Summary for peptidase S01.127: cationic trypsin (Homo sapiens-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

 

Names
MEROPS Namecationic trypsin (Homo sapiens-type)
Other namesPRSS1 g.p. (Homo sapiens), trypsin 1 (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.127
Holotypecationic trypsin (Homo sapiens-type), Uniprot accession P07477 (peptidase unit: 24-246), MERNUM MER0000020
History Identifier created: MEROPS 5.8 (19 March 2002)
Activity
Catalytic typeSerine
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (7 cleavages)
KnockoutHuman hereditary pancreatitis (HP) is a rare, early-onset genetic disorder characterized by epigastric pain and often more serious complications. It is caused by mutations in the gene for cationic trypsinogen. Several different mutations have been detected, and they are associated with variants of the disease (Whitcomb et al., 1996; Gorry et al., 1997; Nishimori et al., 1999).
Pathways KEGGInfluenza A
KEGGNeuroactive ligand-receptor interaction
KEGGPancreatic secretion
KEGGProtein digestion and absorption
Other databases TREEFAMhttp://www.treefam.org/family/TF331065
PANTHERhttp://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR24264:SF12
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
PRSS1 7q35 ENSG00000173636 5644 PRSS1 276000