Summary for peptidase S01.029: kallikrein-related peptidase 14

Names
MEROPS Name	kallikrein-related peptidase 14
Other names	kallikrein 14, kallikrein-like protein 6, KLK-L6 [obs.] g.p. (Homo sapiens), KLK-14 g.p. (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.029
Holotype	kallikrein-related peptidase 14 (Homo sapiens), Uniprot accession Q9P0G3 (peptidase unit: 41-265), MERNUM MER0011038
History	Identifier created: MEROPS 5.0 (17 April 2000)

Activity
Catalytic type	Serine
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (32 cleavages)
Activity status	human: putative mouse: putative
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/KLK14
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/R-/-/-/g (based on 79 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	3	10	12	2	6	3	11	16
Pro	6	3	17	0	1	2	4	9
Ala	6	1	4	0	5	3	2	1
Val	2	4	2	0	4	12	3	3
Leu	4	7	3	1	4	8	3	4
Ile	7	3	2	0	15	8	3	0
Met	0	0	0	0	1	0	0	0
Phe	2	2	3	1	0	4	2	1
Tyr	1	1	0	5	4	1	2	2
Trp	0	0	0	0	0	0	1	2
Ser	5	6	13	0	9	6	1	1
Thr	8	7	7	0	2	1	6	5
Cys	0	2	3	0	1	0	0	1
Asn	1	3	4	0	1	1	7	2
Gln	3	12	0	0	0	1	4	3
Asp	4	4	2	0	3	5	2	3
Glu	3	4	2	0	1	1	3	1
Lys	4	3	3	12	3	2	4	1
Arg	4	5	2	58	2	4	4	2
His	0	0	0	0	2	2	2	0