$VAR1 = undef;

Summary for peptidase M01.024: ERAP2 aminopeptidase

Names
MEROPS Name	ERAP2 aminopeptidase
Other names	aminopeptidase MAMS, L-RAP, endoplasmic reticulum aminopeptidase 2 (ERAP2), leukocyte-derived arginine aminopeptidase, Mername-AA066 peptidase

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(E) >> Family M1 >> Subfamily (none) >> M01.024
Holotype	ERAP2 aminopeptidase (Homo sapiens), Uniprot accession Q6P179 (peptidase unit: 281-499), MERNUM MER0002968
History	Identifier created: MEROPS 5.61 (29 October 2001)

Activity
Catalytic type	Metallo
NC-IUBMB	Not yet included in IUBMB recommendations.
Other databases	TREEFAM	http://www.treefam.org/family/TF300395
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/--/p/p/gp (based on 27 cleavages)

Specificity matrix

Amino acid	P1	P1'	P2'	P3'	P4'
Gly	0	1	1	3	8
Pro	0	0	8	9	4
Ala	2	2	0	0	0
Val	1	3	3	1	1
Leu	1	0	0	0	0
Ile	2	4	2	2	0
Met	0	0	0	0	0
Phe	2	0	0	1	2
Tyr	3	3	1	2	2
Trp	0	0	0	0	0
Ser	0	0	0	0	0
Thr	4	4	3	1	0
Cys	0	0	0	0	0
Asn	2	0	0	0	0
Gln	1	1	2	1	2
Asp	1	1	1	1	1
Glu	0	0	0	0	0
Lys	4	0	0	0	0
Arg	4	3	1	1	1
His	0	1	1	1	1

Human genetics
Gene symbol	Locus	Megabases	Ensembl	Entrez gene	Gene Cards	OMIM
ERAP2	5q15		ENSG00000164308	64167		609497