$VAR1 = undef;

Summary for peptidase S01.273: DegP peptidase

Names
MEROPS Name	DegP peptidase
Other names	high temperature requirement A peptidase, HtrA, protease Do

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily C >> S01.273
Holotype	DegP peptidase (Escherichia coli), Uniprot accession P0C0V0 (peptidase unit: 114-269), MERNUM MER0000266
History	Identifier created: MEROPS 3.30 (20 July 1999)

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00333
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.107
Enzymology	BRENDA database
Physiology	A heat-shock protein in E. coli that is required for growth at elevated temperatures, probably funtioning in the degradation of unfolded proteins.
Pharmaceutical relevance	Reported to be essential for the virulence of pathogenic bacteria including Salmonella enterica serovar typhimurium, Yersia entericolitica and Streptococcus pyogenes (Pallen & Wren, 1997).
Pathways	KEGG	Two-component system
Other databases	PANTHER	http://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR22939:SF109
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/V-/-/-/- (based on 16 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	1	0	1	0	0	1	1	0
Pro	0	1	2	0	0	0	0	1
Ala	4	0	1	0	3	0	0	2
Val	1	0	0	12	0	1	1	0
Leu	1	1	2	0	0	0	0	0
Ile	1	0	0	2	0	0	0	0
Met	0	0	0	0	1	1	2	1
Phe	2	0	1	0	0	1	0	1
Tyr	2	0	0	0	1	1	0	1
Trp	0	0	0	0	0	0	0	0
Ser	1	2	1	0	2	0	1	0
Thr	0	0	0	0	0	0	0	0
Cys	0	0	0	1	0	0	0	0
Asn	0	0	0	0	0	0	0	1
Gln	1	3	1	1	1	0	1	1
Asp	0	1	0	0	0	1	0	0
Glu	0	2	1	0	0	3	2	1
Lys	0	2	2	0	1	1	1	0
Arg	0	2	2	0	1	0	0	0
His	0	0	0	0	0	0	0	0