$VAR1 = undef;

Summary for peptidase C01.073: peptidase 1 (mite)

Names
MEROPS Name	peptidase 1 (mite)
Other names	allergen Der f 1 (Dermatophagoides farinae), antigen Der p 1 (Dermatophagoides pteronyssinus), Der P1, antigen Eur m 1 (Euroglyphus maynei), antigen Pso o 1 (Psoroptes ovis)

Domain architecture

MEROPS Classification
Classification	Clan CA >> Subclan (none) >> Family C1 >> Subfamily A >> C01.073
Holotype	peptidase 1 (mite) (Dermatophagoides pteronyssinus), Uniprot accession P08176 (peptidase unit: 99-320), MERNUM MER0000719
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Cysteine
Peplist	Included in the Peplist with identifier PL00069
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.65
Enzymology	BRENDA database
Proteolytic events	CutDB database (13 cleavages)
Physiology	Allergen, and IgE destruction: role in asthma.
Pharmaceutical relevance	Potential drug target for asthma. Its enzymatic activity has been shown to have pro-inflammatory effects that could also negatively influence efficacy of allergen-specific immunotherapy. The cytokine release induced by this allergen in respiratory epithelial cells is, in part, mediated by activation of protease-activated receptor-2 (Asokananthan et al., 2002).
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/ag/--/-/-/l (based on 29 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	3	3	6	4	3	5	4	2
Pro	4	0	0	0	0	3	3	5
Ala	3	0	7	5	2	2	0	0
Val	3	3	3	0	3	3	0	1
Leu	4	2	3	2	4	1	3	7
Ile	0	0	0	0	2	1	1	0
Met	1	0	0	0	0	1	1	1
Phe	2	3	1	1	3	0	1	0
Tyr	0	0	3	1	0	0	0	0
Trp	0	1	0	0	0	0	0	0
Ser	2	1	2	1	5	5	6	4
Thr	1	1	2	1	3	1	1	2
Cys	0	0	0	0	0	0	0	0
Asn	0	2	0	1	1	2	0	1
Gln	1	3	0	2	0	0	1	0
Asp	2	2	0	2	0	0	0	0
Glu	0	1	2	4	0	2	3	2
Lys	0	6	0	2	1	0	0	1
Arg	1	1	0	3	0	1	2	0
His	0	0	0	0	0	0	1	1