Families of Proteolytic Enzymes
A family is a set of homologous proteolytic enzymes. The homology is shown by a significant similarity in amino acid sequence either to the type enzyme of the family, or to another protein that has already been shown to be homologous to the type enzyme, and thus a member of the family. The relationship must exist in the peptidase unit at least. A family can contain a single enzyme if no homologues are known, and a single gene product such as a virus polyprotein can contain more than one proteolytic enzyme each assigned to a different family. Each family is identified by a letter representing the catalytic type of the proteolytic enzymes it contains together with a unique number. Some families are divided into subfamilies because there is evidence of a very ancient divergence within the family, e.g. S1A, S1B.
| Aspartic (A) Peptidases | ||
|---|---|---|
| FAMILY | SUBFAMILY | TYPE ENZYME |
| A1 | A1A | pepsin A (Homo sapiens) |
| A1B | nepenthesin (Nepenthes gracilis) | |
| A2 | A2A | HIV-1 retropepsin (human immunodeficiency virus 1) |
| A2B | Ty3 transposon peptidase (Saccharomyces cerevisiae) | |
| A2C | Gypsy transposon peptidase (Drosophila melanogaster) | |
| A2D | Osvaldo retrotransposon peptidase (Drosophila buzzatii) | |
| A3 | A3A | cauliflower mosaic virus-type peptidase (cauliflower mosaic virus) |
| A3B | bacilliform virus peptidase (rice tungro bacilliform virus) | |
| A5 | thermopsin (Sulfolobus acidocaldarius) | |
| A8 | signal peptidase II (Escherichia coli) | |
| A9 | spumapepsin (human spumaretrovirus) | |
| A11 | A11A | Copia transposon peptidase (Drosophila melanogaster) |
| A11B | Ty1 transposon peptidase (Saccharomyces cerevisiae) | |
| A22 | A22A | presenilin 1 (Homo sapiens) |
| A22B | impas 1 peptidase (Homo sapiens) | |
| A24 | A24A | type 4 prepilin peptidase 1 (Pseudomonas aeruginosa) |
| A24B | FlaK peptidase (Methanococcus maripaludis) | |
| A25 | gpr peptidase (Bacillus megaterium) | |
| A26 | omptin (Escherichia coli) | |
| A28 | A28A | DNA-damage inducible protein 1 (Saccharomyces cerevisiae) |
| A28B | skin SASPase (Mus musculus) | |
| A31 | HybD peptidase (Escherichia coli) | |
| A32 | PerP peptidase (Caulobacter crescentus) | |
| A36 | sporulation factor SpoIIGA (Bacillus subtilis) | |
| A37 | sso1175 g.p. (Sulfolobus solfataricus) | |
| Cysteine (C) Peptidases | ||
| FAMILY | SUBFAMILY | TYPE ENZYME |
| C1 | C1A | papain (Carica papaya) |
| C1B | bleomycin hydrolase (Saccharomyces cerevisiae) | |
| C2 | C2A | calpain-2 (Homo sapiens) |
| C3 | C3A | poliovirus-type picornain 3C (human poliovirus 1) |
| C3B | enterovirus picornain 2A (human poliovirus 1) | |
| C3C | foot-and-mouth disease virus picornain 3C (foot-and-mouth disease virus) | |
| C3D | cowpea mosaic comovirus-type picornain 3C (cowpea mosaic virus) | |
| C3E | hepatitis A virus-type picornain 3C (hepatitis A virus) | |
| C3F | parechovirus picornain 3C (human parechovirus 1) | |
| C3G | rice tungro spherical virus-type peptidase (rice tungro spherical virus) | |
| C3H | grapevine fanleaf-type nepovirus picornain 3C (grapevine fanleaf virus) | |
| C4 | nuclear-inclusion-a peptidase (plum pox virus) | |
| C5 | adenain (human adenovirus type 2) | |
| C6 | potato virus Y-type helper component peptidase (potato virus Y) | |
| C7 | chestnut blight fungus virus p29 peptidase (Cryphonectria hypovirus) | |
| C8 | chestnut blight fungus virus p48 peptidase (Cryphonectria hypovirus 1) | |
| C9 | sindbis virus-type nsP2 peptidase (Sindbis virus) | |
| C10 | streptopain (Streptococcus pyogenes) | |
| C11 | C11A | clostripain (Clostridium histolyticum) |
| C11B | PNT1 peptidase (Trypanosoma brucei) | |
| C12 | ubiquitinyl hydrolase-L1 (Homo sapiens) | |
| C13 | legumain (Canavalia ensiformis) | |
| C14 | C14A | caspase-1 (Rattus norvegicus) |
| C14B | metacaspase Yca1 (Saccharomyces cerevisiae) | |
| C15 | pyroglutamyl-peptidase I (Bacillus amyloliquefaciens) | |
| C16 | C16A | murine hepatitis coronavirus papain-like peptidase 1 (murine hepatitis virus) |
| C16B | mouse hepatitis coronavirus papain-like peptidase 2 (murine hepatitis virus) | |
| C18 | hepatitis C virus peptidase 2 (hepatitis C virus) | |
| C19 | ubiquitin-specific peptidase 14 (Homo sapiens) | |
| C21 | tymovirus peptidase (turnip yellow mosaic virus) | |
| C23 | carlavirus peptidase (apple stem pitting virus) | |
| C24 | rabbit hemorrhagic disease virus 3C-like peptidase (rabbit hemorrhagic disease virus) | |
| C25 | gingipain RgpA (Porphyromonas gingivalis) | |
| C26 | gamma-glutamyl hydrolase (Rattus norvegicus) | |
| C27 | rubella virus peptidase (Rubella virus) | |
| C28 | foot-and-mouth disease virus L-peptidase (foot-and-mouth disease virus) | |
| C30 | porcine transmissible gastroenteritis virus-type main peptidase (transmissible gastroenteritis virus) | |
| C31 | porcine reproductive and respiratory syndrome arterivirus-type cysteine peptidase alpha (lactate-dehydrogenase-elevating virus) | |
| C32 | equine arteritis virus-type cysteine peptidase (porcine reproductive and respiratory syndrome virus) | |
| C33 | equine arteritis virus Nsp2-type cysteine peptidase (equine arteritis virus) | |
| C36 | beet necrotic yellow vein furovirus-type papain-like peptidase (beet necrotic yellow vein virus) | |
| C37 | calicivirin (Southampton virus) | |
| C39 | bacteriocin-processing peptidase (Pediococcus acidilactici) | |
| C40 | dipeptidyl-peptidase VI (Lysinibacillus sphaericus) | |
| C42 | beet yellows virus-type papain-like peptidase (beet yellows virus) | |
| C44 | amidophosphoribosyltransferase precursor (Homo sapiens) | |
| C45 | acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase precursor (Penicillium chrysogenum) | |
| C46 | hedgehog protein (Drosophila melanogaster) | |
| C47 | staphopain A (Staphylococcus aureus) | |
| C48 | Ulp1 peptidase (Saccharomyces cerevisiae) | |
| C49 | Strawberry mottle virus 3C-like peptidase (strawberry mottle virus) | |
| C50 | separase (Saccharomyces cerevisiae) | |
| C51 | D-alanyl-glycyl peptidase (Staphylococcus aureus) | |
| C53 | pestivirus Npro peptidase (classical swine fever virus) | |
| C54 | autophagin-1 (Homo sapiens) | |
| C55 | YopJ protein (Yersinia pseudotuberculosis) | |
| C56 | PfpI peptidase (Pyrococcus furiosus) | |
| C57 | vaccinia virus I7L processing peptidase (Vaccinia virus) | |
| C58 | C58A | YopT peptidase (Yersinia pestis) |
| C58B | HopN1 peptidase (Pseudomonas syringae) | |
| C59 | penicillin V acylase precursor (Lysinibacillus sphaericus) | |
| C60 | C60A | sortase A (Staphylococcus aureus) |
| C60B | sortase B (Staphylococcus aureus) | |
| C62 | gill-associated virus 3C-like peptidase (gill-associated virus) | |
| C63 | African swine fever virus processing peptidase (African swine fever virus) | |
| C64 | Cezanne peptidase (Homo sapiens) | |
| C65 | otubain-1 (Homo sapiens) | |
| C66 | IdeS peptidase (Streptococcus pyogenes) | |
| C67 | CylD peptidase (Homo sapiens) | |
| C69 | dipeptidase A (Lactobacillus helveticus) | |
| C70 | AvrRpt2 peptidase (Pseudomonas syringae) | |
| C71 | pseudomurein endoisopeptidase Pei (Methanobacterium phage psiM2) | |
| C74 | pestivirus NS2 peptidase (bovine viral diarrhea virus 1) | |
| C75 | AgrB peptidase (Staphylococcus aureus) | |
| C76 | viral tegument protein deubiquitinylating peptidase (human herpesvirus 1) | |
| C78 | C78A | UfSP1 peptidase (Mus musculus) |
| C78B | ZUP1 g.p. (Homo sapiens) | |
| C79 | ElaD peptidase (Escherichia coli) | |
| C80 | RTX self-cleaving toxin (Vibrio cholerae) | |
| C82 | C82A | L,D-transpeptidase (Enterococcus faecium) |
| C82B | ykuD transpeptidase (Bacillus subtilis) | |
| C83 | gamma-glutamylcysteine dipeptidyltranspeptidase (Nostoc sp. PCC 7120) | |
| C84 | prtH peptidase (Tannerella forsythia) | |
| C85 | C85A | OTUD5 peptidase (Homo sapiens) |
| C85B | OTU1 peptidase (Saccharomyces cerevisiae) | |
| C86 | ataxin-3 (Homo sapiens) | |
| C87 | nairovirus deubiquitinylating peptidase (Crimean-Congo hemorrhagic fever virus) | |
| C89 | acid ceramidase precursor (Homo sapiens) | |
| C93 | LapG peptidase (Pseudomonas fluorescens) | |
| C95 | lysosomal 66.3 kDa protein (Mus musculus) | |
| C96 | McjB peptidase (Escherichia coli) | |
| C97 | desumoylating isopeptidase 1 (Mus musculus) | |
| C98 | USPL1 peptidase (Homo sapiens) | |
| C99 | iflavirus processing peptidase (Ectropis obliqua picorna-like virus) | |
| C100 | agglutinin peptidase (Marasmius oreades) | |
| C101 | OTULIN peptidase (Homo sapiens) | |
| C102 | GtgE peptidase (Salmonella enterica) | |
| C103 | HopX1 peptidase } (Pseudomonas syringae) | |
| C105 | papain-like peptidase 1 alpha (simian hemorrhagic fever virus) | |
| C106 | archaeosortase A (Haloferax volcanii) | |
| C108 | Prp peptidase (Staphylococcus aureus) | |
| C110 | kyphoscoliosis peptidase (Mus musculus) | |
| C111 | coagulation factor XIIIa (Homo sapiens) | |
| C113 | IgdE peptidase (Streptococcus suis) | |
| C115 | MINDY-1 protein (Homo sapiens) | |
| C116 | dermonecrotic toxin (Pasteurella multocida) | |
| C117 | SpvD g.p. (Salmonella typhimurium) | |
| C118 | EspL g.p. (Escherichia coli) | |
| C119 | LotA g.p. (Legionella pneumophila) | |
| C121 | MINDY-4 peptidase (Homo sapiens) | |
| C122 | SdeA (Legionella pneumophila) | |
| C123 | RARP2 (Rickettsia rickettsii) | |
| C124 | Lem27 (Legionella pneumophila) | |
| Glutamic (G) Peptidases | ||
| FAMILY | SUBFAMILY | TYPE ENZYME |
| G1 | scytalidoglutamic peptidase (Scytalidium lignicolum) | |
| G2 | pre-neck appendage protein (bacteriophage phi-29) | |
| G3 | strawberry mottle virus glutamic peptidase (strawberry mottle virus) | |
| G4 | Tiki1 peptidase (Homo sapiens) | |
| G5 | RCE1 peptidase (Saccharomyces cerevisiae) | |
| G6 | Ras/Rap1-specific peptidase (Vibrio vulnificus) | |
| Metallo (M) Peptidases | ||
| FAMILY | SUBFAMILY | TYPE ENZYME |
| M1 | aminopeptidase N (Homo sapiens) | |
| M2 | angiotensin-converting enzyme peptidase unit 1 (Homo sapiens) | |
| M3 | M3A | thimet oligopeptidase (Rattus norvegicus) |
| M3B | oligopeptidase F (Lactococcus lactis) | |
| M3C | Pz-peptidase A (Geobacillus sp. MO-1) | |
| M4 | thermolysin (Bacillus thermoproteolyticus) | |
| M5 | mycolysin (Streptomyces cacaoi) | |
| M6 | immune inhibitor A peptidase (Bacillus thuringiensis) | |
| M7 | snapalysin (Streptomyces lividans) | |
| M8 | leishmanolysin (Leishmania major) | |
| M9 | M9A | collagenase V (Vibrio alginolyticus) |
| M9B | bacterial collagenase H (Clostridium histolyticum) | |
| M10 | M10A | matrix metallopeptidase-1 (Homo sapiens) |
| M10B | serralysin (Serratia marcescens) | |
| M10C | fragilysin (Bacteroides fragilis) | |
| M11 | gametolysin (Chlamydomonas reinhardtii) | |
| M12 | M12A | astacin (Astacus astacus) |
| M12B | adamalysin (Crotalus adamanteus) | |
| M13 | neprilysin (Homo sapiens) | |
| M14 | M14A | carboxypeptidase A1 (Homo sapiens) |
| M14B | carboxypeptidase E (Bos taurus) | |
| M14C | gamma-D-glutamyl--meso-diaminopimelate peptidase I (Lysinibacillus sphaericus) | |
| M14D | cytosolic carboxypeptidase 6 (Homo sapiens) | |
| M15 | M15A | zinc D-Ala-D-Ala carboxypeptidase (Streptomyces albus) |
| M15B | vanY D-Ala-D-Ala carboxypeptidase (Enterococcus faecium) | |
| M15C | Ply118 L-Ala-D-Glu peptidase (bacteriophage A118) | |
| M15D | vanX D-Ala-D-Ala dipeptidase (Enterococcus faecium) | |
| M16 | M16A | pitrilysin (Escherichia coli) |
| M16B | mitochondrial processing peptidase beta-subunit (Saccharomyces cerevisiae) | |
| M16C | eupitrilysin (Homo sapiens) | |
| M17 | leucyl aminopeptidase 3 (Bos taurus) | |
| M18 | aminopeptidase I (Saccharomyces cerevisiae) | |
| M19 | membrane dipeptidase (Homo sapiens) | |
| M20 | M20A | glutamate carboxypeptidase (Pseudomonas sp.) |
| M20B | peptidase T (Escherichia coli) | |
| M20C | Xaa-His dipeptidase (Escherichia coli) | |
| M20D | carboxypeptidase Ss1 (Sulfolobus solfataricus) | |
| M20F | carnosine dipeptidase II (Mus musculus) | |
| M23 | M23A | beta-lytic metallopeptidase (Achromobacter lyticus) |
| M23B | lysostaphin (Staphylococcus simulans) | |
| M24 | M24A | methionyl aminopeptidase 1 (Escherichia coli) |
| M24B | aminopeptidase P (Escherichia coli) | |
| M26 | IgA1-specific metallopeptidase (Streptococcus sanguinis) | |
| M27 | tentoxilysin (Clostridium tetani) | |
| M28 | M28A | aminopeptidase S (Streptomyces griseus) |
| M28B | glutamate carboxypeptidase II (Homo sapiens) | |
| M28C | IAP aminopeptidase (Escherichia coli) | |
| M28D | aminopeptidase ES-62 (Acanthocheilonema viteae) | |
| M28E | aminopeptidase Ap1 (Vibrio proteolyticus) | |
| M28F | YwaD peptidase (Bacillus subtilis) | |
| M29 | aminopeptidase T (Thermus aquaticus) | |
| M30 | hyicolysin (Staphylococcus hyicus) | |
| M32 | carboxypeptidase Taq (Thermus aquaticus) | |
| M34 | anthrax lethal factor (Bacillus anthracis) | |
| M35 | deuterolysin (Aspergillus flavus) | |
| M36 | fungalysin (Aspergillus fumigatus) | |
| M38 | isoaspartyl dipeptidase (Escherichia coli) | |
| M41 | FtsH peptidase (Escherichia coli) | |
| M42 | glutamyl aminopeptidase (Lactococcus lactis) | |
| M43 | M43A | cytophagalysin (Cytophaga sp.) |
| M43B | pappalysin-1 (Homo sapiens) | |
| M44 | pox virus metallopeptidase (Vaccinia virus) | |
| M48 | M48A | Ste24 peptidase (Saccharomyces cerevisiae) |
| M48B | HtpX peptidase (Escherichia coli) | |
| M48C | Oma1 peptidase (Saccharomyces cerevisiae) | |
| M49 | dipeptidyl-peptidase III (Rattus norvegicus) | |
| M50 | M50A | site 2 peptidase (Homo sapiens) |
| M50B | sporulation factor SpoIVFB (Bacillus subtilis) | |
| M54 | archaelysin (Methanocaldococcus jannaschii) | |
| M55 | D-aminopeptidase DppA (Bacillus subtilis) | |
| M56 | BlaR1 peptidase (Staphylococcus aureus) | |
| M57 | prtB g.p. (Myxococcus xanthus) | |
| M60 | enhancin (Lymantria dispar nucleopolyhedrovirus) | |
| M61 | glycyl aminopeptidase (Sphingomonas capsulata) | |
| M64 | IgA peptidase (Clostridium ramosum) | |
| M66 | StcE peptidase (Escherichia coli) | |
| M67 | M67A | PSMD14 peptidase (Saccharomyces cerevisiae) |
| M67B | JAMM-like protein (Archaeoglobus fulgidus) | |
| M67C | STAMBP isopeptidase (Homo sapiens) | |
| M72 | peptidyl-Asp metallopeptidase (Pseudomonas aeruginosa) | |
| M73 | camelysin (Bacillus cereus) | |
| M74 | murein endopeptidase (Escherichia coli) | |
| M75 | imelysin (Pseudomonas aeruginosa) | |
| M76 | Atp23 peptidase (Homo sapiens) | |
| M77 | tryptophanyl aminopeptidase 7-DMATS-type peptidase (Aspergillus fumigatus) | |
| M78 | ImmA peptidase (Bacillus subtilis) | |
| M80 | Wss1 peptidase (Saccharomyces cerevisiae) | |
| M81 | microcystinase MlrC (Sphingomonas sp. ACM-3962) | |
| M82 | PrsW peptidase (Bacillus subtilis) | |
| M84 | MpriBi peptidase (Bacillus intermedius) | |
| M85 | NleC peptidase (Escherichia coli) | |
| M86 | PghP gamma-polyglutamate hydrolase (Bacillus phage phiNIT1) | |
| M87 | chloride channel accessory protein 1 (Homo sapiens) | |
| M88 | IMPa peptidase (Pseudomonas aeruginosa) | |
| M90 | MtfA peptidase (Escherichia coli) | |
| M91 | NleD peptidase (Escherichia coli) | |
| M93 | BACCAC_01431 g.p. and similar (Bacteroides caccae) | |
| M95 | abylysin (Pyrococcus abyssi) | |
| M97 | EcxAB peptidase (Escherichia coli) | |
| M98 | YghJ g.p. (Escherichia coli) | |
| M99 | Csd4 peptidase (Helicobacter pylori) | |
| M100 | spartan peptidase (Homo sapiens) | |
| M102 | DA1 peptidase (Arabidopsis thaliana) | |
| M103 | TldD peptidase (Escherichia coli) | |
| M105 | MAP1 peptidase (Myxococcus xanthus) | |
| M106 | FP0506 g.p. (Flavobacterium psychrophilum) | |
| Asparagine (N) Peptide Lyases | ||
| FAMILY | SUBFAMILY | TYPE ENZYME |
| N1 | nodavirus peptide lyase (flock house virus) | |
| N2 | tetravirus coat protein (Nudaurelia capensis omega virus) | |
| N4 | Tsh-associated self-cleaving domain and similar (Escherichia coli) | |
| N5 | picobirnavirus self-cleaving protein (Human picobirnavirus) | |
| N6 | YscU protein (Yersinia pseudotuberculosis) | |
| N7 | reovirus type 1 coat protein (Mammalian orthoreovirus 1) | |
| N8 | poliovirus capsid VP0-type self-cleaving protein (human poliovirus 1) | |
| N9 | intein-containing V-type proton ATPase catalytic subunit A (Saccharomyces cerevisiae) | |
| N10 | intein-containing replicative DNA helicase precursor (Synechocystis sp. PCC 6803) | |
| N11 | intein-containing chloroplast ATP-dependent peptide lyase (Chlamydomonas eugametos) | |
| Mixed (P) Peptidases | ||
| FAMILY | SUBFAMILY | TYPE ENZYME |
| P1 | DmpA aminopeptidase (Ochrobactrum anthropi) | |
| P2 | P2A | EGF-like module containing mucin-like hormone receptor-like 2 (Homo sapiens) |
| P2B | polycystin-1 (Homo sapiens) | |
| Serine (S) Peptidases | ||
| FAMILY | SUBFAMILY | TYPE ENZYME |
| S1 | S1A | chymotrypsin A (Bos taurus) |
| S1B | glutamyl endopeptidase I (Staphylococcus aureus) | |
| S1C | DegP peptidase (Escherichia coli) | |
| S1D | lysyl endopeptidase (Achromobacter lyticus) | |
| S1E | streptogrisin A (Streptomyces griseus) | |
| S3 | togavirin (Sindbis virus) | |
| S6 | IgA1-specific serine peptidase (Neisseria gonorrhoeae) | |
| S7 | flavivirin (yellow fever virus) | |
| S8 | S8A | subtilisin Carlsberg (Bacillus licheniformis) |
| S8B | kexin (Saccharomyces cerevisiae) | |
| S9 | S9A | prolyl oligopeptidase (Sus scrofa) |
| S9B | dipeptidyl-peptidase IV (Homo sapiens) | |
| S9C | acylaminoacyl-peptidase (Homo sapiens) | |
| S9D | glutamyl endopeptidase C (Arabidopsis thaliana) | |
| S10 | carboxypeptidase Y (Saccharomyces cerevisiae) | |
| S11 | D-Ala-D-Ala carboxypeptidase A (Geobacillus stearothermophilus) | |
| S12 | D-Ala-D-Ala carboxypeptidase B (Streptomyces lividans) | |
| S13 | D-Ala-D-Ala peptidase C (Escherichia coli) | |
| S14 | peptidase Clp (Escherichia coli) | |
| S15 | Xaa-Pro dipeptidyl-peptidase (Lactococcus lactis) | |
| S16 | Lon-A peptidase (Escherichia coli) | |
| S21 | cytomegalovirus assemblin (human herpesvirus 5) | |
| S24 | repressor LexA (Escherichia coli) | |
| S26 | S26A | signal peptidase I (Escherichia coli) |
| S26B | signalase 21 kDa component (Saccharomyces cerevisiae) | |
| S26C | TraF peptidase (Escherichia coli) | |
| S28 | lysosomal Pro-Xaa carboxypeptidase (Homo sapiens) | |
| S29 | hepacivirin (hepatitis C virus) | |
| S30 | potyvirus P1 peptidase (plum pox virus) | |
| S31 | pestivirus NS3 polyprotein peptidase (bovine viral diarrhea virus 1) | |
| S32 | equine arteritis virus serine peptidase (equine arteritis virus) | |
| S33 | prolyl aminopeptidase (Neisseria gonorrhoeae) | |
| S37 | PS-10 peptidase (Streptomyces lividans) | |
| S39 | S39A | sobemovirus peptidase (cocksfoot mottle virus) |
| S39B | luteovirus peptidase (potato leaf roll luteovirus) | |
| S41 | S41A | C-terminal processing peptidase-1 (Escherichia coli) |
| S41B | tricorn core peptidase (Thermoplasma acidophilum) | |
| S45 | penicillin G acylase precursor (Escherichia coli) | |
| S46 | dipeptidyl-peptidase 7 (Porphyromonas gingivalis) | |
| S48 | HetR putative peptidase (Anabaena variabilis) | |
| S49 | S49A | signal peptide peptidase A (Escherichia coli) |
| S49B | protein C (bacteriophage lambda) | |
| S49C | archaean signal peptide peptidase 1 (Pyrococcus horikoshii) | |
| S50 | infectious pancreatic necrosis birnavirus Vp4 peptidase (infectious pancreatic necrosis virus) | |
| S51 | dipeptidase E (Escherichia coli) | |
| S53 | sedolisin (Pseudomonas sp. 101) | |
| S54 | rhomboid-1 (Drosophila melanogaster) | |
| S55 | SpoIVB peptidase (Bacillus subtilis) | |
| S59 | nucleoporin 145 (Homo sapiens) | |
| S60 | lactoferrin (Homo sapiens) | |
| S62 | influenza A PA peptidase (influenza A virus) | |
| S64 | Ssy5 peptidase (Saccharomyces cerevisiae) | |
| S65 | picornain-like serine peptidase (Breda virus) | |
| S66 | murein tetrapeptidase LD-carboxypeptidase (Pseudomonas aeruginosa) | |
| S68 | PIDD auto-processing protein unit 1 (Homo sapiens) | |
| S69 | Tellina virus 1 VP4 peptidase (Tellina virus 1) | |
| S71 | MUC1 self-cleaving mucin (Homo sapiens) | |
| S72 | dystroglycan (Homo sapiens) | |
| S73 | gpO peptidase (Enterobacteria phage P2) | |
| S74 | Escherichia coli phage K1F endosialidase CIMCD self-cleaving protein (Enterobacteria phage K1F) | |
| S75 | White bream virus serine peptidase (White bream virus) | |
| S77 | prohead peptidase gp21 (Enterobacteria phage T4) | |
| S78 | prohead peptidase (Enterobacteria phage HK97) | |
| S79 | CARD8 self-cleaving protein (Homo sapiens) | |
| S80 | prohead peptidase gp175 (Pseudomonas phage phiKZ) | |
| S81 | destabilase (Hirudo medicinalis) | |
| S82 | autocrine proliferation repressor protein A (Dictyostelium discoideum) | |
| S85 | small protease (Pseudomonas aeruginosa) | |
| Threonine (T) Peptidases | ||
| FAMILY | SUBFAMILY | TYPE ENZYME |
| T1 | T1A | archaean proteasome, beta component (Thermoplasma acidophilum) |
| T1B | HslV component of HslUV peptidase (Escherichia coli) | |
| T2 | glycosylasparaginase precursor (Homo sapiens) | |
| T3 | gamma-glutamyltransferase 1 (Escherichia coli) | |
| T5 | ornithine acetyltransferase precursor (Saccharomyces cerevisiae) | |
| T7 | CwpV self-cleaving threonine peptidase (Clostridium difficile) | |
| T8 | HopB1 g.p. (Pseudomonas syringae) | |
| Peptidases of Unknown Catalytic Type | ||
| FAMILY | SUBFAMILY | TYPE ENZYME |
| U32 | collagenase (Porphyromonas gingivalis) | |
| U40 | protein P5 murein endopeptidase (bacteriophage phi-6) | |
| U49 | Lit peptidase (Escherichia coli) | |
| U56 | homomultimeric peptidase (Thermotoga maritima) | |
| U57 | yabG protein (Bacillus subtilis) | |
| U69 | AIDA-I self-cleaving autotransporter protein (Escherichia coli) | |
| U72 | Dop isopeptidase (Mycobacterium tuberculosis) | |
