$VAR1 = undef;

Summary for peptidase S01.306: kallikrein-related peptidase 13

Names
MEROPS Name	kallikrein-related peptidase 13
Other names	KLK-L4 [obs.] g.p. (Homo sapiens), kallikrein 13, kallikrein-like protein 4 (Homo sapiens), KLK13 g.p. (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.306
Holotype	kallikrein-related peptidase 13 (Homo sapiens), Uniprot accession Q9UKR3 (peptidase unit: 26-241), MERNUM MER0005269
History	Identifier created: MEROPS 3.30 (20 July 1999)

Activity
Catalytic type	Serine
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.119
Enzymology	BRENDA database
Proteolytic events	CutDB database (1 cleavage)
Activity status	human: active (Kapadia et al., 2004) mouse: active (by similarity to human)
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/KLK13
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	v/r/sl/Ril/-/g/g (based on 21 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	3	0	0	0	2	2	5	7
Pro	1	0	2	0	0	2	0	1
Ala	2	2	3	0	1	0	0	1
Val	5	0	0	0	0	5	0	0
Leu	0	1	4	1	4	2	0	0
Ile	3	0	0	0	7	3	0	1
Met	0	0	0	0	0	0	0	0
Phe	0	0	2	0	1	1	0	0
Tyr	2	1	0	0	0	0	0	1
Trp	0	0	0	0	0	0	0	0
Ser	1	2	5	0	1	0	1	0
Thr	0	1	2	0	2	1	2	1
Cys	0	0	0	0	1	1	1	1
Asn	0	0	2	0	0	1	2	3
Gln	0	3	0	0	0	0	2	0
Asp	1	2	0	0	0	0	0	1
Glu	2	1	0	0	0	0	0	0
Lys	0	0	0	3	0	0	3	1
Arg	0	8	1	17	0	1	2	0
His	0	0	0	0	0	0	1	1