$VAR1 = undef;

Summary for peptidase M14.012: metallocarboxypeptidase Z

Names
MEROPS Name	metallocarboxypeptidase Z
Other names	carboxypeptidase Z

Domain architecture

MEROPS Classification
Classification	Clan MC >> Subclan (none) >> Family M14 >> Subfamily B >> M14.012
Holotype	metallocarboxypeptidase Z (Homo sapiens), Uniprot accession Q66K79 (peptidase unit: 177-515), MERNUM MER0003428
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Metallo
NC-IUBMB	Not yet included in IUBMB recommendations.
Activity status	human: active (Novikov & Fricker, 1999) mouse: active (Novikova & Fricker, 1999)
Physiology	In chicken embryo, metallocarboxypeptidase Z plays a role in Wnt signaling (Moeller et al., 2003).
Other databases	TREEFAM	http://www.treefam.org/family/TF315592
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/aRK/-/-/- (based on 14 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'
Gly	0	1	0	1	0
Pro	2	1	0	0	0
Ala	2	1	0	4	0
Val	1	1	1	1	0
Leu	1	0	1	2	0
Ile	0	1	1	0	0
Met	0	0	1	0	0
Phe	0	0	3	2	0
Tyr	0	0	0	0	0
Trp	0	0	0	0	0
Ser	0	0	3	2	0
Thr	0	0	1	0	0
Cys	0	0	0	1	0
Asn	0	2	1	0	0
Gln	1	1	0	0	0
Asp	1	0	0	0	0
Glu	1	2	0	0	0
Lys	1	0	2	1	4
Arg	1	0	0	0	10
His	0	1	0	0	0