Statistics for the MEROPS Database

Counts are for peptidases and their homologues, and sequences of the same, that are included in MEROPS.

Contents

  1. Totals for all catalytic types
  2. Aspartic peptidases
  3. Cysteine peptidases
  4. Glutamic peptidases
  5. Metallopeptidases
  6. Asparagine peptidases
  7. Serine peptidases
  8. Threonine peptidases
  9. Peptidases of unknown catalytic type
  10. Unclassifiable peptidases

TOTALS FOR ALL CATALYTIC TYPES
Catalytic Type Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
Aspartic 55609 323 49 72
Cysteine 195397 1056 180 279
Glutamic 11405 22 8 5
Metallo 395988 1083 209 348
Asparagine 3816 24 13 24
Mixed 6573 54 2 9
Serine 421390 1726 176 404
Threonine 39409 105 14 51
Unknown 6480 14 8 9
Unclassifiable 5 4 25 -
Grand Total 1136072 4411 684 1201
Total Families 277
Total clans 65
Aspartic Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
AA A1 20395 184 23 38
AA A2 HIV-1 retropepsin 1692 52 4 15
AA A3 cauliflower mosaic virus-type peptidase 76 6 1 -
AA A9 spumapepsin 53 1 1 1
AA A11 Copia transposon peptidase 3791 6 1 -
AA A28 DNA-damage inducible protein 1 2918 14 1 4
AA A32 PerP peptidase (Caulobacter sp.) 625 2 1 1
AC A8 signal peptidase II 8974 1 2 1
AD A22 presenilin 1 3642 31 1 3
AD A24 type 4 prepilin peptidase 1 8308 8 2 1
AE A25 gpr peptidase 1201 1 2 1
AE A31 HybD peptidase 2031 8 2 5
AF A26 omptin 449 5 3 2
unassigned A5 thermopsin 164 1 2 -
unassigned A36 sporulation factor SpoIIGA 1240 1 1 -
unassigned A37 sso1175 g.p. (Sulfolobus solfataricus) 50 1 1 -
unassigned A39 0 1 1 -
Cysteine Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
CA C1 papain 21351 232 27 44
CA C2 calpain-2 6272 39 4 7
CA C6 family S30 unassigned peptidases 410 2 2 1
CA C10 streptopain 1018 4 2 2
CA C12 ubiquitinyl hydrolase-L1 5229 21 2 5
CA C16 murine hepatitis coronavirus papain-like peptidase 1 98 11 1 3
CA C19 ubiquitin-specific peptidase 14 24487 201 2 25
CA C21 tymovirus peptidase 50 1 1 1
CA C28 foot-and-mouth disease virus L-peptidase 29 2 2 1
CA C31 family S32 unassigned peptidases 19 1 1 1
CA C32 porcine reproductive and respiratory syndrome virus nsp4 peptidase 29 3 1 1
CA C33 equine arteritis virus Nsp2-type cysteine peptidase 14 1 1 1
CA C39 bacteriocin-processing peptidase 3573 8 1 1
CA C47 staphopain A 27 4 2 2
CA C51 D-alanyl-glycyl peptidase (staphylococcal phage phi11-type) 205 3 1 1
CA C54 autophagin-1 1760 18 1 2
CA C58 YopT peptidase 50 6 1 2
CA C64 Cezanne peptidase 1313 6 1 5
CA C65 otubain-1 1170 4 1 3
CA C66 IdeS peptidase 60 3 1 1
CA C67 CylD peptidase 512 4 1 2
CA C70 AvrRpt2 peptidase 9 1 1 -
CA C71 pseudomurein endoisopeptidase Pei 2 1 1 -
CA C76 viral tegument protein deubiquitinylating peptidase 40 1 1 1
CA C78 UfSP1 peptidase 896 8 1 3
CA C83 gamma-glutamylcysteine dipeptidyltranspeptidase 601 5 1 1
CA C85 OTUD5 peptidase (Homo sapiens) 3515 18 1 5
CA C86 ataxin-3 1190 10 1 2
CA C87 nairovirus deubiquitinylating peptidase 15 1 1 1
CA C93 LapG peptidase (Pseudomonas fluorescens) 283 1 1 2
CA C96 McjB peptidase 166 1 1 -
CA C98 USPL1 peptidase 203 1 1 -
CA C100 agglutinin peptidase (Marasmius oreades) 6 1 1 3
CA C101 OTULIN peptidase 349 2 1 2
CA C102 GtgE peptidase 1 1 1 1
CA C103 1 1 1 -
CA C104 PlyC phage lysin 27 1 1 1
CA C105 family S32 unassigned peptidases 1 1 1 -
CA C110 kyphoscoliosis peptidase 1310 1 1 -
CA C111 coagulation factor XIIIa 2292 10 2 1
CA C113 IgdE peptidase (Streptococcus suis) 69 1 1 -
CA C115 MINDY-1 protein 1206 2 1 -
CA C117 SpvD g.p. (Salmonella enterica) 9 1 1 1
CA C119 LotA g.p. (Legionella pneumophila) 41 1 1 -
CA C121 MINDY-4 peptidase 1055 2 1 -
CD C11 clostripain 1257 7 2 5
CD C13 legumain (plant beta form) 3648 13 2 4
CD C14 caspase-1 9165 60 12 16
CD C25 gingipain RgpA 1393 4 3 3
CD C50 separase (yeast-type) 881 7 2 3
CD C80 RTX self-cleaving toxin 101 3 1 2
CD C84 prtH peptidase (Tannerella forsythensis ATCC 43037) 13 1 1 -
CD C123 0 1 1 -
CE C5 adenain 146 1 2 1
CE C48 Ulp1 peptidase 5777 58 2 10
CE C55 YopJ protein 90 8 1 1
CE C57 vaccinia virus I7L processing peptidase 34 1 1 -
CE C63 African swine fever virus processing peptidase 1 1 1 -
CE C79 ElaD peptidase (Escherichia-type) 57 1 1 1
CE C122 SdeA (Legionella pneumophila) 9 1 1 1
CF C15 pyroglutamyl-peptidase I (prokaryote) 2474 9 2 1
CL C60 sortase A (Staphylococcus-type) 1919 9 3 6
CL C82 L,D-transpeptidase (Enterococcus-type) 9593 8 1 4
CM C18 hepacivirin 434 2 1 1
CN C9 sindbis virus-type nsP2 peptidase 81 2 1 2
CO C40 dipeptidyl-peptidase VI (bacteria) 18287 21 1 5
CP C97 desumoylating isopeptidase 1 2367 14 1 1
CQ C53 pestivirus Npro peptidase 49 2 1 2
CR C108 Prp peptidase (Staphylococcus aureus) 833 2 1 2
unassigned C7 chestnut blight fungus virus p29 peptidase 12 1 1 -
unassigned C8 chestnut blight fungus virus p48 peptidase 7 1 1 -
unassigned C23 carlavirus peptidase 44 1 1 -
unassigned C27 rubella virus peptidase 1 1 1 -
unassigned C36 beet necrotic yellow vein furovirus-type papain-like peptidase 3 1 1 -
unassigned C42 beet yellows virus-type papain-like peptidase 10 4 1 -
unassigned C49 Strawberry mottle virus 3C-like peptidase 2 1 1 -
unassigned C75 AgrB peptidase 119 2 1 -
unassigned C106 archaeosortase A (Haloferax volcanii ) 118 1 1 -
unassigned C116 dermonecrotic toxin (Pasteurella multocida) 2 1 1 1
unassigned C118 EspL g.p. (Escherichia coli) 88 1 1 -
unassigned C120 mavirus processing peptidase 4 1 1 -
PA C3 poliovirus-type picornain 3C 1136 19 3 12
PA C4 potyvirus P1 peptidase 214 14 2 1
PA C24 rabbit hemorrhagic disease virus 3C-like peptidase 27 3 1 1
PA C30 porcine transmissible gastroenteritis virus-type main peptidase 97 7 2 7
PA C37 calicivirin 36 2 2 2
PA C62 gill-associated virus 3C-like peptidase 2 1 1 -
PA C74 pestivirus Npro peptidase 26 1 1 2
PA C99 iflavirus processing peptidase 3 1 1 -
PA C107 alphamesonivirus 3C-like peptidase 8 1 1 1
PB C44 amidophosphoribosyltransferase precursor 10994 16 4 7
PB C45 acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase precursor 1079 2 1 1
PB C59 penicillin V acylase precursor 1969 2 2 3
PB C69 dipeptidase A 2310 6 1 -
PB C89 acid ceramidase precursor 700 4 1 2
PB C95 lysosomal 66.3 kDa protein (Mus musculus-type) 755 2 1 2
PC C26 gamma-glutamyl hydrolase 21266 44 14 17
PC C56 PfpI peptidase 13620 17 3 10
PD C46 hedgehog protein 1173 15 1 4
Glutamic Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
GA G1 scytalidoglutamic peptidase 939 6 3 2
GB G2 pre-neck appendage protein (Bacillus phage phi29) 125 1 1 1
GC G4 1055 2 1 -
GC G6 Ras/Rap1-specific peptidase 100 1 1 1
unassigned G3 strawberry mottle virus glutamic peptidase 2 1 1 -
unassigned G5 RCE1 peptidase (Saccharomyces cerevisiae-type) 9184 11 1 1
Metallo Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
MA M1 aminopeptidase N 18192 65 10 15
MA M2 angiotensin-converting enzyme peptidase unit 2 1399 9 3 4
MA M3 thimet oligopeptidase 16871 17 7 8
MA M4 thermolysin 6405 23 7 5
MA M5 mycolysin 145 1 2 -
MA M6 immune inhibitor A peptidase (Bacillus sp.) 3527 3 1 1
MA M7 snapalysin 1251 1 1 1
MA M8 leishmanolysin 2571 12 2 1
MA M9 collagenase V (Clostridium histolyticum) 1755 5 2 3
MA M10 matrix metallopeptidase-1 13381 65 13 21
MA M11 gametolysin 248 3 2 -
MA M12 astacin 25527 241 32 32
MA M13 neprilysin 12561 48 3 4
MA M26 IgA1-specific metallopeptidase 2348 4 2 -
MA M27 tentoxilysin 73 4 3 4
MA M30 hyicolysin 485 1 1 -
MA M32 carboxypeptidase Taq 5274 6 2 4
MA M34 anthrax lethal factor 116 3 2 3
MA M35 deuterolysin 262 5 3 3
MA M36 fungalysin 765 1 1 1
MA M41 FtsH peptidase 11399 36 1 7
MA M43 cytophagalysin 1767 6 2 1
MA M48 Ste24 peptidase 12245 23 2 5
MA M49 dipeptidyl-peptidase III 1042 11 2 5
MA M54 archaelysin 767 3 1 1
MA M56 BlaR1 peptidase 2716 3 1 2
MA M57 prtB g.p. (Myxococcus xanthus) 58 1 1 -
MA M60 enhancin 164 6 1 1
MA M61 glycyl aminopeptidase 2987 2 1 1
MA M64 IgA peptidase (Clostridium ramosum-type) 106 1 1 1
MA M66 StcE peptidase 183 1 1 1
MA M72 peptidyl-Asp metallopeptidase 114 2 2 -
MA M76 Atp23 peptidase (animal-type) 831 5 1 -
MA M78 ImmA peptidase 1957 2 1 1
MA M80 Wss1 peptidase (Saccharomyces-type) 345 5 1 2
MA M84 MpriBi peptidase (Bacillus sp.) 29 1 1 -
MA M85 NleC peptidase (Escherichia coli) 12 1 1 1
MA M88 IMPa peptidase (Pseudomonas aeruginosa) 31 1 1 1
MA M90 MtfA peptidase 1033 1 1 1
MA M91 NleD peptidase (Escherichia coli-type) 10 1 1 -
MA M93 BACCAC_01431 g.p. (Bacteroides caccae) and similar 232 1 1 1
MA M95 abylysin (Pyrococcus abyssi) 35 3 1 3
MA M97 EcxAB peptidase 170 1 1 1
MA M98 YghJ g.p. (Escherichia coli) 413 4 1 -
MA M100 spartan peptidase 32 1 1 1
MA M101 flagellinolysin 89 1 1 -
MA M102 DA1 peptidase (Arabidopsis thaliana) 471 1 1 -
MC M14 carboxypeptidase A1 20035 76 12 18
MC M86 PghP gamma-polyglutamate hydrolase (bacteriophage) 154 1 1 1
MC M99 Csd4 peptidase (Helicobacter pylori) 1 1 1 1
MD M15 zinc D-Ala-D-Ala carboxypeptidase (Streptomyces-type) 10687 13 4 8
MD M74 murein endopeptidase 2298 1 1 1
ME M16 pitrilysin 28084 58 5 22
ME M44 pox virus metallopeptidase 41 1 1 -
MF M17 leucyl aminopeptidase 3 5685 21 4 9
MG M24 methionyl aminopeptidase 1 (Escherichia-type) 23669 38 4 24
MH M18 aminopeptidase I 8521 6 3 4
MH M20 glutamate carboxypeptidase 47228 47 12 25
MH M28 aminopeptidase S (Streptomyces-type) 19585 46 5 15
MH M42 glutamyl aminopeptidase (bacterium) 4058 12 1 9
MJ M19 membrane dipeptidase 9245 13 2 8
MJ M38 isoaspartyl dipeptidase (metallo-type) 22973 15 7 15
MM M50 site 2 peptidase 9454 20 2 2
MN M55 D-aminopeptidase DppA 742 2 1 1
MO M23 beta-lytic metallopeptidase 10733 18 3 10
MP M67 PSMD14 peptidase 7200 30 1 15
MQ M29 aminopeptidase T 6570 4 1 2
MS M75 imelysin 328 1 1 1
MT M81 microcystinase MlrC 558 1 1 1
MU M103 TldD peptidase (Escherichia coli) 3340 4 1 5
unassigned M73 camelysin 181 2 1 1
unassigned M77 tryptophanyl aminopeptidase 7-DMATS-type peptidase 194 4 2 3
unassigned M82 PrsW peptidase 1328 1 1 -
unassigned M87 chloride channel accessory protein 1 702 6 1 -
Asparagine Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
NA N1 nodavirus peptide lyase 8 1 2 2
NA N2 tetravirus coat protein 7 1 1 2
NA N8 poliovirus-type picornain 3C 822 1 1 3
NB N6 YscU protein 1881 5 1 4
NC N7 reovirus type 1 coat protein 22 2 1 1
ND N4 Tsh peptidase 448 2 1 3
NE N5 picobirnavirus self-cleaving protein 6 1 1 1
PD N9 intein-containing V-type proton ATPase catalytic subunit A 88 1 2 1
PD N10 intein-containing replicative DNA helicase precursor 460 9 2 7
PD N11 peptidase Clp (type 7) 74 1 1 -
Mixed Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
PB P2 EGF-like module containing mucin-like hormone receptor-like 2 5881 49 1 4
PE P1 DmpA aminopeptidase 692 5 1 5
Serine Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
PA S1 chymotrypsin A (cattle-type) 70904 702 53 141
PA S3 togavirin 85 1 2 1
PA S6 IgA1-specific serine peptidase (Neisseria-type) 1373 12 2 6
PA S7 flavivirin 360 2 2 3
PA S29 hepacivirin 236 2 2 2
PA S30 potyvirus P1 peptidase 97 2 1 -
PA S31 pestivirus NS3 polyprotein peptidase 32 1 1 1
PA S32 equine arteritis virus serine peptidase 121 2 1 2
PA S39 sobemovirus peptidase 72 2 1 2
PA S46 dipeptidyl-peptidase 7 (Porphyromonas gingivalis-type) 1028 4 1 2
PA S55 SpoIVB peptidase 338 1 2 -
PA S64 Ssy5 peptidase 40 1 1 -
PA S65 picornain-like serine peptidase (Breda-1 torovirus) 2 1 1 -
PA S75 White bream virus serine peptidase 1 1 1 -
PB S45 penicillin G acylase precursor 2556 5 2 4
PC S51 dipeptidase E 4376 3 3 3
SB S8 subtilisin Carlsberg 38213 210 15 46
SB S53 sedolisin 6026 13 6 4
SC S9 prolyl oligopeptidase 61054 213 18 49
SC S10 carboxypeptidase Y 10148 87 4 7
SC S15 Xaa-Pro dipeptidyl-peptidase 7477 1 2 3
SC S28 lysosomal Pro-Xaa carboxypeptidase 3590 31 3 2
SC S33 prolyl aminopeptidase 33234 151 10 24
SC S37 PS-10 peptidase 1190 1 1 -
SC S82 autocrine proliferation repressor protein A (Dictyostelium discoideum) 383 1 1 -
SE S11 D-Ala-D-Ala carboxypeptidase A 15878 12 2 9
SE S12 D-Ala-D-Ala carboxypeptidase B 29459 33 3 11
SE S13 D-Ala-D-Ala peptidase C 6481 6 2 3
SF S24 repressor LexA 14485 6 2 4
SF S26 signal peptidase I 19744 34 2 4
SH S21 cytomegalovirus assemblin 89 7 2 5
SH S73 gpO peptidase (Enterobacteria phage P2) 330 1 1 -
SH S77 prohead peptidase gp21 (bacteriophage T4) 116 1 1 1
SH S78 prohead peptidase (bacteriophage HK97) 1492 2 1 -
SH S80 prohead peptidase gp175 (Pseudomonas aeruginosa phage phiKZ) 7 2 1 -
SJ S16 Lon-A peptidase 21376 25 2 8
SJ S50 infectious pancreatic necrosis birnavirus Vp4 peptidase 24 4 1 2
SJ S69 Tellina virus 1 VP4 peptidase 1 1 1 1
SK S14 peptidase Clp (type 1) 17297 15 2 13
SK S41 C-terminal processing peptidase-1 14450 20 2 8
SK S49 signal peptide peptidase A (Pseudomonas aeruginosa) 15504 9 1 3
SO S74 Escherichia coli phage K1F endosialidase CIMCD self-cleaving protein 66 3 1 3
SP S59 nucleoporin 145 1199 11 1 6
SR S60 lactoferrin 1127 11 1 5
SS S66 murein tetrapeptidase LD-carboxypeptidase (Pseudomonas-type) 3553 3 2 4
ST S54 rhomboid-1 (Diptera) 13494 53 1 3
unassigned S48 HetR putative peptidase 88 1 1 1
unassigned S62 influenza A PA peptidase 52 1 1 3
unassigned S68 PIDD auto-processing protein unit 1 171 2 1 -
unassigned S71 MUC1 self-cleaving mucin 672 2 1 1
unassigned S72 dystroglycan 367 2 1 1
unassigned S79 CARD8 self-cleaving protein 540 7 1 1
unassigned S81 destabilase 353 1 1 1
unassigned S85 small protease (Pseudomonas aeruginosa) 39 1 1 1
Threonine Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
PB T1 archaean proteasome, beta component 22650 62 3 39
PB T2 glycosylasparaginase precursor 3990 9 2 6
PB T3 gamma-glutamyltransferase 1 (bacterial-type) 8667 30 5 4
PB T7 CwpV (Clostridium difficile) self-cleaving threonine peptidase 5 1 1 -
PE T5 ornithine acetyltransferase precursor 3774 2 2 2
unassigned T8 HopB1 g.p. (Pseudomonas syringae) 323 1 1 -
Unknown Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
unassigned U32 collagenase (Porphyromonas-type) 2733 6 1 2
unassigned U40 protein P5 murein endopeptidase (bacteriophage phi-6) 2 1 1 1
unassigned U49 Lit peptidase 10 1 1 -
unassigned U56 homomultimeric peptidase 238 1 1 2
unassigned U57 yabG protein (Bacillus-type) 204 1 1 -
unassigned U69 AIDA-I self-cleaving autotransporter protein (Escherichia coli) 664 2 1 2
unassigned U72 Dop isopeptidase 538 1 1 2
unassigned U74 neprosin 2091 1 1 -
Unclassifiable Peptidases
Clan Family Example Sequences Identifiers Identifiers with EC numbers Identifiers with PDB entries
unassignable unassignable 5 4 25 -