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Substrates for peptidase S08.073: PCSK2 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
72 kDa type IV collagenase P08253 96-105 Peptide-Arg101+Cys-Peptide S CS Arg Lys Pro Arg Cys Gly Asn Pro Remacle et al., 2008
A disintegrin and metalloproteinase with thrombospondin motifs 1 Q9UHI8 247-256 Peptide-Arg252+Phe-Peptide S CS Arg Lys Lys Arg Phe Val Ser Ser Remacle et al., 2008
A disintegrin and metalloproteinase with thrombospondin motifs 13 Q76LX8 69-78 Peptide-Arg74+Ala-Peptide S CS Arg Gln Arg Arg Ala Ala Gly Gly Remacle et al., 2008
A disintegrin and metalloproteinase with thrombospondin motifs 2 O95450 82-92 Peptide-Arg88+Ala-Peptide S CS Arg Ala Arg Arg Ala Ala Pro Val Remacle et al., 2008
A disintegrin and metalloproteinase with thrombospondin motifs 4 O75173 207-216 Peptide-Arg212+Phe-Peptide S CS Arg Ala Lys Arg Phe Ala Ser Leu Remacle et al., 2008
Aerolysin P09167 450-459 Peptide-Arg455+Ser-Peptide S CS Arg Arg Ala Arg Ser Val Asp Gly Remacle et al., 2008
Agouti-related protein O00253 21-132 peptide-Arg82+Ser-peptide P Arg Glu Pro Arg Ser Ser Arg Arg Creemers et al., 2006
Alpha-toxin Q8GI68 393-402 Peptide-Arg398+Ser-Peptide S CS Arg Gly Lys Arg Ser Val Asp Ser Remacle et al., 2008
Beta-nerve growth factor P01138 116-125 Peptide-Arg121+Ser-Peptide S CS Arg Ser Lys Arg Ser Ser Ser His Remacle et al., 2008
Beta-secretase 1 P56817 40-49 Peptide-Arg45+Glu-Peptide S CS Arg Leu Pro Arg Glu Thr Asp Glu Remacle et al., 2008
Bone morphogenetic protein 1 P13497 115-124 Peptide-Arg120+Ala-Peptide S CS Arg Ser Arg Arg Ala Ala Thr Ser Remacle et al., 2008
Bone morphogenetic protein 4 P12644 287-296 Peptide-Arg292+Ser-Peptide S CS Arg Ala Lys Arg Ser Pro Lys His Remacle et al., 2008
Brain-derived neurotrophic factor P23560 123-132 Peptide-Arg128+His-Peptide S CS Arg Val Arg Arg His Ser Asp Pro Remacle et al., 2008
cholecystokinin P01355 1-115 peptide-Arg95+Asp-peptide P Ile Ser Asp Arg Asp Tyr Met Gly Wang & Beinfeld, 1997 18706
cholecystokinin P09240 21-115 peptide-Arg45+Ala-peptide P MS Arg Gln Leu Arg Ala Val Leu Arg Pan et al., 2006
cholecystokinin P09240 21-115 peptide-Arg64+Tyr-peptide P MS Leu Leu Ala Arg Tyr Ile Gln Gln Pan et al., 2006
Cholecystokinin precursor P09240 21-115 peptide-Arg70+Lys-peptide P NT Gln Gln Val Arg Lys Ala Pro Ser Rehfeld, 2006
Cholecystokinin precursor P09240 21-115 peptide-Lys81+Asn-peptide P NT Ser Val Leu Lys Asn Leu Gln Ser Rehfeld, 2006
Cholecystokinin precursor P09240 21-115 peptide-Arg106+Ser-peptide P NT Phe Gly Arg Arg Ser Ala Glu Asp Rehfeld, 2006
chromogranin-A P26339 19-463 peptide-Arg357+Trp-peptide P MS Glu Asp Lys Arg Trp Ser Arg Met Pan et al., 2006
chromogranin-A P26339 19-463 peptide-Arg404+Gly-peptide P MS Gln Leu Arg Arg Gly Trp Arg Pro Pan et al., 2006
chromogranin-A P26339 19-463 peptide-Arg373+Leu-peptide P MS Ala Glu Lys Arg Leu Glu Gly Glu Pan et al., 2006
chromogranin-A P26339 19-463 peptide-Arg391+Ala-peptide P MS Phe Arg Thr Arg Ala Tyr Gly Phe Pan et al., 2006
cocaine- and amphetamine-regulated transcript protein P56388 28-129 peptide-Arg59+Ala-peptide P MS Arg Gln Leu Arg Ala Pro Gly Ala Pan et al., 2006
cocaine- and amphetamine-regulated transcript protein P56388 28-129 peptide-Arg81+Ile-peptide P MS Lys Ser Lys Arg Ile Pro Ile Tyr Pan et al., 2006
cocaine- and amphetamine-regulated transcript protein P56388 28-129 peptide-Lys78+Ser-peptide P MS Lys Lys Leu Lys Ser Lys Arg Ile Pan et al., 2006
Cocaine- and amphetamine-regulated transcript protein precursor P49192-1 28-129 peptide-Lys88+Tyr-peptide P Tyr Glu Lys Lys Tyr Gly Gln Val Stein et al., 2006
Cocaine- and amphetamine-regulated transcript protein precursor P49192-2 28-116 peptide-Arg68+Ile-peptide P Lys Ser Lys Arg Ile Pro Ile Tyr Stein et al., 2006
consensus arginyl bond peptide-Lys-Arg+peptide N - NPe Lys Arg CPe - - - Seidah & Chretien, 2004
consensus arginyl bond peptide-Arg-Arg+peptide N - NPe Arg Arg CPe - - - Seidah & Chretien, 2004
consensus arginyl bond peptide-Lys-Xaa-Xaa-Arg+peptide N Lys Xaa Xaa Arg CPe - - - Seidah & Chretien, 2004
consensus arginyl bond peptide-Arg-Xaa-Xaa-Arg+peptide N Arg Xaa Xaa Arg CPe - - - Seidah & Chretien, 2004
consensus arginyl bond peptide-Lys-(Xaa)4-Arg+peptide N Xaa Xaa Xaa Arg CPe - - - Seidah & Chretien, 2004
consensus arginyl bond peptide-Arg-(Xaa)4-Arg+peptide N Xaa Xaa Xaa Arg CPe - - - Seidah & Chretien, 2004
consensus arginyl bond peptide-Lys-(Xaa)6-Arg+peptide N Xaa Xaa Xaa Arg CPe - - - Seidah & Chretien, 2004
consensus arginyl bond peptide-Arg-(Xaa)6-Arg+peptide N Xaa Xaa Xaa Arg CPe - - - Seidah & Chretien, 2004
Cubilin O60494 30-39 Peptide-Arg35+Ser-Peptide S CS Arg Gln Lys Arg Ser Ile Asn Leu Remacle et al., 2008
Diphtheria toxin P00587 214-222 Peptide-Arg218+Ser-Peptide S CS Arg Val Arg Arg Ser Val Gly Ser Remacle et al., 2008
Disintegrin and metalloproteinase domain-containing protein 10 precursor O14672 208-217 Peptide-Arg213+Thr-Peptide S CS Arg Lys Lys Arg Thr Thr Ser Ala Remacle et al., 2008
Disintegrin and metalloproteinase domain-containing protein 17 P78536 209-218 Peptide-Arg214+Arg-Peptide S CS Arg Val Lys Arg Arg Ala Asp Pro Remacle et al., 2008
Disintegrin and metalloproteinase domain-containing protein 19 Q9H013 198-207 Peptide-Arg203+Glu-Peptide S CS Arg Met Lys Arg Glu Asp Leu Asn Remacle et al., 2008
Disintegrin and metalloproteinase domain-containing protein 1a Q60813 215-224 Peptide-Lys220+Pro-Peptide S CS Arg Ser Arg Lys Pro Asp Asp Leu Remacle et al., 2008
Disintegrin and metalloproteinase domain-containing protein 8 P78325 195-204 Peptide-Arg200+Tyr-Peptide S CS Arg Glu Thr Arg Tyr Val Glu Leu Remacle et al., 2008
Ectodysplasin-A Q92838 154-163 Peptide-Arg159+Ser-Peptide S CS Arg Asn Lys Arg Ser Lys Ser Asn Remacle et al., 2008
Envelope glycoprotein Q05320 496-505 Peptide-Arg501+Glu-Peptide S CS Arg Thr Arg Arg Glu Ala Ile Val Remacle et al., 2008
Envelope glycoprotein B P13201 454-464 Peptide-Arg460+Ser-Peptide S CS Arg Thr Lys Arg Ser Thr Asp Gly Remacle et al., 2008
Envelope glycoprotein B P03188 427-436 Peptide-Arg432+Asp-Peptide S CS Arg Arg Arg Arg Asp Ala Gly Asn Remacle et al., 2008
Envelope glycoprotein gp160 Q9WMU9 461-469 Peptide-Arg466+Ala-Peptide S CS Arg Glu Lys Arg Ala Val Gly Leu Remacle et al., 2008
Exotoxin A P11439 299-308 Peptide-Arg304+Gly-Peptide S CS Arg Gln Pro Arg Gly Trp Glu Gln Remacle et al., 2008
Fibrillin-1 P35555 2726-2735 Peptide-Arg2731+Ser-Peptide S CS Arg Lys Arg Arg Ser Thr Asn Glu Remacle et al., 2008
Fibroblast growth factor 23 Q9GZV9 174-183 Peptide-Arg179+Ser-Peptide S CS Arg His Thr Arg Ser Ala Glu Asp Remacle et al., 2008
Furin P09958 70-79 Peptide-Arg75+Ser-Peptide S CS Val Thr Lys Arg Ser Leu Ser Pro Remacle et al., 2008
Furin P09958 102-111 Peptide-Arg107+Asp-Peptide S CS Arg Thr Lys Arg Asp Val Tyr Gln Remacle et al., 2008
Fusion glycoprotein F0 P69353 107-116 Peptide-Arg112+Phe-Peptide S CS Arg His Lys Arg Phe Ala Gly Val Remacle et al., 2008
Fusion glycoprotein F0 Q8V1Q2 111-120 Peptide-Arg116+Leu-Peptide S CS Arg Gln Lys Arg Leu Ile Gly Ala Remacle et al., 2008
Fusion glycoprotein F0 Q84193 104-113 Peptide-Arg109+Phe-Peptide S CS Arg Thr Lys Arg Phe Phe Gly Gly Remacle et al., 2008
gastrin P48757 22-101 peptide-Lys75+Glu-peptide P Leu Ser Lys Lys Gln Arg Pro Arg Rehfeld et al., 2008 21165
Gastrin P01350 53-62 Peptide-Arg58+Gln-Peptide S CS His His Arg Arg Gln Leu Gly Pro Remacle et al., 2008
gastrin precursor P01350 22-101 peptide-Lys75+Gln-peptide P Pro Ser Lys Lys Gln Gly Pro Trp Dickinson et al., 1995 18672
Genome polyprotein P29990 200-209 Peptide-Arg205+Ser-Peptide S CS Arg Gln Lys Arg Ser Val Ala Leu Remacle et al., 2008
Genome polyprotein P06935 210-219 Peptide-Arg215+Ser-Peptide S CS Arg Ser Arg Arg Ser Leu Thr Val Remacle et al., 2008
Glp-Glu-Arg-Thr-Lys-Arg-NHMec Glp-Glu-Arg-Thr-Lys-Arg+NHMec S Arg Thr Lys Arg AMC - - - Seidah & Chretien, 2004
glucagon P01275 21-180 peptide-Arg52+His-peptide P NT Glu Asp Lys Arg His Ser Gln Gly Rouille et al., 1997
glucagon P01275 21-180 peptide-Arg91+His-peptide P NT Ile Ala Lys Arg His Asp Glu Phe Rouille et al., 1997
glucagon P01275 21-180 peptide-Arg83+Asn-peptide P NT Asn Thr Lys Arg Asn Arg Asn Asn Rouille et al., 1997
glucagon precursor P01275 21-178 peptide-Arg63+Asn-peptide P Asn Thr Lys Arg Asn Arg Asn Asn
glucagon precursor P01275 21-178 peptide-Arg52+His-peptide P Glu Asp Lys Arg His Ser Gln Gly
glucagon precursor P29794 21-180 peptide-Arg52+His-peptide N Glu Asp Lys Arg His Ser Gln Gly
glucagon precursor P29794 21-180 peptide-Arg83+Asn-peptide N Asn Thr Lys Arg Asn Lys Asn Asn 17615
glucagon precursor P55095 21-180 peptide-Arg52+His-peptide P Glu Asp Lys Arg His Ser Gln Gly Rothenberg et al., 1995 18648
glucagon precursor P55095 21-180 peptide-Arg83+Asn-peptide P Asn Thr Lys Arg Asn Arg Asn Asn Rouillé et al., 1995 18641
Hemagglutinin O56140 341-350 Peptide-Arg346+Gly-Peptide S CS Arg Lys Lys Arg Gly Leu Phe Gly Remacle et al., 2008
Hepatocyte growth factor receptor P08581 302-311 Peptide-Arg307+Ser-Peptide S CS Arg Lys Lys Arg Ser Thr Lys Lys Remacle et al., 2008
IAPP Q0ZD87 23-89 peptide-Arg33+Lys-peptide P Val Glu Lys Arg Lys Cys Asn Thr Sanke et al., 1988 3401
insulin I P01325 25-108 peptide-Arg87+Gly-peptide P Arg Gln Lys Arg Gly Ile Val Asp Furuta et al., 1998 18650
insulin II P01326 25-110 peptide-Arg89+Gly-peptide P Gln Gln Lys Arg Gly Ile Val Asp Furuta et al., 1998 18651
insulin precursor P01308 25-110 peptide-Arg89+Gly-peptide P Leu Gln Lys Arg Gly Ile Val Glu Seidah & Chretien, 1994 18656
Insulin receptor P06213 757-766 Peptide-Arg762+Ser-Peptide S CS Arg Lys Arg Arg Ser Leu Gly Asp Remacle et al., 2008
insulin-1 P01322 25-110 peptide-Arg56+Glu-peptide P Lys Ser Arg Arg Glu Val Glu Asp Irminger et al., 1997
insulin-1 P01322 25-110 peptide-Arg89+Gly-peptide P Arg Gln Lys Arg Gly Ile Val Asp Irminger et al., 1997
insulin-2 P01323 25-110 peptide-Arg89+Gly-peptide P Arg Gln Lys Arg Gly Ile Val Asp Irminger et al., 1997 18653
insulin-2 P01323 25-110 peptide-Arg56+Glu-peptide P Met Ser Arg Arg Glu Val Glu Asp Irminger et al., 1997
Insulin-like growth factor I P05019 114-123 Peptide-Arg119+Ser-Peptide S CS Lys Ser Ala Arg Ser Val Arg Ala Remacle et al., 2008
Insulin-like growth factor II P01344 87-96 Peptide-Arg92+Asp-Peptide S CS Lys Ser Glu Arg Asp Val Ser Thr Remacle et al., 2008
Integrin alpha-3 P26006 870-879 Peptide-Arg875+Gln-Peptide S CS Arg Arg Arg Arg Gln Leu Asp Pro Remacle et al., 2008
Integrin alpha-4 P13612 586-595 Peptide-Arg591+Ser-Peptide S CS Ile Ser Lys Arg Ser Thr Glu Glu Remacle et al., 2008
Integrin alpha-5 P08648 889-898 Peptide-Arg894+Glu-Peptide S CS Gln Gln Lys Arg Glu Ala Pro Ser Remacle et al., 2008
Integrin alpha-6 P23229 936-945 Peptide-Arg941+Glu-Peptide S CS Arg Lys Lys Arg Glu Ile Thr Glu Remacle et al., 2008
Integrin alpha-7 Q13683 953-962 Peptide-Arg958+Glu-Peptide S CS Arg Arg Arg Arg Glu Leu Glu Pro Remacle et al., 2008
Integrin alpha-V P06756 885-894 Peptide-Arg890+Asp-Peptide S CS Ile Thr Lys Arg Asp Leu Ala Leu Remacle et al., 2008
Interstitial collagenase propeptide P03956 86-95 Peptide-Arg91+Cys-Peptide S CS Lys Gln Pro Arg Cys Gly Val Pro Remacle et al., 2008
Left-right determination factor 2 O00292 72-81 Peptide-Arg77+Phe-Peptide S CS Arg Gly Lys Arg Phe Ser Gln Ser Remacle et al., 2008
Matrix metalloproteinase-14 precursor P50281 106-115 Peptide-Arg111+Tyr-Peptide S CS Arg Arg Lys Arg Tyr Ala Ile Gln Remacle et al., 2008
Matrix metalloproteinase-15 O54732 122-131 Peptide-Arg127+Tyr-Peptide S CS Arg Arg Lys Arg Tyr Thr Leu Thr Remacle et al., 2008
Matrix metalloproteinase-21 Q8N119 139-148 Peptide-Arg144+Ser-Peptide S CS Arg Ser Arg Arg Ser Pro Arg Ala Remacle et al., 2008
Matrix metalloproteinase-24 Q9Y5R2 150-159 Peptide-Arg155+Tyr-Peptide S CS Arg Asn Lys Arg Tyr Ala Leu Thr Remacle et al., 2008
Matrix metalloproteinase-25 Q9NPA2 102-111 Peptide-Arg107+Tyr-Peptide S MS Arg Arg Arg Arg Tyr Ala Leu Ser Remacle et al., 2008
Matrix metalloproteinase-25 Q3U435 157-166 Peptide-Arg162+Tyr-Peptide S MS Arg Arg Arg Arg Tyr Ser Leu Ser Remacle et al., 2008
Meprin A subunit alpha Q16819 648-657 Peptide-Arg653+Ser-Peptide S CS Arg Gln Lys Arg Ser Val Glu Asn Remacle et al., 2008
Natriuretic peptides B P16860 97-106 Peptide-Arg102+Ser-Peptide S CS Arg Ala Pro Arg Ser Pro Lys Met Remacle et al., 2008
neuroendocrine protein 7B2 P05408 27-212 peptide-Lys173+Ser-peptide P Val Ala Lys Lys Ser Val Pro His Zhu et al., 1996 17638
Neuroendocrine protein 7B2 P05408 176-185 Peptide-Arg181+Ser-Peptide S CS Arg Lys Arg Arg Ser Val Asn Pro Remacle et al., 2008
Neurogenic locus notch homolog protein 1 P46531 1659-1668 Peptide-Arg1664+Glu-Peptide S CS Arg Arg Arg Arg Glu Leu Asp Pro Remacle et al., 2008
neuropeptide Y P07808 30-98 peptide-Arg68+Ser-peptide P Tyr Gly Lys Arg Ser Ser Pro Glu Brakch et al., 1998 18708
neurotensin/neuromedin N P20068 23-169 peptide-Arg141+Lys-peptide P Val Ile Lys Arg Lys Ile Pro Tyr Rovère et al., 1996 18674
neurotensin/neuromedin N P20068 23-169 peptide-Arg149+Gln-peptide P Ile Leu Lys Arg Gln Leu Tyr Glu Rovère et al., 1996 18675
neurotensin/neuromedin N P20068 23-169 peptide-Arg164+Ala-peptide P Ile Leu Lys Arg Ala Ser Tyr Tyr Rovère et al., 1996 18677
neurotensin/neuromedin N Q9D3P9 23-169 peptide-Arg141+Lys-peptide P MS Val Ile Lys Arg Lys Ile Pro Tyr Pan et al., 2006
neurotensin/neuromedin N Q9D3P9 23-169 peptide-Arg149+Gln-peptide P MS Ile Leu Lys Arg Gln Leu Tyr Glu Pan et al., 2006
neurotensin/neuromedin N Q9D3P9 23-169 peptide-Arg164+Gly-peptide P MS Ile Leu Lys Arg Gly Ser Tyr Tyr Pan et al., 2006
Neurotrophin-3 P20783 133-142 Peptide-Arg138+Tyr-Peptide S CS Arg Arg Lys Arg Tyr Ala Glu His Remacle et al., 2008
Neurotrophin-4 P34130 75-84 Peptide-Arg80+Gly-Peptide S CS Arg Ser Arg Arg Gly Val Ser Glu Remacle et al., 2008
nociceptin Q64387 20-187 peptide-Arg140+Phe-peptide P MS Leu Gln Lys Arg Phe Gly Gly Phe Pan et al., 2006
nociceptin Q64387 20-187 peptide-Arg159+Phe-peptide P MS Asn Gln Lys Arg Phe Ser Glu Phe Pan et al., 2006
Pancreatic hormone P01298 63-72 Peptide-Arg68+His-Peptide S CS Tyr Gly Lys Arg His Lys Glu Asp Remacle et al., 2008
Parathyroid hormone P01270 26-35 Peptide-Arg31+Ser-Peptide S CS Val Lys Lys Arg Ser Val Ser Glu Remacle et al., 2008
Parathyroid hormone-related protein P12272 31-40 Peptide-Arg36+Ala-Peptide S CS Arg Leu Lys Arg Ala Val Ser Glu Remacle et al., 2008
peptidyl-glycine alpha-amidating monooxygenase P97467 25-979 peptide-Arg34+Phe-peptide P MS Val Phe Lys Arg Phe Lys Glu Thr Pan et al., 2006
Platelet-derived growth factor D Q9GZP0 252-261 Peptide-Lys257+Val-Peptide S CS Arg Lys Ser Lys Val Asp Leu Asp Remacle et al., 2008
Platelet-derived growth factor subunit A P04085 81-90 Peptide-Arg86+Ser-Peptide S CS Arg Arg Lys Arg Ser Ile Glu Glu Remacle et al., 2008
Platelet-derived growth factor subunit B P01127 76-85 Peptide-Arg81+Ser-Peptide S CS Arg Gly Arg Arg Ser Leu Gly Ser Remacle et al., 2008
pro-MCH P56942 22-166 peptide-Arg130+Glu-peptide P MS Gln Glu Lys Arg Glu Ile Gly Asp Pan et al., 2006
pro-MCH P56942 22-166 peptide-Arg146+Asp-peptide P MS Ile Gly Arg Arg Asp Phe Asp Met Pan et al., 2006
pro-melanin-concentrating hormone P14200 22-165 peptide-Arg130+Glu-peptide P Gln Glu Lys Arg Glu Ile Gly Asp Viale et al., 1999 18660
pro-melanin-concentrating hormone P14200 22-165 peptide-Arg146+Asp-peptide P Ile Gly Arg Arg Asp Phe Asp Met Viale et al., 1999
Pro-opiomelanocortin P01189 173-182 Peptide-Arg178+Glu-Peptide S CS Glu Phe Lys Arg Glu Leu Thr Gly Remacle et al., 2008
Pro-opiomelanocortin P01189 150-159 Peptide-Arg155+Pro-Peptide S CS Lys Lys Arg Arg Pro Val Lys Val Remacle et al., 2008
Pro-opiomelanocortin P01189 231-240 Peptide-Arg236+Tyr-Peptide S CS Lys Asp Lys Arg Tyr Gly Gly Phe Remacle et al., 2008
prodynorphin P06300 22-248 peptide-Arg220+Tyr-peptide P Asn Gln Lys Arg Tyr Gly Gly Phe Seidah & Chretien, 1994 18702
prodynorphin P06300 22-248 peptide-Arg201+Tyr-peptide P Leu Tyr Lys Arg Tyr Gly Gly Phe Seidah & Chretien, 1994 18700
prodynorphin P06300 22-248 peptide-Arg165+Tyr-peptide P Gln Ala Lys Arg Tyr Gly Gly Phe Seidah & Chretien, 1994 17616
prodynorphin P06300 22-248 peptide-Arg234+Ser-peptide P Val Val Thr Arg Ser Gln Glu Asn Seidah & Chretien, 1994 17620
prodynorphin P06300 22-248 peptide-Arg176+Ser-peptide P Tyr Pro Lys Arg Ser Ser Glu Met Seidah & Chretien, 1994 17617
prodynorphin P06300 22-248 peptide-Arg210+Pro-peptide P Arg Arg Ile Arg Pro Lys Leu Lys Dupuy et al., 1994 18701
proenkephalin A P04094 25-269 peptide-Arg262+Tyr-peptide P Met Glu Lys Arg Tyr Gly Gly Phe Johanning et al., 1997
proenkephalin A P04094 25-269 peptide-Arg187+Tyr-peptide P Thr Ser Lys Arg Tyr Gly Gly Phe Johanning et al., 1997
proenkephalin-A P01210 25-267 peptide-Arg260+Tyr-peptide P Met Glu Lys Arg Tyr Gly Gly Phe Seidah & Chretien, 1994 17625
proenkephalin-A P01210 25-267 peptide-Arg185+Tyr-peptide P Val Ser Lys Arg Tyr Gly Gly Phe Seidah & Chretien, 1994 18696
proenkephalin-A P01210 25-267 peptide-Arg236+Phe-peptide P Phe Leu Lys Arg Phe Ala Glu Ala Seidah & Chretien, 1994 17624
proenkephalin-A P01210 25-267 peptide-Arg229+Tyr-peptide P Tyr Gln Lys Arg Tyr Gly Gly Phe Seidah & Chretien, 1994 17623
proenkephalin-A P01210 25-267 peptide-Arg195+Ser-peptide P Gly Leu Lys Arg Ser Pro Gln Leu Seidah & Chretien, 1994 17622
proenkephalin-A P22005 25-268 peptide-Arg217+Val-peptide P MS Phe Met Arg Arg Val Gly Arg Pro Pan et al., 2006
proenkephalin-A P22005 25-268 peptide-Arg230+Tyr-peptide P MS Tyr Gln Lys Arg Tyr Gly Gly Phe Pan et al., 2006
proenkephalin-A P22005 25-268 peptide-Arg186+Tyr-peptide P MS Met Ser Lys Arg Tyr Gly Gly Phe Pan et al., 2006
proenkephalin-A P22005 25-268 peptide-Arg196+Ser-peptide P MS Ser Leu Lys Arg Ser Pro Gln Leu Pan et al., 2006
proenkephalin-A P22005 25-268 peptide-Arg261+Tyr-peptide P MS Ile Glu Lys Arg Tyr Gly Gly Phe Pan et al., 2006
proenkephalin-A P22005 25-268 peptide-Ser197+Pro-peptide P MS Leu Lys Arg Ser Pro Gln Leu Glu Pan et al., 2006
proenkephalin-A P22005 25-268 peptide-Arg210+Tyr-peptide P MS Leu Gln Lys Arg Tyr Gly Gly Phe Pan et al., 2006
proenkephalin-A P22005 25-268 peptide-Phe238+Ala-peptide P MS Leu Lys Arg Phe Ala Glu Ser Leu Pan et al., 2006
Proenkephalin-A P01210 137-146 Peptide-Lys142+Asp-Peptide S CS Phe Met Lys Lys Asp Ala Glu Glu Remacle et al., 2008
Proenkephalin-A P01210 190-199 Peptide-Arg195+Ser-Peptide S CS Gly Leu Lys Arg Ser Pro Gln Leu Remacle et al., 2008
proenkephalin-B O35417 22-248 peptide-Arg165+Tyr-peptide P MS Gln Ala Lys Arg Tyr Gly Gly Phe Pan et al., 2006
proenkephalin-B O35417 22-248 peptide-Arg176+Ser-peptide P MS Tyr Pro Lys Arg Ser Ser Glu Met Pan et al., 2006
progonadoliberin-1 P01148 24-92 peptide-Arg36+Asp-peptide P Gly Gly Lys Arg Asp Ala Glu Asn Seidah & Chretien, 1994 17628
Proheparin-binding EGF-like growth factor Q99075 57-66 Peptide-Arg62+Asp-Peptide S CS Arg Lys Val Arg Asp Leu Gln Glu Remacle et al., 2008
Prolow-density lipoprotein receptor-related protein 1 Q07954 3938-3947 Peptide-Arg3943+Gln-Peptide S CS Arg His Arg Arg Gln Ile Asp Arg Remacle et al., 2008
proopiomelanocortin P01193 27-235 peptide-Arg75+Lys-peptide P Glu Asn Pro Arg Lys Tyr Val Met Seidah & Chretien, 1994 17636
proopiomelanocortin P01193 27-235 peptide-Arg123+Ser-peptide P Glu Gly Lys Arg Ser Tyr Ser Met Benjannet et al., 1991 17634
proopiomelanocortin P01193 27-235 peptide-Arg164+Glu-peptide P Glu Phe Lys Arg Glu Leu Glu Gly Benjannet et al., 1991 17632
proopiomelanocortin P01193 27-235 peptide-Arg204+Tyr-peptide P Lys Asp Lys Arg Tyr Gly Gly Phe Benjannet et al., 1991 17633
proopiomelanocortin P01193 27-235 peptide-Arg102+Ala-peptide P Ala Gln Arg Arg Ala Glu Glu Glu Benjannet et al., 1991 18664
proopiomelanocortin P01193 27-235 peptide-Arg140+Arg-peptide P Gly Lys Lys Arg Arg Pro Val Lys Benjannet et al., 1991 17631
proopiomelanocortin P01193 27-235 peptide-Lys233+Gly-Gln P Ala His Lys Lys Gly Gln - - Seidah & Chretien, 1994 17635
proprotein convertase 1 P63239 111-753 peptide-Arg618+Gly-peptide P MS Asn Asp Arg Arg Gly Val Glu Lys Pan et al., 2006
proprotein convertase 1 P63239 111-753 peptide-Arg630+Pro-peptide P MS Val Glu Lys Arg Pro Thr Gln Lys Pan et al., 2006
proprotein convertase subtilisin/kexin type 2 P21661 25-637 peptide-Arg108+Gly-peptide P Arg Lys Lys Arg Gly Tyr Arg Asp Lamango et al., 1999 18723
proSAAS Q9QXV0 34-258 peptide-Arg61+Ala-peptide P MS Arg Leu Arg Arg Ala Val Pro Arg Pan et al., 2006
proSAAS Q9QXV0 34-258 peptide-Arg41+Ser-peptide P MS Lys Glu Pro Arg Ser Leu Ser Ala Pan et al., 2006
proSAAS Q9QXV0 34-258 peptide-Arg242+Leu-peptide P MS Arg Val Lys Arg Leu Glu Asn Pro Pan et al., 2006
proSAAS Q9QXV0 34-258 peptide-Arg58+Leu-peptide P MS Thr Pro Leu Arg Leu Arg Arg Ala Pan et al., 2006
proSAAS Q9QXV0 34-258 peptide-Arg65+Gly-peptide P MS Ala Val Pro Arg Gly Glu Ala Ala Pan et al., 2006
proSAAS Q9QXV0 34-258 peptide-Arg90+Ala-peptide P MS Arg Gln Glu Arg Ala Arg Ala Glu Pan et al., 2006
prosomatostatin P60042 25-116 peptide-Lys102+Ala-peptide P Arg Glu Arg Lys Ala Gly Cys Lys Seidah & Chretien, 1994 18714
protachykinin-1 P41539 20-130 peptide-Arg97+His-peptide P MS Ser His Lys Arg His Lys Thr Asp Pan et al., 2006
protachykinin-1 P41539 20-130 peptide-Arg110+Ala-peptide P MS Met Gly Lys Arg Ala Leu Asn Ser Pan et al., 2006
protachykinin-1 P41539 20-130 peptide-Arg57+Arg-peptide P MS Arg Ile Ala Arg Arg Pro Lys Pro Pan et al., 2006
protachykinin-1 P41539 20-130 peptide-Arg71+Asp-peptide P MS Met Gly Lys Arg Asp Ala Asp Ser Pan et al., 2006
Protective antigen P13423 191-200 Peptide-Arg196+Ser-Peptide S CS Arg Lys Lys Arg Ser Thr Ser Ala Remacle et al., 2008
prothyroliberin P01150 25-255 peptide-Arg52+Phe-peptide P Pro Glu Arg Arg Phe Leu Trp Lys Friedman et al., 1995 18659
secretogranin-1 P16014 21-677 peptide-Arg574+Pro-peptide P Trp Glu Arg Arg Pro Phe Ser Glu Laslop et al., 1998 18717
secretogranin-1 P16014 21-677 peptide-Arg587+Ser-peptide P Tyr Glu Lys Arg Ser Phe Ala Arg Laslop et al., 1998 18718
secretogranin-1 P16014 21-677 peptide-Arg437+Leu-peptide P MS Glu Glu Lys Arg Leu Leu Asp Glu Pan et al., 2006
secretogranin-1 P16014 21-677 peptide-Arg456+Tyr-peptide P MS Thr Ala Lys Arg Tyr Pro Gln Ser Pan et al., 2006
secretogranin-1 P16014 21-677 peptide-Arg591+Ala-peptide P MS Ser Phe Ala Arg Ala Pro Gln Leu Pan et al., 2006
secretogranin-1 P16014 21-677 peptide-Arg515+Leu-peptide P MS Lys Arg Lys Arg Leu Gly Ala Leu Pan et al., 2006
secretogranin-1 P16014 21-677 peptide-Arg537+Gly-peptide P MS Phe Glu Lys Arg Gly Asn Pro Asp Pan et al., 2006
secretogranin-2 Q03517 31-617 peptide-Arg568+Ile-peptide P MS Val Ser Lys Arg Ile Pro Val Gly Pan et al., 2006
secretogranin-2 Q03517 31-617 peptide-Arg612+Ala-peptide P MS Leu Ala Lys Arg Ala Met Glu Asn Pan et al., 2006
secretogranin-2 Q03517 31-617 peptide-Arg183+Thr-peptide P MS Pro Phe Lys Arg Thr Asn Glu Ile Pan et al., 2006
secretogranin-2 Q03517 31-617 peptide-Arg218+Glu-peptide P MS Asn Gln Lys Arg Glu Arg Val Asp Pan et al., 2006
Semaphorin-3A Q14563 550-559 Peptide-Arg555+Gln-Peptide S CS Arg Thr Arg Arg Gln Asp Ile Arg Remacle et al., 2008
Shiga toxin 1 subunit A C8UEJ9 268-277 Peptide-Arg273+Met-Peptide S CS Arg Val Ala Arg Met Ala Ser Asp Remacle et al., 2008
Somatoliberin precursor P16043 20-103 peptide-Arg73+Gln-peptide P Arg Leu Ser Arg Gln Glu Asp Ser Dey et al., 2004
Sortilin-related receptor Q92673 76-85 Peptide-Arg81+Ser-Peptide S CS Arg Arg Lys Arg Ser Ala Ala Leu Remacle et al., 2008
Spike glycoprotein P11223 532-541 Peptide-Arg537+Ser-Peptide S CS Arg Phe Arg Arg Ser Ile Thr Glu Remacle et al., 2008
Stromelysin-3 P24347 92-101 Peptide-Arg97+Phe-Peptide S CS Arg Gln Lys Arg Phe Val Leu Ser Remacle et al., 2008
Structural polyprotein P03316 323-332 Peptide-Arg328+Ser-Peptide S CS Arg Ser Lys Arg Ser Val Ile Asp Remacle et al., 2008
tachykinin-3 P55099 21-116 peptide-Arg81+Asp-peptide P MS Pro Gln Lys Arg Asp Met His Asp Pan et al., 2006
tachykinin-3 P55099 21-116 peptide-Arg94+Asn-peptide P MS Met Gly Lys Arg Asn Ser Gln Pro Pan et al., 2006
Transforming growth factor beta-1 P01137 273-282 Peptide-Arg278+Ala-Peptide S CS Arg His Arg Arg Ala Leu Asp Thr Remacle et al., 2008
Tumor necrosis factor ligand superfamily member 13 O75888 99-100 Peptide-Arg104+Ala-Peptide S CS Arg Lys Arg Arg Ala Val Leu Thr Remacle et al., 2008
Tumor necrosis factor ligand superfamily member 13b Q9Y275 128-137 Peptide-Arg133+Ala-Peptide S CS Arg Asn Lys Arg Ala Val Gln Gly Remacle et al., 2008
Vitamin K-dependent protein C P04070 194-203 Peptide-Arg199+Asp-Peptide S CS His Leu Lys Arg Asp Thr Glu Asp Remacle et al., 2008
von Willebrand factor P04275 758-767 Peptide-Arg763+Ser-Peptide S CS Arg Ser Lys Arg Ser Leu Ser Cys Remacle et al., 2008
Zona pellucida sperm-binding protein 3 P21754 347-356 Peptide-Arg352+His-Peptide S CS Arg Asn Arg Arg His Val Thr Glu Remacle et al., 2008

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