$VAR1 = undef;

Summary for peptidase M12.244: ADAM33 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

Names
MEROPS NameADAM33 peptidase
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.244
HolotypeADAM33 peptidase (Mus musculus), Uniprot accession Q923W9 (peptidase unit: 207-410), MERNUM MER0015147
History Identifier created: MEROPS 6.0 (30 August 2002)
Activity
Catalytic typeMetallo
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (3 cleavages)
Activity statushuman: active (Zou et al., 2004)
mouse: putative
Pharmaceutical relevanceThere is evidence that polymorphisms in ADAM33 predispose to asthma (Van Eerdewegh et al., 2002; Howard et al., 2003; Werner et al., 2004).
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/ADAM33
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
ADAM33 20p13 ENSG00000149451 80332 607114
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Adam33 2:F2 ENSMUSG00000027318 110751 MGI:1341813