$VAR1 = undef;

Summary for peptidase M02.006: angiotensin-converting enzyme-2

Names
MEROPS Name	angiotensin-converting enzyme-2
Other names	ACE2, ACEH

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(E) >> Family M2 >> Subfamily (none) >> M02.006
Holotype	angiotensin-converting enzyme-2 (Homo sapiens), Uniprot accession Q9BYF1 (peptidase unit: 17-618), MERNUM MER0011061
History	Identifier created: MEROPS 5.3 (4 December 2000)

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00135
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.17 (Metallocarboxypeptidases) >> Peptidase 3.4.17.23
Enzymology	BRENDA database
Proteolytic events	CutDB database (3 cleavages)
Activity status	human: active (Turner & Hooper, 2004) mouse: active (by similarity)
Physiology	Genetic data show that this peptidase is an essential regulator of heart function at least in rodents and Drosophila (Crackower et al., 2002). Human angiotensin-converting enzyme 2 is a functional receptor for SARS coronavirus (Li et al., 2005).
Pathways	KEGG	Protein digestion and absorption
	KEGG	Renin-angiotensin system
Other databases	TREEFAM	http://www.treefam.org/family/TF312861
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	g/p/-/Pfrl/-/-/- (based on 14 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'
Gly	4	0	0	0	0
Pro	0	5	1	10	0
Ala	1	0	2	0	0
Val	0	1	0	0	0
Leu	0	1	0	1	2
Ile	0	1	0	1	1
Met	0	0	2	0	0
Phe	2	2	1	1	5
Tyr	1	0	1	0	0
Trp	0	0	0	0	0
Ser	0	1	2	0	0
Thr	0	0	0	0	0
Cys	0	0	0	0	0
Asn	0	1	0	0	0
Gln	0	0	1	0	0
Asp	0	1	0	0	0
Glu	1	0	1	0	0
Lys	1	0	2	0	1
Arg	2	0	0	0	3
His	1	0	1	1	0