$VAR1 = undef;

Summary for peptidase M14.006: carboxypeptidase M

Names
MEROPS Name	carboxypeptidase M
Other names	renal carboxypeptidase, urinary carboxypeptidase B

Domain architecture

MEROPS Classification
Classification	Clan MC >> Subclan (none) >> Family M14 >> Subfamily B >> M14.006
Holotype	carboxypeptidase M (Homo sapiens), Uniprot accession P14384 (peptidase unit: 12-313), MERNUM MER0001205
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00211
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.17 (Metallocarboxypeptidases) >> Peptidase 3.4.17.12
Enzymology	BRENDA database
Proteolytic events	CutDB database (3 cleavages)
Activity status	human: active (Skidgel, 2004) mouse: putative (Rehli et al., 2000)
Physiology	May degrade bioactive peptides.
Other databases	TREEFAM	http://www.treefam.org/family/TF315592
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/-RK/-/-/- (based on 11 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'
Gly	2	2	0	2	0
Pro	0	1	1	0	0
Ala	0	1	0	2	0
Val	0	0	0	0	0
Leu	0	0	1	3	0
Ile	0	0	0	0	0
Met	0	0	0	1	0
Phe	1	0	2	1	0
Tyr	0	0	0	1	0
Trp	1	1	0	0	0
Ser	0	2	0	0	0
Thr	1	0	0	0	0
Cys	0	0	0	0	0
Asn	0	0	0	1	0
Gln	0	0	0	0	0
Asp	0	0	0	0	0
Glu	0	0	1	0	0
Lys	1	0	2	0	5
Arg	1	0	0	0	6
His	0	0	0	0	0