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Literature for peptidase S08.073: PCSK2 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

(Topics flags: S Structure, A Assay, M Mutation, I Inhibitor, P Specificity, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Cendron,L., Rothenberger,S., Cassari,L., Dettin,M. and Pasquato,A.
    Proprotein convertases regulate trafficking and maturation of key proteins within the secretory pathway
    Adv Protein Chem Struct Biol133, 1-54. PubMed  Europe PubMed DOI  V
    2. 2022
  2. Basak,S. and Basak,A.
    Proteins and proteases of Prader-Willi syndrome: a comprehensive review and perspectives
    Biosci Rep42, PubMed  Europe PubMed DOI
  3. Yoon,M.C., Ames,J., Mosier,C., Jiang,Z., Podvin,S., O'Donoghue,A.J. and Hook,V.
    Distinct Dibasic Cleavage Specificities of Neuropeptide-Producing Cathepsin L and Cathepsin V Cysteine Proteases Compared to PC1/3 and PC2 Serine Proteases
    ACS Chem Neurosci13, 245-256. PubMed  Europe PubMed DOI
    4. 2020
  4. Chang,S.Y., DeVera,C., Yang,Z., Yang,T., Song,L., McDowell,A., Xiong,Z.G., Simon,R. and Zhou,A.
    Hippocampal changes in mice lacking an active prohormone convertase 2
    Hippocampus PubMed  Europe PubMed DOI  K
  5. Ramzy,A., Asadi,A. and Kieffer,T.J.
    Revisiting proinsulin processing: evidence that human beta-cells process proinsulin with prohormone convertase (PC) 1/3 but not PC2
    Diabetes PubMed  Europe PubMed DOI
    6. 2016
  6. Maluch,I., Walewska,A., Sikorska,E. and Prahl,A.
    [Proprotein convertases - family of serine proteases with a broad spectrum of physiological functions]
    Postepy Biochem62, 472-481. PubMed  Europe PubMed  V
  7. Ordan,E. and Volk,T.
    Amontillado is required for Drosophila Slit processing and for tendon-mediated muscle patterning
    Biol Open5, 1530-1534. PubMed  Europe PubMed DOI
    8. 2013
  8. Seidah,N.G., Sadr,M.S., Chretien,M. and Mbikay,M.
    The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions
    J Biol Chem288, 21473-21481. PubMed  Europe PubMed DOI  V
  9. Turpeinen,H., Ortutay,Z. and Pesu,M.
    Genetics of the first seven proprotein convertase enzymes in health and disease
    Curr Genomics14, 453-467. PubMed  Europe PubMed DOI  V
  10. Vivoli,M. and Lindberg,I.
    Prohormone convertase 2
    2, 1797-1802. DOI  V
    11. 2012
  11. Cyr,N.E., Stuart,R.C., Zhu,X., Steiner,D.F. and Nillni,E.A.
    Biosynthesis of proTRH-derived peptides in prohormone convertase 1 and 2 knockout mice
    Peptides35, 42-48. PubMed  Europe PubMed DOI  K
  12. Seidah,N.G. and Prat,A.
    The biology and therapeutic targeting of the proprotein convertases
    Nat Rev Drug Discov11, 367-383. PubMed  Europe PubMed DOI  V
  13. Seidah,N.G.
    Proprotein convertase 2
    [ISSN:978-0-12-407742-3]3, 3290-3295. DOI
    14. 2011
  14. Basak,A., Chen,A., Majumdar,S. and Smith,H.P.
    In vitro assay for protease activity of proprotein convertase subtilisin kexins (PCSKs): an overall review of existing and new methodologies
    Methods Mol Biol768, 127-153. PubMed  Europe PubMed DOI  A
  15. Gagnon,J., Mayne,J., Chen,A., Raymond,A., Woulfe,J., Mbikay,M. and Chretien,M.
    PCSK2-null mice exhibit delayed intestinal motility, reduced refeeding response and altered plasma levels of several regulatory peptides
    Life Sci88, 212-217. PubMed  Europe PubMed DOI  K
  16. Helwig,M., Lee,S.N., Hwang,J.R., Ozawa,A., Medrano,J.F. and Lindberg,I.
    Dynamic modulation of prohormone convertase 2 (PC2)-mediated precursor processing by 7B2 protein: preferential effect on glucagon synthesis
    J Biol Chem286, 42504-42513. PubMed  Europe PubMed DOI
  17. Seidah,N.G.
    The proprotein convertases, 20 years later
    Methods Mol Biol768, 23-57. PubMed  Europe PubMed DOI  V
  18. Seidah,N.G.
    What lies ahead for the proprotein convertases?
    Ann N Y Acad Sci1220, 149-161. PubMed  Europe PubMed DOI  V
  19. Wegener,C., Herbert,H., Kahnt,J., Bender,M. and Rhea,J.M.
    Deficiency of prohormone convertase dPC2 (AMONTILLADO) results in impaired production of bioactive neuropeptide hormones in Drosophila
    J Neurochem118, 581-595. PubMed  Europe PubMed DOI
    20. 2010
  20. Anini,Y., Mayne,J., Gagnon,J., Sherbafi,J., Chen,A., Kaefer,N., Chretien,M. and Mbikay,M.
    Genetic deficiency for proprotein convertase subtilisin/kexin type 2 in mice is associated with decreased adiposity and protection from dietary fat-induced body weight gain
    Int J Obes (Lond)34, 1599-1607. PubMed  Europe PubMed DOI  K
  21. Rhea,J.M., Wegener,C. and Bender,M.
    The proprotein convertase encoded by amontillado (amon) is required in Drosophila corpora cardiaca endocrine cells producing the glucose regulatory hormone AKH
    PLoS Genet6, e1000967-e1000967. PubMed  Europe PubMed DOI
  22. Tian,S. and Jianhua,W.
    Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors
    Int J Biol Sci6, 89-95. PubMed  Europe PubMed  P  I
  23. Zhang,X., Pan,H., Peng,B., Steiner,D.F., Pintar,J.E. and Fricker,L.D.
    Neuropeptidomic analysis establishes a major role for prohormone convertase-2 in neuropeptide biosynthesis
    J Neurochem112, 1168-1179. PubMed  Europe PubMed DOI
    24. 2009
  24. Aparoy,P., Chatterjee,M., Guruprasad,L. and Reddanna,P.
    Structure prediction of neuroendocrine convertase-2: a potential target in various cancers
    Protein Pept Lett16, 383-391. PubMed  Europe PubMed DOI  S
  25. Cummins,S.F., York,P.S., Hanna,P.H., Degnan,B.M. and Croll,R.P.
    Expression of prohormone convertase 2 and the generation of neuropeptides in the developing nervous system of the gastropod Haliotis
    Int J Dev Biol53, 1081-1088. PubMed  Europe PubMed DOI
  26. Kowalska,D., Liu,J., Appel,J.R., Ozawa,A., Nefzi,A., Mackin,R.B., Houghten,R.A. and Lindberg,I.
    Synthetic small-molecule prohormone convertase 2 inhibitors
    Mol Pharmacol75, 617-625. PubMed  Europe PubMed DOI  I
  27. Morash,M.G., MacDonald,A.B., Croll,R.P. and Anini,Y.
    Molecular cloning, ontogeny and tissue distribution of zebrafish (Danio rerio) prohormone convertases: pcsk1 and pcsk2
    Gen Comp Endocrinol162, 179-187. PubMed  Europe PubMed DOI
  28. Rayburn,L.Y., Rhea,J., Jocoy,S.R. and Bender,M.
    The proprotein convertase amontillado (amon) is required during Drosophila pupal development
    Dev Biol333, 48-56. PubMed  Europe PubMed DOI
  29. Rholam,M. and Fahy,C.
    Processing of peptide and hormone precursors at the dibasic cleavage sites
    Cell Mol Life Sci66, 2075-2091. PubMed  Europe PubMed DOI
    30. 2008
  30. Creemers,J.W. and Khatib,A.M.
    Knock-out mouse models of proprotein convertases: unique functions or redundancy?
    Front Biosci13, 4960-4971. PubMed  Europe PubMed DOI  K
  31. Lee,S.N. and Lindberg,I.
    7B2 prevents unfolding and aggregation of prohormone convertase 2
    Endocrinology149, 4116-4127. PubMed  Europe PubMed DOI
  32. Rehfeld,J.F., Zhu,X., Norrbom,C., Bundgaard,J.R., Johnsen,A.H., Nielsen,J.E., Vikesaa,J., Stein,J., Dey,A., Steiner,D.F. and Friis-Hansen,L.
    Prohormone convertases 1/3 and 2 together orchestrate the site-specific cleavages of progastrin to release gastrin-34 and gastrin-17
    Biochem J415, 35-43. PubMed  Europe PubMed DOI
  33. Remacle,A.G., Shiryaev,S.A., Oh,E.S., Cieplak,P., Srinivasan,A., Wei,G., Liddington,R.C., Ratnikov,B.I., Parent,A., Desjardins,R., Day,R., Smith,J.W., Lebl,M. and Strongin,A.Y.
    Substrate cleavage analysis of furin and related proprotein convertases. A comparative study
    J Biol Chem283, 20897-20906. PubMed  Europe PubMed DOI  P
    34. 2007
  34. Dikeakos,J.D., Mercure,C., Lacombe,M.J., Seidah,N.G. and Reudelhuber,T.L.
    PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism
    FEBS J274, 4094-4102. PubMed  Europe PubMed DOI
  35. Leak,T.S., Keene,K.L., Langefeld,C.D., Gallagher,C.J., Mychaleckyj,J.C., Freedman,B.I., Bowden,D.W., Rich,S.S. and Sale,M.M.
    Association of the proprotein convertase subtilisin/kexin-type 2 (PCSK2) gene with type 2 diabetes in an African American population
    Mol Genet Metab92, 145-150. PubMed  Europe PubMed DOI  M
    36. 2006
  36. [YEAR:2-10-2006]Croissandeau,G., Wahnon,F., Yashpal,K., Seidah,N.G., Coderre,T.J., Chretien,M. and Mbikay,M.
    Increased stress-induced analgesia in mice lacking the proneuropeptide convertase PC2
    Neurosci Lett406, 71-75. PubMed  Europe PubMed DOI  K
  37. Marzban,L., Rhodes,C.J., Steiner,D.F., Haataja,L., Halban,P.A. and Verchere,C.B.
    Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death
    Diabetes55, 2192-2201. PubMed  Europe PubMed DOI
  38. [YEAR:11-8-2006]Pan,H., Che,F.Y., Peng,B., Steiner,D.F., Pintar,J.E. and Fricker,L.D.
    The role of prohormone convertase-2 in hypothalamic neuropeptide processing: a quantitative neuropeptidomic study
    J Neurochem98, 1763-1777. PubMed  Europe PubMed DOI
  39. Scamuffa,N., Calvo,F., Chretien,M., Seidah,N.G. and Khatib,A.M.
    Proprotein convertases: lessons from knockouts
    FASEB J20, 1954-1963. PubMed  Europe PubMed DOI  K  V
    40. 2005
  40. [YEAR:14-1-2005]Henrich,S., Lindberg,I., Bode,W. and Than,M.E.
    Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity
    J Mol Biol345, 211-227. PubMed  Europe PubMed DOI  S
  41. [YEAR:23-6-2005]Tagen,M.B. and Beinfeld,M.C.
    Recombinant prohormone convertase 1 and 2 cleave purified pro cholecystokinin (CCK) and a synthetic peptide containing CCK 8 Gly Arg Arg and the carboxyl-terminal flanking peptide
    Peptides26, 2530-2535. PubMed  Europe PubMed DOI
    42. 2004
  42. [YEAR:23-10-2004]Laurent,V., Jaubert-Miazza,L., Desjardins,R., Day,R. and Lindberg,I.
    Biosynthesis of proopiomelanocortin-derived peptides in prohormone convertase 2 and 7B2 null mice
    Endocrinology145, 519-528. PubMed  Europe PubMed DOI
  43. [YEAR:4-8-2004]Ogiwara,K., Shinohara,M. and Takahashi,T.
    Expression of proprotein convertase 2 mRNA in the ovarian follicles of the medaka, Oryzias latipes
    Gene337, 79-89. PubMed  Europe PubMed DOI
  44. Seidah,N.G. and Chretien,M.
    Proprotein convertase 2
    [ISSN:0-12-079610-4]2, 1865-1868.  V
  45. [YEAR:28-5-2004]Webb,G.C., Dey,A., Wang,J., Stein,J., Milewski,M. and Steiner,D.F.
    Altered proglucagon processing in an alpha-cell line derived from prohormone convertase 2 null mouse islets
    J Biol Chem279, 31068-31075. PubMed  Europe PubMed DOI
    46. 2003
  46. Cornwall,G.A., Cameron,A., Lindberg,I., Hardy,D.M., Cormier,N. and Hsia,N.
    The cystatin-related epididymal spermatogenic protein inhibits the serine protease prohormone convertase 2
    Endocrinology144, 901-908. PubMed  Europe PubMed DOI
  47. [YEAR:28-3-2003]Doblinger,A., Becker,A., Seidah,N.G. and Laslop,A.
    Proteolytic processing of chromogranin A by the prohormone convertase PC2
    Regul Pept111, 111-116. PubMed  Europe PubMed DOI
  48. [YEAR:28-2-2003]Li,Q.L., Naqvi,S., Shen,X., Liu,Y.J., Lindberg,I. and Friedman,T.C.
    Prohormone convertase 2 enzymatic activity and its regulation in neuro-endocrine cells and tissues
    Regul Pept110, 197-205. PubMed  Europe PubMed DOI
  49. Miller,R., Aaron,W., Toneff,T., Vishnuvardhan,D., Beinfeld,M.C. and Hook,V.Y.
    Obliteration of alpha-melanocyte-stimulating hormone derived from POMC in pituitary and brains of PC2-deficient mice
    J Neurochem86, 556-563. PubMed  Europe PubMed DOI  K
  50. Peinado,J.R., Li,H., Johanning,K. and Lindberg,I.
    Cleavage of recombinant proenkephalin and blockade mutants by prohormone convertases 1 and 2: an in vitro specificity study
    J Neurochem87, 868-878. PubMed  Europe PubMed DOI
  51. Rayburn,L.Y., Gooding,H.C., Choksi,S.P., Maloney,D., Kidd,A.R., III, Siekhaus,D.E. and Bender,M.
    amontillado, the Drosophila homolog of the prohormone processing protease PC2, is required during embryogenesis and early larval development
    Genetics163, 227-237. PubMed  Europe PubMed
  52. Taylor,N.A., Van de Ven,W.J. and Creemers,J.W.
    Curbing activation: proprotein convertases in homeostasis and pathology
    FASEB J17, 1215-1227. PubMed  Europe PubMed DOI  K
  53. Vincent,M., Guz,Y., Rozenberg,M., Webb,G., Furuta,M., Steiner,D. and Teitelman,G.
    Abrogation of protein convertase 2 activity results in delayed islet cell differentiation and maturation, increased alpha-cell proliferation, and islet neogenesis
    Endocrinology144, 4061-4069. PubMed  Europe PubMed DOI  K
  54. Winsky-Sommerer,R., Grouselle,D., Rougeot,C., Laurent,V., David,J.P., Delacourte,A., Dournaud,P., Seidah,N.G., Lindberg,I., Trottier,S. and Epelbaum,J.
    The proprotein convertase PC2 is involved in the maturation of prosomatostatin to somatostatin-14 but not in the somatostatin deficit in Alzheimer's disease
    Neuroscience122, 437-447. PubMed  Europe PubMed DOI
    55. 2002
  55. Fugere,M. and Day,R.
    Inhibitors of the subtilase-like pro-protein convertases (SPCs)
    Curr Pharm Des8, 549-562. PubMed  Europe PubMed DOI  V  I
  56. Kovaleva,E.S., Yakovlev,A.G., Masler,E.P. and Chitwood,D.J.
    Human proprotein convertase 2 homologue from a plant nematode: Cloning, characterization, and comparison with other species
    FASEB J16, 1099-1101. PubMed  Europe PubMed DOI
  57. [YEAR:5-3-2002]Laurent,V., Kimble,A., Peng,B., Zhu,P., Pintar,J.E., Steiner,D.F. and Lindberg,I.
    Mortality in 7B2 null mice can be rescued by adrenalectomy: involvement of dopamine in ACTH hypersecretion
    Proc Natl Acad Sci U S A99, 3087-3092. PubMed  Europe PubMed DOI
  58. Seidah,N.G. and Prat,A.
    Precursor convertases in the secretory pathway, cytosol and extracellular milieu
    Essays Biochem38, 79-94. PubMed  Europe PubMed
  59. Villeneuve,P., Feliciangeli,S., Croissandeau,G., Seidah,N.G., Mbikay,M., Kitabgi,P. and Beaudet,A.
    Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study
    J Neurochem82, 783-793. PubMed  Europe PubMed DOI  K
    60. 2001
  60. [YEAR:20-7-2001]Furuta,M., Zhou,A., Webb,G., Carroll,R., Ravazzola,M., Orci,L. and Steiner,D.F.
    Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice
    J Biol Chem276, 27197-27202. PubMed  Europe PubMed DOI  K
  61. Wang,J., Xu,J., Finnerty,J., Furuta,M., Steiner,D.F. and Verchere,C.B.
    The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site
    Diabetes50, 534-539. PubMed  Europe PubMed
    62. 2000
  62. Berman,Y., Mzhavia,N., Polonskaia,A., Furuta,M., Steiner,D.F., Pintar,J.E. and Devi,L.A.
    Defective prodynorphin processing in mice lacking prohormone convertase PC2
    J Neurochem75, 1763-1770. PubMed  Europe PubMed DOI  K
  63. Brakch,N., Rholam,M., Simonetti,M. and Cohen,P.
    Favourable side-chain orientation of cleavage site dibasic residues of prohormone in proteolytic processing by prohormone convertase 1/3
    Eur J Biochem267, 1626-1633. PubMed  Europe PubMed DOI
  64. [YEAR:9-6-2000]Hwang,J.R., Siekhaus,D.E., Fuller,R.S., Taghert,P.H. and Lindberg,I.
    Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2. Insect cell-specific processing and secretion
    J Biol Chem275, 17886-17893. PubMed  Europe PubMed DOI
  65. Hwang,S.R., Ng,S.M., Steineckert,B., Seidah,N.G. and Hook,V.Y.H.
    Molecular cloning demonstrates structural features of homologous bovine prohormone convertases 1 and 2
    DNA Cell Biol19, 409-419. PubMed  Europe PubMed DOI
  66. [YEAR:15-12-2000]Muller,L., Cameron,A., Fortenberry,Y., Apletalina,E.V. and Lindberg,I.
    Processing and sorting of the prohormone convertase 2 propeptide
    J Biol Chem275, 39213-39222. PubMed  Europe PubMed DOI
  67. [YEAR:28-8-2000]Villeneuve,P., Lafortune,L., Seidah,N.G., Kitabgi,P. and Beaudet,A.
    Immunohistochemical evidence for the involvement of protein convertases 5A and 2 in the processing of pro-neurotensin in rat brain
    J Comp Neurol424, 461-475. PubMed  Europe PubMed DOI
  68. [YEAR:28-8-2000]Winsky-Sommerer,R., Benjannet,S., Rovere,C., Barbero,P., Seidah,N.G., Epelbaum,J. and Dournaud,P.
    Regional and cellular localization of the neuroendocrine prohormone convertases PC1 and PC2 in the rat central nervous system
    J Comp Neurol424, 439-460. PubMed  Europe PubMed
    69. 1999
  69. Fortenberry,Y., Liu,J. and Lindberg,I.
    The role of the 7B2 CT peptide in the inhibition of prohormone convertase 2 in endocrine cell lines
    J Neurochem73, 994-1003. PubMed  Europe PubMed DOI
  70. Lamango,N.S., Apletalina,E., Liu,J. and Lindberg,I.
    The proteolytic maturation of prohormone convertase 2 (PC2) is a pH-driven process
    Arch Biochem Biophys362, 275-282. PubMed  Europe PubMed DOI
  71. [YEAR:23-7-1999]Muller,L., Zhu,P., Juliano,M.A., Juliano,L. and Lindberg,I.
    A 36-residue peptide contains all of the information required for 7B2-mediated activation of prohormone convertase 2
    J Biol Chem274, 21471-21477. PubMed  Europe PubMed DOI
  72. Muller,L. and Lindberg,I.
    The cell biology of the prohormone convertases PC1 and PC2
    Prog Nucleic Acid Res Mol Biol63, 69-108. PubMed  Europe PubMed
  73. Seidah,N.G., Benjannet,S., Hamelin,J., Mamarbachi,A.M., Basak,A., Marcinkiewicz,J., Mbikay,M., Chretien,M. and Marcinkiewicz,M.
    The subtilisin/kexin family of precursor convertases. Emphasis on PC1, PC2/7B2, POMC and the novel enzyme SKI-1
    Ann N Y Acad Sci885, 57-74. PubMed  Europe PubMed
  74. [YEAR:15-8-1999]Siekhaus,D.E. and Fuller,R.S.
    A role for amontillado, the Drosophila homolog of the neuropeptide precursor processing protease PC2, in triggering hatching behavior
    J Neurosci19, 6942-6954. PubMed  Europe PubMed
    75. 1998
  75. [YEAR:22-5-1998]Benjannet,S., Mamarbachi,A.M., Hamelin,J., Savaria,D., Munzer,J.S., Chretien,M. and Seidah,N.G.
    Residues unique to the pro-hormone convertase PC2 modulate its autoactivation, binding to 7B2 and enzymatic activity
    FEBS Lett428, 37-42. PubMed  Europe PubMed DOI
  76. [YEAR:9-1-1998]Day,R., Lazure,C., Basak,A., Boudreault,A., Limperis,P., Dong,W. and Lindberg,I.
    Prodynorphin processing by proprotein convertase 2. Cleavage at single basic residues and enhanced processing in the presence of carboxypeptidase activity
    J Biol Chem273, 829-836. PubMed  Europe PubMed DOI  I
  77. [YEAR:15-9-1998]Scougall,K., Taylor,N.A., Jermany,J.L., Docherty,K. and Shennan,K.I.
    Differences in the autocatalytic cleavage of pro-PC2 and pro-PC3 can be attributed to sequences within the propeptide and Asp310 of pro-PC2
    Biochem J334, 531-537. PubMed  Europe PubMed
  78. [YEAR:13-2-1998]Van Horssen,A.M. and Martens,G.J.
    Mapping of the domain in the neuroendocrine protein 7B2 important for its helper function towards prohormone convertase PC2
    Mol Cell Endocrinol137, 7-12. PubMed  Europe PubMed DOI
    79. 1997
  79. [YEAR:24-6-1997]Furuta,M., Yano,H., Zhou,A., Rouille,Y., Holst,J.J., Carroll,R., Ravazzola,M., Orci,L., Furuta,H. and Steiner,D.F.
    Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2
    Proc Natl Acad Sci U S A94, 6646-6651. PubMed  Europe PubMed DOI  K
  80. Rouille,Y., Bianchi,M., Irminger,J.C. and Halban,P.A.
    Role of the prohormone convertase PC2 in the processing of proglucagon to glucagon
    FEBS Lett413, 119-123. PubMed  Europe PubMed
  81. Urbe,S., Dittie,A.S. and Tooze,S.A.
    pH-dependent processing of secretogranin II by the endopeptidase PC2 in isolated immature secretory granules
    Biochem J321, 65-74. PubMed  Europe PubMed
    82. 1996
  82. Johanning,K., Mathis,J.P. and Lindberg,I.
    Role of PC2 in proenkephalin processing: antisense and overexpression studies
    J Neurochem66, 898-907. PubMed  Europe PubMed
  83. Lamango,N.S., Zhu,X. and Lindberg,I.
    Purification and enzymatic characterization of recombinant prohormone convertase 2: Stabilization of activity by 21 kDa 7B2
    Arch Biochem Biophys330, 238-250. PubMed  Europe PubMed DOI
  84. Paquet,L., Zhou,A., Chang,E.Y. and Mains,R.E.
    Peptide biosynthetic processing: Distinguishing prohormone convertases PC1 and PC2
    Mol Cell Endocrinol120, 161-168. PubMed  Europe PubMed DOI
  85. Rovere,C., Barbero,P. and Kitabgi,P.
    Evidence that PC2 is the endogenous pro-neurotensin convertase in rMTC 6-23 cells and that PC1- and PC2-transfected PC12 cells differentially process pro-neurotensin
    J Biol Chem271, 11368-11375. PubMed  Europe PubMed
  86. [YEAR:14-5-1996]Zhu,X., Rouille,Y., Lamango,N.S., Steiner,D.F. and Lindberg,I.
    Internal cleavage of the inhibitory 7B2 carboxyl-terminal peptide by PC2: a potential mechanism for its inactivation
    Proc Natl Acad Sci U S A93, 4919-4924. PubMed  Europe PubMed DOI
  87. Zhu,X., Lamango,N.S. and Lindberg,I.
    Involvement of a polyproline helix-like structure in the interaction of 7B2 with prohormone convertase 2
    J Biol Chem271, 23582-23587. PubMed  Europe PubMed DOI
    88. 1995
  88. Benjannet,S., Lusson,J., Hamelin,J., Savaria,D., Chretien,M. and Seidah,N.G.
    Structure-function studies on the biosynthesis and bioactivity of the precursor convertase PC2 and the formation of the PC2/7B2 complex
    FEBS Lett362, 151-155. PubMed  Europe PubMed DOI
  89. Benjannet,S., Savaria,D., Chretien,M. and Seidah,N.G.
    7B2 is a specific intracellular binding protein of the prohormone convertase PC2
    J Neurochem64, 2303-2311. PubMed  Europe PubMed
  90. Brakch,N., Galanopoulou,A.S., Patel,Y.C., Boileau,G. and Seidah,N.G.
    Comparative proteolytic processing of rat prosomatostatin by the convertases PC1, PC2, furin, PACE4 and PC5 in constitutive and regulated secretory pathways
    FEBS Lett362, 143-146. PubMed  Europe PubMed DOI
  91. Braks,J.A. and Martens,G.J.
    The neuroendocrine chaperone 7B2 can enhance in vitro POMC cleavage by prohormone convertase PC2
    FEBS Lett371, 154-158. PubMed  Europe PubMed DOI
  92. Chaudhuri,B. and Stephan,C.
    A C-terminal domain, which prevents secretion of the neuroendocrine protein 7B2 in Saccharomyces cerevisiae, inhibits Kex2 yet is processed by the Yap3 protease
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