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Literature for peptidase S08.073: PCSK2 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

(Topics flags: S Structure, A Assay, M Mutation, I Inhibitor, P Specificity, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Cendron,L., Rothenberger,S., Cassari,L., Dettin,M. and Pasquato,A.<br>Proprotein convertases regulate trafficking and maturation of key proteins within the secretory pathway<br>Adv Protein Chem Struct Biol (2023) 133, 1-54. PubMed  Europe PubMed DOI  V
    2. 2022
  2. Basak,S. and Basak,A.<br>Proteins and proteases of Prader-Willi syndrome: a comprehensive review and perspectives<br>Biosci Rep (2022) 42 PubMed  Europe PubMed DOI  PMC  EPMC
  3. Yoon,M.C., Ames,J., Mosier,C., Jiang,Z., Podvin,S., O'Donoghue,A.J. and Hook,V.<br>Distinct Dibasic Cleavage Specificities of Neuropeptide-Producing Cathepsin L and Cathepsin V Cysteine Proteases Compared to PC1/3 and PC2 Serine Proteases<br>ACS Chem Neurosci (2022) 13, 245-256. PubMed  Europe PubMed DOI
    4. 2020
  4. Chang,S.Y., DeVera,C., Yang,Z., Yang,T., Song,L., McDowell,A., Xiong,Z.G., Simon,R. and Zhou,A.<br>Hippocampal changes in mice lacking an active prohormone convertase 2<br>Hippocampus (2020) PubMed  Europe PubMed DOI  K
  5. Ramzy,A., Asadi,A. and Kieffer,T.J.<br>Revisiting proinsulin processing: evidence that human beta-cells process proinsulin with prohormone convertase (PC) 1/3 but not PC2<br>Diabetes (2020) PubMed  Europe PubMed DOI
    6. 2016
  6. Maluch,I., Walewska,A., Sikorska,E. and Prahl,A.<br>[Proprotein convertases - family of serine proteases with a broad spectrum of physiological functions]<br>Postepy Biochem (2016) 62, 472-481. PubMed  Europe PubMed  V
  7. Ordan,E. and Volk,T.<br>Amontillado is required for Drosophila Slit processing and for tendon-mediated muscle patterning<br>Biol Open (2016) 5, 1530-1534. PubMed  Europe PubMed DOI
    8. 2013
  8. Seidah,N.G., Sadr,M.S., Chretien,M. and Mbikay,M.<br>The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions<br>J Biol Chem (2013) 288, 21473-21481. PubMed  Europe PubMed DOI  V
  9. Turpeinen,H., Ortutay,Z. and Pesu,M.<br>Genetics of the first seven proprotein convertase enzymes in health and disease<br>Curr Genomics (2013) 14, 453-467. PubMed  Europe PubMed DOI  PMC  EPMC  V
  10. Vivoli,M. and Lindberg,I.<br>Prohormone convertase 2<br> (2013) 2, 1797-1802. DOI  V
    11. 2012
  11. Cyr,N.E., Stuart,R.C., Zhu,X., Steiner,D.F. and Nillni,E.A.<br>Biosynthesis of proTRH-derived peptides in prohormone convertase 1 and 2 knockout mice<br>Peptides (2012) 35, 42-48. PubMed  Europe PubMed DOI  K
  12. Seidah,N.G. and Prat,A.<br>The biology and therapeutic targeting of the proprotein convertases<br>Nat Rev Drug Discov (2012) 11, 367-383. PubMed  Europe PubMed DOI  V
  13. Seidah,N.G.<br>Proprotein convertase 2<br>[ISSN:978-0-12-407742-3] (2012) 3, 3290-3295. DOI
    14. 2011
  14. Basak,A., Chen,A., Majumdar,S. and Smith,H.P.<br>In vitro assay for protease activity of proprotein convertase subtilisin kexins (PCSKs): an overall review of existing and new methodologies<br>Methods Mol Biol (2011) 768, 127-153. PubMed  Europe PubMed DOI  A
  15. Gagnon,J., Mayne,J., Chen,A., Raymond,A., Woulfe,J., Mbikay,M. and Chretien,M.<br>PCSK2-null mice exhibit delayed intestinal motility, reduced refeeding response and altered plasma levels of several regulatory peptides<br>Life Sci (2011) 88, 212-217. PubMed  Europe PubMed DOI  K
  16. Helwig,M., Lee,S.N., Hwang,J.R., Ozawa,A., Medrano,J.F. and Lindberg,I.<br>Dynamic modulation of prohormone convertase 2 (PC2)-mediated precursor processing by 7B2 protein: preferential effect on glucagon synthesis<br>J Biol Chem (2011) 286, 42504-42513. PubMed  Europe PubMed DOI
  17. Seidah,N.G.<br>What lies ahead for the proprotein convertases?<br>Ann N Y Acad Sci (2011) 1220, 149-161. PubMed  Europe PubMed DOI  V
  18. Seidah,N.G.<br>The proprotein convertases, 20 years later<br>Methods Mol Biol (2011) 768, 23-57. PubMed  Europe PubMed DOI  V
  19. Wegener,C., Herbert,H., Kahnt,J., Bender,M. and Rhea,J.M.<br>Deficiency of prohormone convertase dPC2 (AMONTILLADO) results in impaired production of bioactive neuropeptide hormones in Drosophila<br>J Neurochem (2011) 118, 581-595. PubMed  Europe PubMed DOI
    20. 2010
  20. Anini,Y., Mayne,J., Gagnon,J., Sherbafi,J., Chen,A., Kaefer,N., Chretien,M. and Mbikay,M.<br>Genetic deficiency for proprotein convertase subtilisin/kexin type 2 in mice is associated with decreased adiposity and protection from dietary fat-induced body weight gain<br>Int J Obes (Lond) (2010) 34, 1599-1607. PubMed  Europe PubMed DOI  K
  21. Rhea,J.M., Wegener,C. and Bender,M.<br>The proprotein convertase encoded by amontillado (amon) is required in Drosophila corpora cardiaca endocrine cells producing the glucose regulatory hormone AKH<br>PLoS Genet (2010) 6, e1000967-e1000967. PubMed  Europe PubMed DOI
  22. Tian,S. and Jianhua,W.<br>Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors<br>Int J Biol Sci (2010) 6, 89-95. PubMed  Europe PubMed  PMC  EPMC  P  I
  23. Zhang,X., Pan,H., Peng,B., Steiner,D.F., Pintar,J.E. and Fricker,L.D.<br>Neuropeptidomic analysis establishes a major role for prohormone convertase-2 in neuropeptide biosynthesis<br>J Neurochem (2010) 112, 1168-1179. PubMed  Europe PubMed DOI
    24. 2009
  24. Aparoy,P., Chatterjee,M., Guruprasad,L. and Reddanna,P.<br>Structure prediction of neuroendocrine convertase-2: a potential target in various cancers<br>Protein Pept Lett (2009) 16, 383-391. PubMed  Europe PubMed DOI  S
  25. Cummins,S.F., York,P.S., Hanna,P.H., Degnan,B.M. and Croll,R.P.<br>Expression of prohormone convertase 2 and the generation of neuropeptides in the developing nervous system of the gastropod Haliotis<br>Int J Dev Biol (2009) 53, 1081-1088. PubMed  Europe PubMed DOI
  26. Kowalska,D., Liu,J., Appel,J.R., Ozawa,A., Nefzi,A., Mackin,R.B., Houghten,R.A. and Lindberg,I.<br>Synthetic small-molecule prohormone convertase 2 inhibitors<br>Mol Pharmacol (2009) 75, 617-625. PubMed  Europe PubMed DOI  PMC  EPMC  I
  27. Morash,M.G., MacDonald,A.B., Croll,R.P. and Anini,Y.<br>Molecular cloning, ontogeny and tissue distribution of zebrafish (Danio rerio) prohormone convertases: pcsk1 and pcsk2<br>Gen Comp Endocrinol (2009) 162, 179-187. PubMed  Europe PubMed DOI
  28. Rayburn,L.Y., Rhea,J., Jocoy,S.R. and Bender,M.<br>The proprotein convertase amontillado (amon) is required during Drosophila pupal development<br>Dev Biol (2009) 333, 48-56. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Rholam,M. and Fahy,C.<br>Processing of peptide and hormone precursors at the dibasic cleavage sites<br>Cell Mol Life Sci (2009) 66, 2075-2091. PubMed  Europe PubMed DOI
    30. 2008
  30. Creemers,J.W. and Khatib,A.M.<br>Knock-out mouse models of proprotein convertases: unique functions or redundancy?<br>Front Biosci (2008) 13, 4960-4971. PubMed  Europe PubMed DOI  K
  31. Lee,S.N. and Lindberg,I.<br>7B2 prevents unfolding and aggregation of prohormone convertase 2<br>Endocrinology (2008) 149, 4116-4127. PubMed  Europe PubMed DOI  PMC  EPMC
  32. Rehfeld,J.F., Zhu,X., Norrbom,C., Bundgaard,J.R., Johnsen,A.H., Nielsen,J.E., Vikesaa,J., Stein,J., Dey,A., Steiner,D.F. and Friis-Hansen,L.<br>Prohormone convertases 1/3 and 2 together orchestrate the site-specific cleavages of progastrin to release gastrin-34 and gastrin-17<br>Biochem J (2008) 415, 35-43. PubMed  Europe PubMed DOI
  33. Remacle,A.G., Shiryaev,S.A., Oh,E.S., Cieplak,P., Srinivasan,A., Wei,G., Liddington,R.C., Ratnikov,B.I., Parent,A., Desjardins,R., Day,R., Smith,J.W., Lebl,M. and Strongin,A.Y.<br>Substrate cleavage analysis of furin and related proprotein convertases. A comparative study<br>J Biol Chem (2008) 283, 20897-20906. PubMed  Europe PubMed DOI  PMC  EPMC  P
    34. 2007
  34. Dikeakos,J.D., Mercure,C., Lacombe,M.J., Seidah,N.G. and Reudelhuber,T.L.<br>PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism<br>FEBS J (2007) 274, 4094-4102. PubMed  Europe PubMed DOI
  35. Leak,T.S., Keene,K.L., Langefeld,C.D., Gallagher,C.J., Mychaleckyj,J.C., Freedman,B.I., Bowden,D.W., Rich,S.S. and Sale,M.M.<br>Association of the proprotein convertase subtilisin/kexin-type 2 (PCSK2) gene with type 2 diabetes in an African American population<br>Mol Genet Metab (2007) 92, 145-150. PubMed  Europe PubMed DOI  PMC  EPMC  M
    36. 2006
  36. [YEAR:2-10-2006]Croissandeau,G., Wahnon,F., Yashpal,K., Seidah,N.G., Coderre,T.J., Chretien,M. and Mbikay,M.<br>Increased stress-induced analgesia in mice lacking the proneuropeptide convertase PC2<br>Neurosci Lett (2-10-2006) 406, 71-75. PubMed  Europe PubMed DOI  K
  37. Marzban,L., Rhodes,C.J., Steiner,D.F., Haataja,L., Halban,P.A. and Verchere,C.B.<br>Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death<br>Diabetes (2006) 55, 2192-2201. PubMed  Europe PubMed DOI
  38. [YEAR:11-8-2006]Pan,H., Che,F.Y., Peng,B., Steiner,D.F., Pintar,J.E. and Fricker,L.D.<br>The role of prohormone convertase-2 in hypothalamic neuropeptide processing: a quantitative neuropeptidomic study<br>J Neurochem (11-8-2006) 98, 1763-1777. PubMed  Europe PubMed DOI
  39. Scamuffa,N., Calvo,F., Chretien,M., Seidah,N.G. and Khatib,A.M.<br>Proprotein convertases: lessons from knockouts<br>FASEB J (2006) 20, 1954-1963. PubMed  Europe PubMed DOI  K  V
    40. 2005
  40. [YEAR:14-1-2005]Henrich,S., Lindberg,I., Bode,W. and Than,M.E.<br>Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity<br>J Mol Biol (14-1-2005) 345, 211-227. PubMed  Europe PubMed DOI  S
  41. [YEAR:23-6-2005]Tagen,M.B. and Beinfeld,M.C.<br>Recombinant prohormone convertase 1 and 2 cleave purified pro cholecystokinin (CCK) and a synthetic peptide containing CCK 8 Gly Arg Arg and the carboxyl-terminal flanking peptide<br>Peptides (23-6-2005) 26, 2530-2535. PubMed  Europe PubMed DOI
    42. 2004
  42. [YEAR:23-10-2004]Laurent,V., Jaubert-Miazza,L., Desjardins,R., Day,R. and Lindberg,I.<br>Biosynthesis of proopiomelanocortin-derived peptides in prohormone convertase 2 and 7B2 null mice<br>Endocrinology (23-10-2004) 145, 519-528. PubMed  Europe PubMed DOI
  43. [YEAR:4-8-2004]Ogiwara,K., Shinohara,M. and Takahashi,T.<br>Expression of proprotein convertase 2 mRNA in the ovarian follicles of the medaka, Oryzias latipes<br>Gene (4-8-2004) 337, 79-89. PubMed  Europe PubMed DOI
  44. Seidah,N.G. and Chretien,M.<br>Proprotein convertase 2<br>[ISSN:0-12-079610-4] (2004) 2, 1865-1868.  V
  45. [YEAR:28-5-2004]Webb,G.C., Dey,A., Wang,J., Stein,J., Milewski,M. and Steiner,D.F.<br>Altered proglucagon processing in an alpha-cell line derived from prohormone convertase 2 null mouse islets<br>J Biol Chem (28-5-2004) 279, 31068-31075. PubMed  Europe PubMed DOI
    46. 2003
  46. Cornwall,G.A., Cameron,A., Lindberg,I., Hardy,D.M., Cormier,N. and Hsia,N.<br>The cystatin-related epididymal spermatogenic protein inhibits the serine protease prohormone convertase 2<br>Endocrinology (2003) 144, 901-908. PubMed  Europe PubMed DOI
  47. [YEAR:28-3-2003]Doblinger,A., Becker,A., Seidah,N.G. and Laslop,A.<br>Proteolytic processing of chromogranin A by the prohormone convertase PC2<br>Regul Pept (28-3-2003) 111, 111-116. PubMed  Europe PubMed DOI
  48. [YEAR:28-2-2003]Li,Q.L., Naqvi,S., Shen,X., Liu,Y.J., Lindberg,I. and Friedman,T.C.<br>Prohormone convertase 2 enzymatic activity and its regulation in neuro-endocrine cells and tissues<br>Regul Pept (28-2-2003) 110, 197-205. PubMed  Europe PubMed DOI
  49. Miller,R., Aaron,W., Toneff,T., Vishnuvardhan,D., Beinfeld,M.C. and Hook,V.Y.<br>Obliteration of alpha-melanocyte-stimulating hormone derived from POMC in pituitary and brains of PC2-deficient mice<br>J Neurochem (2003) 86, 556-563. PubMed  Europe PubMed DOI  K
  50. Peinado,J.R., Li,H., Johanning,K. and Lindberg,I.<br>Cleavage of recombinant proenkephalin and blockade mutants by prohormone convertases 1 and 2: an in vitro specificity study<br>J Neurochem (2003) 87, 868-878. PubMed  Europe PubMed DOI
  51. Rayburn,L.Y., Gooding,H.C., Choksi,S.P., Maloney,D., Kidd,A.R., III, Siekhaus,D.E. and Bender,M.<br>amontillado, the Drosophila homolog of the prohormone processing protease PC2, is required during embryogenesis and early larval development<br>Genetics (2003) 163, 227-237. PubMed  Europe PubMed  PMC  EPMC
  52. Taylor,N.A., Van de Ven,W.J. and Creemers,J.W.<br>Curbing activation: proprotein convertases in homeostasis and pathology<br>FASEB J (2003) 17, 1215-1227. PubMed  Europe PubMed DOI  K
  53. Vincent,M., Guz,Y., Rozenberg,M., Webb,G., Furuta,M., Steiner,D. and Teitelman,G.<br>Abrogation of protein convertase 2 activity results in delayed islet cell differentiation and maturation, increased alpha-cell proliferation, and islet neogenesis<br>Endocrinology (2003) 144, 4061-4069. PubMed  Europe PubMed DOI  K
  54. Winsky-Sommerer,R., Grouselle,D., Rougeot,C., Laurent,V., David,J.P., Delacourte,A., Dournaud,P., Seidah,N.G., Lindberg,I., Trottier,S. and Epelbaum,J.<br>The proprotein convertase PC2 is involved in the maturation of prosomatostatin to somatostatin-14 but not in the somatostatin deficit in Alzheimer's disease<br>Neuroscience (2003) 122, 437-447. PubMed  Europe PubMed DOI
    55. 2002
  55. Fugere,M. and Day,R.<br>Inhibitors of the subtilase-like pro-protein convertases (SPCs)<br>Curr Pharm Des (2002) 8, 549-562. PubMed  Europe PubMed DOI  V  I
  56. Kovaleva,E.S., Yakovlev,A.G., Masler,E.P. and Chitwood,D.J.<br>Human proprotein convertase 2 homologue from a plant nematode: Cloning, characterization, and comparison with other species<br>FASEB J (2002) 16, 1099-1101. PubMed  Europe PubMed DOI
  57. [YEAR:5-3-2002]Laurent,V., Kimble,A., Peng,B., Zhu,P., Pintar,J.E., Steiner,D.F. and Lindberg,I.<br>Mortality in 7B2 null mice can be rescued by adrenalectomy: involvement of dopamine in ACTH hypersecretion<br>Proc Natl Acad Sci U S A (5-3-2002) 99, 3087-3092. PubMed  Europe PubMed DOI  PMC  EPMC
  58. Seidah,N.G. and Prat,A.<br>Precursor convertases in the secretory pathway, cytosol and extracellular milieu<br>Essays Biochem (2002) 38, 79-94. PubMed  Europe PubMed
  59. Villeneuve,P., Feliciangeli,S., Croissandeau,G., Seidah,N.G., Mbikay,M., Kitabgi,P. and Beaudet,A.<br>Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study<br>J Neurochem (2002) 82, 783-793. PubMed  Europe PubMed DOI  K
    60. 2001
  60. [YEAR:20-7-2001]Furuta,M., Zhou,A., Webb,G., Carroll,R., Ravazzola,M., Orci,L. and Steiner,D.F.<br>Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice<br>J Biol Chem (20-7-2001) 276, 27197-27202. PubMed  Europe PubMed DOI  K
  61. Wang,J., Xu,J., Finnerty,J., Furuta,M., Steiner,D.F. and Verchere,C.B.<br>The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site<br>Diabetes (2001) 50, 534-539. PubMed  Europe PubMed
    62. 2000
  62. Berman,Y., Mzhavia,N., Polonskaia,A., Furuta,M., Steiner,D.F., Pintar,J.E. and Devi,L.A.<br>Defective prodynorphin processing in mice lacking prohormone convertase PC2<br>J Neurochem (2000) 75, 1763-1770. PubMed  Europe PubMed DOI  K
  63. Brakch,N., Rholam,M., Simonetti,M. and Cohen,P.<br>Favourable side-chain orientation of cleavage site dibasic residues of prohormone in proteolytic processing by prohormone convertase 1/3<br>Eur J Biochem (2000) 267, 1626-1633. PubMed  Europe PubMed DOI
  64. [YEAR:9-6-2000]Hwang,J.R., Siekhaus,D.E., Fuller,R.S., Taghert,P.H. and Lindberg,I.<br>Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2. Insect cell-specific processing and secretion<br>J Biol Chem (9-6-2000) 275, 17886-17893. PubMed  Europe PubMed DOI
  65. Hwang,S.R., Ng,S.M., Steineckert,B., Seidah,N.G. and Hook,V.Y.H.<br>Molecular cloning demonstrates structural features of homologous bovine prohormone convertases 1 and 2<br>DNA Cell Biol (2000) 19, 409-419. PubMed  Europe PubMed DOI
  66. [YEAR:15-12-2000]Muller,L., Cameron,A., Fortenberry,Y., Apletalina,E.V. and Lindberg,I.<br>Processing and sorting of the prohormone convertase 2 propeptide<br>J Biol Chem (15-12-2000) 275, 39213-39222. PubMed  Europe PubMed DOI
  67. [YEAR:28-8-2000]Villeneuve,P., Lafortune,L., Seidah,N.G., Kitabgi,P. and Beaudet,A.<br>Immunohistochemical evidence for the involvement of protein convertases 5A and 2 in the processing of pro-neurotensin in rat brain<br>J Comp Neurol (28-8-2000) 424, 461-475. PubMed  Europe PubMed DOI
  68. [YEAR:28-8-2000]Winsky-Sommerer,R., Benjannet,S., Rovere,C., Barbero,P., Seidah,N.G., Epelbaum,J. and Dournaud,P.<br>Regional and cellular localization of the neuroendocrine prohormone convertases PC1 and PC2 in the rat central nervous system<br>J Comp Neurol (28-8-2000) 424, 439-460. PubMed  Europe PubMed
    69. 1999
  69. Fortenberry,Y., Liu,J. and Lindberg,I.<br>The role of the 7B2 CT peptide in the inhibition of prohormone convertase 2 in endocrine cell lines<br>J Neurochem (1999) 73, 994-1003. PubMed  Europe PubMed DOI
  70. Lamango,N.S., Apletalina,E., Liu,J. and Lindberg,I.<br>The proteolytic maturation of prohormone convertase 2 (PC2) is a pH-driven process<br>Arch Biochem Biophys (1999) 362, 275-282. PubMed  Europe PubMed DOI
  71. Muller,L. and Lindberg,I.<br>The cell biology of the prohormone convertases PC1 and PC2<br>Prog Nucleic Acid Res Mol Biol (1999) 63, 69-108. PubMed  Europe PubMed
  72. [YEAR:23-7-1999]Muller,L., Zhu,P., Juliano,M.A., Juliano,L. and Lindberg,I.<br>A 36-residue peptide contains all of the information required for 7B2-mediated activation of prohormone convertase 2<br>J Biol Chem (23-7-1999) 274, 21471-21477. PubMed  Europe PubMed DOI
  73. Seidah,N.G., Benjannet,S., Hamelin,J., Mamarbachi,A.M., Basak,A., Marcinkiewicz,J., Mbikay,M., Chretien,M. and Marcinkiewicz,M.<br>The subtilisin/kexin family of precursor convertases. Emphasis on PC1, PC2/7B2, POMC and the novel enzyme SKI-1<br>Ann N Y Acad Sci (1999) 885, 57-74. PubMed  Europe PubMed
  74. [YEAR:15-8-1999]Siekhaus,D.E. and Fuller,R.S.<br>A role for amontillado, the Drosophila homolog of the neuropeptide precursor processing protease PC2, in triggering hatching behavior<br>J Neurosci (15-8-1999) 19, 6942-6954. PubMed  Europe PubMed
    75. 1998
  75. [YEAR:22-5-1998]Benjannet,S., Mamarbachi,A.M., Hamelin,J., Savaria,D., Munzer,J.S., Chretien,M. and Seidah,N.G.<br>Residues unique to the pro-hormone convertase PC2 modulate its autoactivation, binding to 7B2 and enzymatic activity<br>FEBS Lett (22-5-1998) 428, 37-42. PubMed  Europe PubMed DOI
  76. [YEAR:9-1-1998]Day,R., Lazure,C., Basak,A., Boudreault,A., Limperis,P., Dong,W. and Lindberg,I.<br>Prodynorphin processing by proprotein convertase 2. Cleavage at single basic residues and enhanced processing in the presence of carboxypeptidase activity<br>J Biol Chem (9-1-1998) 273, 829-836. PubMed  Europe PubMed DOI  I
  77. [YEAR:15-9-1998]Scougall,K., Taylor,N.A., Jermany,J.L., Docherty,K. and Shennan,K.I.<br>Differences in the autocatalytic cleavage of pro-PC2 and pro-PC3 can be attributed to sequences within the propeptide and Asp310 of pro-PC2<br>Biochem J (15-9-1998) 334, 531-537. PubMed  Europe PubMed  PMC  EPMC
  78. [YEAR:13-2-1998]Van Horssen,A.M. and Martens,G.J.<br>Mapping of the domain in the neuroendocrine protein 7B2 important for its helper function towards prohormone convertase PC2<br>Mol Cell Endocrinol (13-2-1998) 137, 7-12. PubMed  Europe PubMed DOI
    79. 1997
  79. [YEAR:24-6-1997]Furuta,M., Yano,H., Zhou,A., Rouille,Y., Holst,J.J., Carroll,R., Ravazzola,M., Orci,L., Furuta,H. and Steiner,D.F.<br>Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2<br>Proc Natl Acad Sci U S A (24-6-1997) 94, 6646-6651. PubMed  Europe PubMed DOI  PMC  EPMC  K
  80. Rouille,Y., Bianchi,M., Irminger,J.C. and Halban,P.A.<br>Role of the prohormone convertase PC2 in the processing of proglucagon to glucagon<br>FEBS Lett (1997) 413, 119-123. PubMed  Europe PubMed
  81. Urbe,S., Dittie,A.S. and Tooze,S.A.<br>pH-dependent processing of secretogranin II by the endopeptidase PC2 in isolated immature secretory granules<br>Biochem J (1997) 321, 65-74. PubMed  Europe PubMed  PMC  EPMC
    82. 1996
  82. Johanning,K., Mathis,J.P. and Lindberg,I.<br>Role of PC2 in proenkephalin processing: antisense and overexpression studies<br>J Neurochem (1996) 66, 898-907. PubMed  Europe PubMed
  83. Lamango,N.S., Zhu,X. and Lindberg,I.<br>Purification and enzymatic characterization of recombinant prohormone convertase 2: Stabilization of activity by 21 kDa 7B2<br>Arch Biochem Biophys (1996) 330, 238-250. PubMed  Europe PubMed DOI
  84. Paquet,L., Zhou,A., Chang,E.Y. and Mains,R.E.<br>Peptide biosynthetic processing: Distinguishing prohormone convertases PC1 and PC2<br>Mol Cell Endocrinol (1996) 120, 161-168. PubMed  Europe PubMed DOI
  85. Rovere,C., Barbero,P. and Kitabgi,P.<br>Evidence that PC2 is the endogenous pro-neurotensin convertase in rMTC 6-23 cells and that PC1- and PC2-transfected PC12 cells differentially process pro-neurotensin<br>J Biol Chem (1996) 271, 11368-11375. PubMed  Europe PubMed
  86. Zhu,X., Lamango,N.S. and Lindberg,I.<br>Involvement of a polyproline helix-like structure in the interaction of 7B2 with prohormone convertase 2<br>J Biol Chem (1996) 271, 23582-23587. PubMed  Europe PubMed DOI
  87. [YEAR:14-5-1996]Zhu,X., Rouille,Y., Lamango,N.S., Steiner,D.F. and Lindberg,I.<br>Internal cleavage of the inhibitory 7B2 carboxyl-terminal peptide by PC2: a potential mechanism for its inactivation<br>Proc Natl Acad Sci U S A (14-5-1996) 93, 4919-4924. PubMed  Europe PubMed DOI  PMC  EPMC
    88. 1995
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