezanne peptidase 1339 6 0 4
CA C65 otubain-1 1226 4 0 3
CA C66 IdeS peptidase 60 3 0 1
CA C67 CylD peptidase 538 4 0 2
CA C70 AvrRpt2 peptidase 9 1 0 -
CA C71 pseudomurein endoisopeptidase Pei 2 1 0 -
CA C76 viral tegument protein deubiquitinylating peptidase 40 1 0 1
CA C78 UfSP1 peptidase 925 6 0 2
CA C83 gamma-glutamylcysteine dipeptidyltranspeptidase 633 5 0 1
CA C85 OTLD1 deubiquitinylating enzyme 3637 17 0 5
CA C86 ataxin-3 1276 10 0 2
CA C87 nairovirus deubiquitinylating peptidase 15 1 0 1
CA C93 LapG peptidase (Pseudomonas fluorescens) 297 1 0 1
CA C96 McjB peptidase 171 1 0 -
CA C98 USPL1 peptidase 209 1 0 -
CA C100 agglutinin peptidase (Marasmius oreades) 6 1 0 3
CA C101 OTULIN peptidase 358 1 0 1
CA C102 GtgE peptidase 1 1 0 1
CA C104 PlyC phage lysin 27 1 0 1
CA C105 family S32 unassigned peptidases 1 1 0 -
CA C110 kyphoscoliosis peptidase 1342 1 0 -
CA C111 coagulation factor XIIIa 2856 2 0 1
CA C113 IgdE peptidase (Streptococcus suis) 90 1 0 -
CA C115 MINDY-1 protein 1233 2 0 -
CA C117 SpvD g.p. (Salmonella enterica) 8 1 0 1
CD C11 clostripain 465 4 1 1
CD C13 legumain (plant beta form) 2152 13 1 2
CD C14 caspase-1 6217 59 11 15
CD C25 gingipain RgpA 469 4 2 3
CD C50 separase (yeast-type) 895 7 1 1
CD C80 RTX self-cleaving toxin 101 3 0 2
CD C84 prtH peptidase (Tannerella forsythensis ATCC 43037) 13 1 0 -
CE C5 adenain 92 1 1 1
CE C48 Ulp1 peptidase 6004 58 1 5
CE C55 YopJ protein 90 8 0 -
CE C57 vaccinia virus I7L processing peptidase 34 1 0 -
CE C63 African swine fever virus processing peptidase 1 1 0 -
CE C79 ElaD peptidase (Escherichia-type) 90 1 0 -
CF C15 pyroglutamyl-peptidase I (prokaryote) 2524 9 1 1
CL C60 sortase A (Staphylococcus-type) 1956 9 2 5
CL C82 L,D-transpeptidase (Enterococcus-type) 9809 8 0 2
CM C18 hepacivirin 197 2 0 1
CN C9 sindbis virus-type nsP2 peptidase 43 2 0 2
CO C40 dipeptidyl-peptidase VI (bacteria) 13452 20 0 3
CP C97 DeSI-1 peptidase 2447 14 0 1
CQ C53 pestivirus Npro peptidase 49 2 0 2
CR C108 Prp peptidase (Staphylococcus aureus) 833 2 0 2
unassigned C7 chestnut blight fungus virus p29 peptidase 7 1 0 -
unassigned C8 chestnut blight fungus virus p48 peptidase 6 1 0 -
unassigned C21 tymovirus peptidase 33 1 0 1
unassigned C23 carlavirus peptidase 44 1 0 -
unassigned C27 rubella virus peptidase 1 1 0 -
unassigned C36 beet necrotic yellow vein furovirus-type papain-like peptidase 3 1 0 -
unassigned C42 beet yellows virus-type papain-like peptidase 10 4 0 -
unassigned C49 Strawberry mottle virus peptidase 4 1 0 -
unassigned C75 AgrB peptidase 119 2 0 -
unassigned C116 dermonecrotic toxin (Pasteurella multocida) 2 1 0 1
unassigned C118 EspL g.p. (Escherichia coli) 259 1 0 -
PA C3 poliovirus-type picornain 3C 679 19 2 11
PA C4 potyvirus P1 peptidase 217 14 1 1
PA C24 rabbit hemorrhagic disease virus 3C-like peptidase 26 3 0 1
PA C30 porcine transmissible gastroenteritis virus-type main peptidase 97 6 1 5
PA C37 calicivirin 37 2 1 2
PA C62 gill-associated virus 3C-like peptidase 2 1 0 -
PA C74 pestivirus Npro peptidase 26 1 0 2
PA C99 iflavirus processing peptidase 3 1 0 -
PA C107 alphamesonivirus 3C-like peptidase 8 1 0 -
PB C44 amidophosphoribosyltransferase precursor 11365 16 3 7
PB C45 acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase precursor 1106 2 0 1
PB C59 penicillin V acylase precursor 2011 2 1 2
PB C69 dipeptidase A 2376 6 0 -
PB C89 acid ceramidase precursor 710 4 0 -
PB C95 lysosomal 66.3 kDa protein (Mus musculus-type) 786 2 0 2
PC C26 gamma-glutamyl hydrolase 21637 43 13 13
PC C56 PfpI peptidase 13898 17 2 8
PD C46 hedgehog protein 1201 15 0 4
Glutamic Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
GA G1 scytalidoglutamic peptidase 268 6 2 2
GB G2 pre-neck appendage protein (Bacillus phage phi29) 128 1 0 1
Metallo Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
MA M1 aminopeptidase N 14718 64 9 12
MA M2 angiotensin-converting enzyme peptidase unit 2 1429 9 2 4
MA M3 thimet oligopeptidase 10584 17 6 8
MA M4 thermolysin 2480 23 6 5
MA M5 mycolysin 22 1 1 -
MA M6 immune inhibitor A peptidase (Bacillus sp.) 1148 3 0 1
MA M7 snapalysin 109 1 0 1
MA M8 leishmanolysin 1724 11 1 1
MA M9 bacterial collagenase V 262 4 1 1
MA M10 matrix metallopeptidase-1 7661 66 12 21
MA M11 gametolysin 149 3 1 -
MA M12 astacin 17919 235 31 34
MA M13 neprilysin 8080 48 2 4
MA M26 IgA1-specific metallopeptidase 289 4 1 -
MA M27 tentoxilysin 44 3 2 3
MA M30 hyicolysin 144 1 0 -
MA M32 carboxypeptidase Taq 1791 6 1 4
MA M34 anthrax lethal factor 72 2 1 2
MA M35 deuterolysin 265 5 2 3
MA M36 fungalysin 775 1 0 1
MA M41 FtsH peptidase 11574 36 0 7
MA M43 cytophagalysin 1801 6 1 1
MA M48 Ste24 peptidase 12563 23 1 4
MA M49 dipeptidyl-peptidase III 1083 10 1 2
MA M54 archaelysin 781 3 0 1
MA M56 BlaR1 peptidase 2747 3 0 2
MA M57 prtB g.p. (Myxococcus xanthus) 58 1 0 -
MA M60 enhancin 166 6 0 1
MA M61 glycyl aminopeptidase 3401 2 0 -
MA M64 IgA peptidase (Clostridium ramosum-type) 106 1 0 1
MA M66 StcE peptidase 186 1 0 1
MA M72 peptidyl-Asp metallopeptidase 113 1 1 -
MA M76 Atp23 peptidase (animal-type) 874 5 0 -
MA M78 ImmA peptidase 2061 2 0 1
MA M80 Wss1 peptidase (Saccharomyces-type) 345 5 0 -
MA M84 MpriBi peptidase (Bacillus sp.) 29 1 0 -
MA M85 NleC peptidase (Escherichia coli) 12 1 0 1
MA M88 IMPa peptidase (Pseudomonas aeruginosa) 31 1 0 1
MA M90 MtfA peptidase 1058 1 0 1
MA M91 NleD peptidase (Escherichia coli-type) 10 1 0 -
MA M93 BACCAC_01431 g.p. (Bacteroides caccae) and similar 233 1 0 -
MA M95 selecase (Methanocaldococcus jannaschii) 4 1 0 1
MA M97 EcxAB peptidase 170 1 0 1
MA M98 YghJ g.p. (Escherichia coli) 431 3 0 -
MA M100 spartan peptidase 31 1 0 -
MA M101 flagellinolysin 98 1 0 -
MA M102 DA1 peptidase (Arabidopsis thaliana) 822 1 0 -
MC M14 carboxypeptidase A1 12658 75 11 12
MC M86 PghP gamma-polyglutamate hydrolase (bacteriophage) 154 1 0 1
MC M99 Csd4 peptidase (Helicobacter pylori) 1 1 0 1
MD M15 zinc D-Ala-D-Ala carboxypeptidase (Streptomyces-type) 5883 13 3 6
MD M74 murein endopeptidase 377 1 0 1
ME M16 pitrilysin 20108 58 4 18
ME M44 pox virus metallopeptidase 41 1 0 -
MF M17 leucine aminopeptidase 3 5746 21 3 6
MG M24 methionyl aminopeptidase 1 (Escherichia-type) 14583 37 3 20
MH M18 aminopeptidase I 3103 6 2 4
MH M20 glutamate carboxypeptidase 39813 47 11 20
MH M28 aminopeptidase S (Streptomyces-type) 7107 46 4 13
MH M42 glutamyl aminopeptidase (bacterium) 4133 12 0 8
MJ M19 membrane dipeptidase 4697 13 1 6
MJ M38 isoaspartyl dipeptidase (metallo-type) 24227 15 6 12
MM M50 site 2 peptidase 9905 20 1 2
MN M55 D-aminopeptidase DppA 759 2 0 1
MO M23 beta-lytic metallopeptidase 10461 18 2 9
MP M67 RPN11 peptidase 7438 30 0 12
MQ M29 aminopeptidase T 2616 4 0 2
MS M75 imelysin 329 1 0 1
MT M81 microcystinase MlrC 559 1 0 1
unassigned M73 camelysin 193 2 0 -
unassigned M77 tryptophanyl aminopeptidase 7-DMATS-type peptidase 197 4 1 1
unassigned M79 RCE1 peptidase (Saccharomyces cerevisiae-type) 9336 11 0 1
unassigned M82 PrsW peptidase 1375 1 0 -
unassigned M87 chloride channel accessory protein 1 711 6 0 -
unassigned M96 Tiki1 peptidase 1068 2 0 -
Asparagine Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
NA N1 nodavirus peptide lyase 8 1 1 2
NA N2 tetravirus coat protein 7 1 0 2
NA N8 poliovirus-type picornain 3C 868 1 0 2
NB N6 YscU protein 1890 5 0 3
NC N7 reovirus type 1 coat protein 22 2 0 1
ND N4 Tsh peptidase 456 2 0 3
NE N5 picobirnavirus self-cleaving protein 6 1 0 1
PD N9 intein-containing V-type proton ATPase catalytic subunit A 89 1 1 1
PD N10 intein-containing replicative DNA helicase precursor 461 9 1 7
PD N11 peptidase Clp (type 7) 74 1 0 -
Mixed Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
PB P2 EGF-like module containing mucin-like hormone receptor-like 2 6518 48 0 4
PE P1 DmpA aminopeptidase 694 5 0 5
Serine Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
PA S1 chymotrypsin A (cattle-type) 57852 694 52 131
PA S3 togavirin 62 1 1 1
PA S6 IgA1-specific serine peptidase (Neisseria-type) 297 11 1 4
PA S7 flavivirin 124 2 1 3
PA S29 hepacivirin 213 2 1 2
PA S30 potyvirus P1 peptidase 77 2 0 -
PA S31 pestivirus NS3 polyprotein peptidase 32 1 0 1
PA S32 equine arteritis virus serine peptidase 31 2 0 2
PA S39 sobemovirus peptidase 66 2 0 1
PA S46 dipeptidyl-peptidase 7 (Porphyromonas gingivalis-type) 1052 3 0 2
PA S55 SpoIVB peptidase 339 1 1 -
PA S64 Ssy5 peptidase 40 1 0 -
PA S65 picornain-like serine peptidase (Breda-1 torovirus) 2 1 0 -
PA S75 White bream virus serine peptidase 1 1 0 -
PB S45 penicillin G acylase precursor 2586 5 1 4
PC S51 dipeptidase E 2560 3 2 3
SB S8 subtilisin Carlsberg 28702 209 13 38
SB S53 sedolisin 2644 13 5 4
SC S9 prolyl oligopeptidase 47744 210 17 35
SC S10 carboxypeptidase Y 10335 87 3 7
SC S15 Xaa-Pro dipeptidyl-peptidase 6078 1 1 2
SC S28 lysosomal Pro-Xaa carboxypeptidase 3659 31 2 2
SC S33 prolyl aminopeptidase 28544 150 9 22
SC S37 PS-10 peptidase 49 1 0 -
SC S82 autocrine proliferation repressor protein A (Dictyostelium discoideum) 486 1 0 -
SE S11 D-Ala-D-Ala carboxypeptidase A 12907 11 1 6
SE S12 D-Ala-D-Ala carboxypeptidase B 24279 32 2 9
SE S13 D-Ala-D-Ala peptidase C 2931 6 1 2
SF S24 repressor LexA 9966 6 1 3
SF S26 signal peptidase I 14920 34 1 3
SH S21 cytomegalovirus assemblin 73 6 1 5
SH S73 gpO peptidase (Enterobacteria phage P2) 338 1 0 -
SH S77 prohead peptidase gp21 (bacteriophage T4) 34 1 0 1
SH S78 prohead peptidase (bacteriophage HK97) 1517 2 0 -
SH S80 prohead peptidase gp175 (Pseudomonas aeruginosa phage phiKZ) 6 1 0 -
SJ S16 Lon-A peptidase 17814 25 1 7
SJ S50 infectious pancreatic necrosis birnavirus Vp4 peptidase 25 4 0 2
SJ S69 Tellina virus 1 VP4 peptidase 1 1 0 1
SK S14 peptidase Clp (type 1) 12820 15 1 11
SK S41 C-terminal processing peptidase-1 11537 19 1 5
SK S49 signal peptide peptidase A 8713 9 0 3
SO S74 Escherichia coli phage K1F endosialidase CIMCD self-cleaving protein 71 2 0 2
SP S59 nucleoporin 145 1337 11 0 4
SR S60 lactoferrin 1142 11 0 5
SS S66 murein tetrapeptidase LD-carboxypeptidase (Pseudomonas-type) 3672 3 1 3
ST S54 rhomboid-1 (Diptera) 14157 52 0 3
unassigned S48 HetR putative peptidase 88 1 0 1
unassigned S62 influenza A PA peptidase 56 1 0 1
unassigned S68 PIDD auto-processing protein unit 1 181 2 0 -
unassigned S71 MUC1 self-cleaving mucin 698 2 0 1
unassigned S72 dystroglycan 372 2 0 1
unassigned S79 CARD8 self-cleaving protein 553 7 0 2
unassigned S81 destabilase 366 1 0 1
Threonine Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
PB T1 archaean proteasome, beta component 17975 60 2 36
PB T2 glycosylasparaginase precursor 4148 9 1 6
PB T3 gamma-glutamyltransferase 1 (bacterial-type) 8790 30 4 4
PB T7 CwpV (Clostridium difficile) self-cleaving threonine peptidase 5 1 0 -
PE T5 ornithine acetyltransferase precursor 3822 2 1 2
unassigned T8 HopB1 g.p. (Pseudomonas syringae) 373 1 0 -
Unknown Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
unassigned U32 collagenase (Porphyromonas-type) 2731 6 0 2
unassigned U40 protein P5 murein endopeptidase (bacteriophage phi-6) 2 1 0 -
unassigned U49 Lit peptidase 10 1 0 -
unassigned U56 homomultimeric peptidase 235 1 0 1
unassigned U57 yabG protein (Bacillus-type) 204 1 0 -
unassigned U62 microcin-processing peptidase 1 3344 4 0 3
unassigned U69 AIDA-I self-cleaving autotransporter protein (Escherichia coli) 662 2 0 2
unassigned U72 Dop isopeptidase 536 1 0 -
unassigned U73 small protease (Pseudomonas aeruginosa) 38 1 0 -
unassigned U74 neprosin 2236 1 0 -
unassigned U75 Ras/Rap1-specific peptidase 122 1 0 -
Unclassifiable Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
unassignable unassignable 4 3 24 -