$VAR1 = undef;

Summary for peptidase S28.002: dipeptidyl-peptidase II

Names
MEROPS Name	dipeptidyl-peptidase II
Other names	carboxytripeptidase, dipeptidyl peptidase 2, dipeptidyl aminopeptidase II, dipeptidyl arylamidase II, DPP II, dipeptidyl peptidase VII, quiescent cell proline dipeptidase, DPP7 g.p. (Homo sapiens), DPP2

Domain architecture

MEROPS Classification
Classification	Clan SC >> Subclan (none) >> Family S28 >> Subfamily (none) >> S28.002
Holotype	dipeptidyl-peptidase II (Rattus norvegicus), Uniprot accession Q9EPB1 (peptidase unit: 39-494), MERNUM MER0006058
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00396
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.14 (Dipeptidyl-peptidase and tripeptidyl-peptidases) >> Peptidase 3.4.14.2
Enzymology	BRENDA database
Proteolytic events	CutDB database (1 cleavage)
Activity status	human: active (McDonald & Ohkubo, 2004) mouse: active (by similarity to rat) (Araki et al., 2001)
Other databases	TREEFAM	http://www.treefam.org/family/TF314414
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/Pam-/-/-/- (based on 30 cleavages)

Specificity matrix

Amino acid	P2	P1	P1'	P2'	P3'	P4'
Gly	4	0	2	1	1	0
Pro	2	18	3	3	0	1
Ala	4	7	3	0	0	0
Val	0	0	1	0	0	0
Leu	1	0	0	0	0	0
Ile	0	0	0	0	1	0
Met	2	4	1	0	0	0
Phe	2	0	1	0	2	1
Tyr	1	0	0	0	0	0
Trp	0	0	0	0	0	0
Ser	2	0	0	0	0	0
Thr	0	0	0	0	0	0
Cys	0	0	0	0	0	0
Asn	0	0	0	0	0	0
Gln	0	0	2	1	1	1
Asp	0	0	0	0	0	0
Glu	1	0	1	0	0	0
Lys	5	0	1	0	0	0
Arg	5	0	0	0	0	0
His	1	0	0	0	0	0