Summary for peptidase M16.009: eupitrilysin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

 

Names
MEROPS Nameeupitrilysin
Other namesMername-AA013 peptidase, presequence protease (Homo sapiens), hPreP, metalloprotease 1, peptidasome, pitrilysin-like metalloprotease, PITRM1 g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan ME >> Subclan (none) >> Family M16 >> Subfamily C >> M16.009
Holotypeeupitrilysin (Homo sapiens), Uniprot accession Q5JRX3 (peptidase unit: 96-243), MERNUM MER0004877
History Identifier created: MEROPS 3.1 (22 December 1998)
Activity
Catalytic typeMetallo
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (31 cleavages)
Activity statushuman: active (Mzhavia et al., 1999)
mouse: putative
Other databases TREEFAMhttp://www.treefam.org/family/TF300333
PANTHERhttp://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR43016:SF3
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/v/-/-Scissile bond-/-/-/- (based on 60 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 3 1 5 8 6 7 4 3
Pro 2 2 1 3 1 0 4 0
Ala 2 0 0 2 5 1 2 3
Val 6 16 9 1 6 11 6 2
Leu 4 4 4 4 5 6 2 8
Ile 1 5 1 0 5 4 1 2
Met 1 1 1 0 3 3 0 1
Phe 3 2 7 8 9 1 8 5
Tyr 3 1 1 8 0 1 1 1
Trp 0 0 0 0 0 0 0 2
Ser 2 1 0 2 4 6 2 1
Thr 1 0 6 6 2 1 7 4
Cys 1 1 0 1 0 0 0 0
Asn 1 1 3 0 0 1 1 2
Gln 1 7 5 1 1 6 6 1
Asp 2 0 0 2 0 2 3 2
Glu 0 1 2 0 0 2 2 3
Lys 8 2 2 6 6 1 5 3
Arg 10 6 4 7 7 4 0 3
His 1 2 2 0 0 3 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
PITRM1 10p15.2 ENSG00000107959 10531