Summary for peptidase M12.138: jararhagin

Names
MEROPS Name	jararhagin
Other names	batroxhagin (Bothrops atrox), HF2-proteinase, jararafibrase I, venom endopeptidase Bothrops jararaca

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.138
Holotype	jararhagin (Bothrops jararaca), Uniprot accession P30431 (peptidase unit: 153-355), MERNUM MER0001138
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00181
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.73
Enzymology	BRENDA database
Proteolytic events	CutDB database (27 cleavages)
Physiology	Likely role in snake venom toxicity. Hemorrhagic, anticoagulant.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/eas/-lfav/-/-/- (based on 40 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	1	4	5	3	0	1	3	2
Pro	2	2	0	2	0	0	0	7
Ala	1	4	7	10	5	2	5	2
Val	3	3	2	0	5	7	2	4
Leu	4	2	5	1	16	4	2	2
Ile	3	2	0	0	0	2	0	5
Met	1	1	1	1	3	1	1	1
Phe	0	2	0	2	7	0	2	1
Tyr	0	1	0	1	3	4	0	0
Trp	1	0	0	0	0	0	0	1
Ser	1	2	7	5	0	4	3	4
Thr	3	1	1	3	0	3	6	2
Cys	0	1	0	0	0	1	0	0
Asn	1	0	0	1	0	1	1	1
Gln	1	0	0	0	0	3	0	1
Asp	5	0	2	1	0	0	1	0
Glu	5	5	8	1	1	2	3	2
Lys	3	5	2	5	0	3	8	1
Arg	2	4	0	2	0	2	0	3
His	1	1	0	2	0	0	2	0