Sequence features for peptidase S08.073: PCSK2 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

 

MERNUM Species Sequence length Peptidase unit Active site residues Source
MER0689558 Acanthisitta chloris 579 83-380 D108, H149, D251, S325 GENBANK:XP_009080702
MER0022880 Achatina fulica 47 1-47 missing, missing, N5, missing UNIPROT:O18322
MER0022880 Achatina fulica 47 1-47 missing, missing, N5, missing UNIPROT:O18322
MER0269485 Ailuropoda melanoleuca 599 103-399 D128, H169, D271, S345 GENBANK:XP_002925124
MER0289757 Alligator mississippiensis 637 141-438 D166, H207, D309, S383 GENBANK:XP_006260761
MER0293993 Alligator sinensis 637 141-438 D166, H207, D309, S383 GENBANK:XP_006035773
MER0325309 Amphimedon queenslandica 267 78-263 D100, H137, N238, missing GENBANK:XP_003391117
MER0332417 Anas platyrhynchos 612 116-413 D141, H182, D284, S358 GENBANK:XP_005010893
MER0325293 Anolis carolinensis 597 144-397 D169, H210, D269, S343 GENBANK:XP_003215289
MER0607038 Anolis carolinensis 640 144-441 D169, H210, D312, S386 GENBANK:XP_008113200
MER0687091 Aptenodytes forsteri 608 112-409 D137, H178, D280, S354 GENBANK:XP_009280840
MER0685575 Aquila chrysaetos 636 140-437 D165, H206, D308, S382 GENBANK:XP_011600249
MER0554726 Astatotilapia burtoni 641 144-441 D169, H210, D312, S386 GENBANK:XP_005914156
MER0381365 Astyanax mexicanus 641 144-441 D169, H210, D312, S386 UNIPROT:W5K8C7
MER0381365 Astyanax mexicanus 641 144-441 D169, H210, D312, S386 UNIPROT:W5K8C7
MER0399757 Balaenoptera acutorostrata 638 142-439 D167, H208, D310, S384 GENBANK:XP_007181892
MER0682097 Balearica regulorum 544 48-345 D73, H114, D216, S290 GENBANK:XP_010296554
MER0679994 Bison bison 638 142-439 D167, H208, D310, S384 GENBANK:XP_010858347
MER0005970 Bos taurus 638 142-439 D167, H208, D310, S384 UNIPROT:Q9GLR0
MER0005970 Bos taurus 638 142-439 D167, H208, D310, S384 UNIPROT:Q9GLR0
MER0005970 Bos taurus 638 142-439 D167, H208, D310, S384 UNIPROT:Q9GLR0
MER0005970 Bos taurus 638 142-439 D167, H208, D310, S384 UNIPROT:Q9GLR0
MER0005970 Bos taurus 638 142-439 D167, H208, D310, S384 UNIPROT:Q9GLR0
MER0001993 Branchiostoma californiense 688 139-446 D174, H215, D317, S391 UNIPROT:Q17123
MER0001993 Branchiostoma californiense 688 139-446 D174, H215, D317, S391 UNIPROT:Q17123
MER0678841 Buceros rhinoceros 579 83-380 D108, H149, D251, S325 GENBANK:XP_010140995
MER0325176 Callithrix jacchus 638 142-438 D167, H208, D310, S384 UNIPROT:F7I5R7
MER0325176 Callithrix jacchus 638 142-438 D167, H208, D310, S384 UNIPROT:F7I5R7
MER0581832 Calypte anna 637 141-438 D166, H207, D309, S383 GENBANK:XP_008499132
MER0677505 Camelus dromedarius 638 142-439 D167, H208, D310, S384 GENBANK:XP_010984370
MER0162627 Canis lupus familiaris 638 142-439 D167, H208, D310, S384 GENBANK:XP_542880
MER0675211 Cariama cristata 579 83-380 D108, H149, D251, S325 GENBANK:XP_009702523
MER0103548 Cavia porcellus 629 133-429 D158, H199, D301, S375 GENBANK:XP_003476431
MER0396732 Ceratotherium simum 638 142-439 D167, H208, D310, S384 GENBANK:XP_004433788
MER0585579 Cercopithecus sabaeus 638 142-439 D167, H208, D310, S384 GENBANK:XP_007958917
MER0673184 Chaetura pelagica 661 165-462 D190, H231, D333, S407 GENBANK:XP_009998495
MER0672230 Charadrius vociferus 588 92-389 D117, H158, D260, S334 GENBANK:XP_009879727
MER0591328 Chelonia mydas 639 143-440 D168, H209, D311, S385 GENBANK:XP_007064195
MER0584313 Chinchilla lanigera 638 142-439 D167, H208, D310, S384 GENBANK:XP_005380961
MER0574672 Chrysochloris asiatica 639 143-440 D168, H209, D311, S385 GENBANK:XP_006860689
MER0090873 Ciona intestinalis 660 147-469 D192, H233, D335, S409 GENBANK:NP_001128498
MER0668943 Colobus angolensis 638 142-439 D167, H208, D310, S384 GENBANK:XP_011818138
MER0578714 Columba livia 592 96-393 D121, H162, D264, S338 GENBANK:XP_005505052
MER0572856 Corvus brachyrhynchos 616 120-417 D145, H186, D288, S362 GENBANK:XP_008633691
MER0668527 Corvus cornix 636 119-437 D144, H206, D308, S382 GENBANK:XP_010409253
MER0309562 Cricetulus griseus 637 141-437 D166, H207, D309, S383 GENBANK:XP_003508161
MER0665384 Cuculus canorus 675 179-476 D204, H245, D347, S421 GENBANK:XP_009554865
MER0568054 Cynoglossus semilaevis 641 144-441 D169, H210, D312, S386 GENBANK:XP_008320675
MER0161543 Danio rerio 646 138-445 D173, H214, D316, S390 UNIPROT:B6VCA2
MER0161543 Danio rerio 646 138-445 D173, H214, D316, S390 UNIPROT:B6VCA2
MER0603002 Dasypus novemcinctus 579 83-380 D108, H149, D251, S325 GENBANK:XP_004472456
MER0599746 Echinops telfairi 639 143-440 D168, H209, D311, S385 GENBANK:XP_004697873
MER0664093 Egretta garzetta 604 108-405 D133, H174, D276, S350 GENBANK:XP_009632969
MER0565495 Elephantulus edwardii 638 142-439 D167, H208, D310, S384 GENBANK:XP_006902144
MER0563631 Eptesicus fuscus 638 142-439 D167, H208, D310, S384 GENBANK:XP_008139332
MER0098403 Equus caballus 638 141-438 M166, S207, G309, T383 GENBANK:XP_001491641
MER0562089 Equus przewalskii 642 146-443 D171, H212, D314, S388 GENBANK:XP_008534946
MER0615535 Erinaceus europaeus 639 143-440 D168, H209, D311, S385 GENBANK:XP_007525786
MER0661275 Esox lucius 641 145-442 D170, H211, D313, S387 GENBANK:XP_010868444
MER0560305 Falco cherrug 656 160-457 D185, H226, D328, S402 GENBANK:XP_005445701
MER0545626 Falco peregrinus 687 191-488 D216, H257, D359, S433 GENBANK:XP_005238693
MER0610852 Felis catus 638 142-439 D167, H208, D310, S384 GENBANK:XP_003983848
MER0569390 Ficedula albicollis 714 218-515 D243, H284, D386, S460 GENBANK:XP_005042995
MER0655325 Fukomys damarensis 638 132-439 D167, H208, D310, S384 GENBANK:XP_010632428
MER0558653 Galeopterus variegatus 638 142-439 D167, H208, D310, S384 GENBANK:XP_008586707
MER0054114 Gallus gallus 641 112-439 G137, F208, A310, S384 GENBANK:XP_419332
MER0606547 Gallus gallus 644 148-445 D173, H214, D316, S390 UNIPROT:F1NUG0
MER0606547 Gallus gallus 644 148-445 D173, H214, D316, S390 UNIPROT:F1NUG0
MER0559461 Geospiza fortis 620 124-421 D149, H190, D292, S366 GENBANK:XP_005425872
MER0609627 Gorilla gorilla 638 142-439 D167, H208, D310, S384 UNIPROT:G3QWE4
MER0609627 Gorilla gorilla 638 142-439 D167, H208, D310, S384 UNIPROT:G3QWE4
MER0652010 Haliaeetus leucocephalus 638 142-439 D167, H208, D310, S384 GENBANK:XP_010573355
MER0028254 Halocynthia roretzi 642 151-458 D186, H227, D329, S403 UNIPROT:Q8MXZ6
MER0028254 Halocynthia roretzi 642 151-458 D186, H227, D329, S403 UNIPROT:Q8MXZ6
MER0325149 Heterocephalus glaber 545 49-345 D74, H115, D217, S291 UNIPROT:G5CB99
MER0325149 Heterocephalus glaber 545 49-345 D74, H115, D217, S291 UNIPROT:G5CB99
MER0974922 Hofstenia miamia 600 113-420 D148, H189, D291, S365 UNIPROT:A0A068CMX6
MER0974922 Hofstenia miamia 600 113-420 D148, H189, D291, S365 UNIPROT:A0A068CMX6
MER0000377 Homo sapiens 638 142-439 D167, H208, D310, S384 PIR:KXHUC2
MER0000377 Homo sapiens 638 142-439 D167, H208, D310, S384 PIR:KXHUC2
MER0547571 Jaculus jaculus 638 142-439 D167, H208, D310, S384 GENBANK:XP_004668780
MER0649408 Larimichthys crocea 641 144-441 D169, H210, D312, S386 GENBANK:XP_010743900
MER0611693 Latimeria chalumnae 702 145-503 D170, H272, D374, S448 GENBANK:XP_005996936
MER0554532 Lepisosteus oculatus 641 145-442 D170, H211, D313, S387 UNIPROT:W5NGE3
MER0554532 Lepisosteus oculatus 641 145-442 D170, H211, D313, S387 UNIPROT:W5NGE3
MER0552986 Leptonychotes weddellii 638 142-439 D167, H208, D310, S384 GENBANK:XP_006744311
MER0980111 Leptosomus discolor 579 74-381 D109, H150, D252, S326 UNIPROT:A0A091Q533
MER0980111 Leptosomus discolor 579 74-381 D109, H150, D252, S326 UNIPROT:A0A091Q533
MER0549595 Lipotes vexillifer 638 142-439 D167, H208, D310, S384 GENBANK:XP_007461853
MER0259452 Loxodonta africana 638 142-438 D167, H208, D310, S384 UNIPROT:G3UKG4
MER0259452 Loxodonta africana 638 142-438 D167, H208, D310, S384 UNIPROT:G3UKG4
MER0164277 Macaca fascicularis 638 142-439 D167, H208, D310, S384 GENBANK:EHH65564
MER0158371 Macaca mulatta 638 142-439 D167, H208, D310, S384 GENBANK:XP_001087532
MER0647059 Manacus vitellinus 588 92-389 D117, H158, D260, S334 GENBANK:XP_008931247
MER0645273 Mandrillus leucophaeus 638 142-439 D167, H208, D310, S384 GENBANK:XP_011834856
MER0542447 Maylandia zebra 641 144-441 D169, H210, D312, S386 GENBANK:XP_004551646
MER0325179 Meleagris gallopavo 682 186-482 D211, H252, D354, S428 GENBANK:XP_003203723
MER0540838 Melopsittacus undulatus 605 109-406 D134, H175, D277, S351 GENBANK:XP_005147551
MER0644174 Merops nubicus 579 83-380 D108, H149, D251, S325 GENBANK:XP_008946758
MER0538770 Microtus ochrogaster 637 141-438 D166, H207, D309, S383 GENBANK:XP_005365576
MER0172563 Monodelphis domestica 639 143-440 D168, H209, D311, S385 GENBANK:XP_001382112
MER0000380 Mus musculus 736 240-537 D265, H306, D408, S482 UNIPROT:Q3TT48
MER0000380 Mus musculus 736 240-537 D265, H306, D408, S482 UNIPROT:Q3TT48
MER0000380 Mus musculus 736 240-537 D265, H306, D408, S482 UNIPROT:Q3TT48
MER0000380 Mus musculus 736 240-537 D265, H306, D408, S482 UNIPROT:Q3TT48
MER0169312 Mus spretus 637 141-438 D166, H207, D309, S383 UNIPROT:A8QKA8
MER0169312 Mus spretus 637 141-438 D166, H207, D309, S383 UNIPROT:A8QKA8
MER0577828 Myotis brandtii 638 142-439 D167, H208, D310, S384 GENBANK:XP_005860645
MER0613230 Myotis davidii 638 142-439 D167, H208, D310, S384 GENBANK:XP_006776176
MER0641348 Nannospalax galili 638 142-439 D167, H208, D310, S384 GENBANK:XP_008848489
MER0536071 Neolamprologus brichardi 641 144-441 D169, H210, D312, S386 GENBANK:XP_006783834
MER0973960 Neovison vison 638 132-439 D167, H208, D310, S384 UNIPROT:U6CVE4
MER0973960 Neovison vison 638 132-439 D167, H208, D310, S384 UNIPROT:U6CVE4
MER0634565 Nestor notabilis 579 83-380 D108, H149, D251, S325 GENBANK:XP_010020476
MER0635900 Nipponia nippon 592 96-393 D121, H162, D264, S338 GENBANK:XP_009474493
MER0257748 Nomascus leucogenys 638 142-438 D167, H208, D310, S384 UNIPROT:G1REW0
MER0257748 Nomascus leucogenys 638 142-438 D167, H208, D310, S384 UNIPROT:G1REW0
MER0635400 Notothenia coriiceps 641 144-441 D169, H210, D312, S386 GENBANK:XP_010781520
MER0533580 Ochotona princeps 638 142-439 D167, H208, D310, S384 GENBANK:XP_004598229
MER0532647 Octodon degus 638 142-439 D167, H208, D310, S384 GENBANK:XP_004635662
MER0531139 Odobenus rosmarus 638 142-439 D167, H208, D310, S384 GENBANK:XP_004412353
MER0969065 Ophiophagus hannah 640 134-441 D169, H210, D312, S386 UNIPROT:V8PH66
MER0969065 Ophiophagus hannah 640 134-441 D169, H210, D312, S386 UNIPROT:V8PH66
MER0529391 Orcinus orca 638 142-439 D167, H208, D310, S384 GENBANK:XP_004270441
MER0325123 Oreochromis niloticus 641 144-440 D169, H210, D312, S386 UNIPROT:I3IUZ6
MER0325123 Oreochromis niloticus 641 144-440 D169, H210, D312, S386 UNIPROT:I3IUZ6
MER0097919 Ornithorhynchus anatinus 639 142-439 M167, S208, G310, T384 GENBANK:XP_001515414
MER0528487 Orycteropus afer 638 142-439 D167, H208, D310, S384 GENBANK:XP_007953569
MER0110532 Oryctolagus cuniculus 638 142-438 D167, H208, D310, S384 UNIPROT:G1TAG6
MER0110532 Oryctolagus cuniculus 638 142-438 D167, H208, D310, S384 UNIPROT:G1TAG6
MER0110859 Oryzias latipes 641 144-441 D169, H210, D312, S386 GENBANK:XP_004077146
MER0402979 Otolemur garnettii 775 142-576 D167, H345, D447, S521 GENBANK:XP_003801377
MER0005973 Ovis aries 638 142-439 D167, H208, D310, S384 GENBANK:XP_004014332
MER0403016 Pan paniscus 638 142-439 D167, H208, D310, S384 GENBANK:XP_003810641
MER0077182 Pan troglodytes 638 142-439 D167, H208, D310, S384 UNIPROT:H2QJZ8
MER0077182 Pan troglodytes 638 142-439 D167, H208, D310, S384 UNIPROT:H2QJZ8
MER0518532 Panthera tigris 638 142-439 D167, H208, D310, S384 GENBANK:XP_007096591
MER0525633 Papio anubis 638 142-439 D167, H208, D310, S384 UNIPROT:A0A096NVM0
MER0525633 Papio anubis 638 142-439 D167, H208, D310, S384 UNIPROT:A0A096NVM0
MER0988163 Pelodiscus sinensis 518 12-319 D47, H88, D190, S264, GENBANK:-
MER0308766 Phaethon lepturus 544 48-345 D73, H114, D216, S290 GENBANK:XP_010293105
MER0631265 Phalacrocorax carbo 579 83-380 D108, H149, D251, S325 GENBANK:XP_009506223
MER0520807 Physeter catodon 638 142-439 D167, H208, D310, S384 GENBANK:XP_007100416
MER0628684 Picoides pubescens 736 240-537 D265, H306, D408, S482 GENBANK:XP_009905219
MER0522899 Poecilia formosa 642 145-442 D170, H211, D313, S387 GENBANK:XP_007545339
MER0513471 Poecilia reticulata 642 145-442 D170, H211, D313, S387 GENBANK:XP_008427629
MER0143431 Pongo abelii 638 142-439 D167, H208, D310, S384 UNIPROT:Q5REC2
MER0143431 Pongo abelii 638 142-439 D167, H208, D310, S384 UNIPROT:Q5REC2
MER0143431 Pongo abelii 638 142-439 D167, H208, D310, S384 UNIPROT:Q5REC2
MER0515631 Pteropus alecto 638 142-439 D167, H208, D310, S384 GENBANK:XP_006921634
MER0978249 Pteropus alecto 683 97-484 D132, H173, D355, S429 UNIPROT:L5JY16
MER0978249 Pteropus alecto 683 97-484 D132, H173, D355, S429 UNIPROT:L5JY16
MER0442162 Python bivittatus 640 144-441 D169, H210, D312, S386 GENBANK:XP_007428346
MER0042896 Rana catesbeiana 638 132-439 D167, H208, D310, S384 UNIPROT:Q76FG0
MER0042896 Rana catesbeiana 638 132-439 D167, H208, D310, S384 UNIPROT:Q76FG0
MER0005976 Rana ridibunda 636 130-437 D165, H206, D308, S382 UNIPROT:O93577
MER0005976 Rana ridibunda 636 130-437 D165, H206, D308, S382 UNIPROT:O93577
MER0000387 Rattus norvegicus 637 141-438 D166, H207, D309, S383 GENBANK:NP_036878
MER0000387 Rattus norvegicus 637 141-438 D166, H207, D309, S383 GENBANK:NP_036878
MER0000387 Rattus norvegicus 637 141-438 D166, H207, D309, S383 GENBANK:NP_036878
MER0562577 Rhinopithecus roxellana 638 142-439 D167, H208, D310, S384 GENBANK:XP_010379770
MER0512384 Saimiri boliviensis 638 142-439 D167, H208, D310, S384 GENBANK:XP_003933229
MER0140685 Salmo salar 641 145-441 D170, H211, D313, S387 UNIPROT:B5X255
MER0140685 Salmo salar 641 145-441 D170, H211, D313, S387 UNIPROT:B5X255
MER0403024 Sarcophilus harrisii 604 108-405 D133, H174, D276, S350 GENBANK:XP_003758219
MER0541745 Serinus canaria 639 143-440 D168, H209, D311, S385 GENBANK:XP_009095415
MER0597094 Sorex araneus 638 142-439 D167, H208, D310, S384 GENBANK:XP_004610967
MER0476550 Stegastes partitus 643 146-443 D171, H212, D314, S388 GENBANK:XP_008277756
MER0972278 Strix aluco 398 91-390 D126, H167, D269, S343 UNIPROT:U3Q3X0
MER0972278 Strix aluco 398 91-390 D126, H167, D269, S343 UNIPROT:U3Q3X0
MER0077858 Strongylocentrotus purpuratus 646 50-348 D75, H116, D218, S293 GENBANK:XP_785694
MER0974821 Strongylocentrotus purpuratus 751 152-463 D190, H231, D333, S408 GENBANK:-
MER0974821 Strongylocentrotus purpuratus 751 152-463 D190, H231, D333, S408 GENBANK:-
MER0520661 Struthio camelus 568 72-369 D97, H138, D240, S314 GENBANK:XP_009672292
MER0001500 Sus scrofa 638 142-439 D167, H208, D310, S384 GENBANK:-
MER0001500 Sus scrofa 638 142-439 D167, H208, D310, S384 GENBANK:-
MER0160823 Taeniopygia guttata 725 229-526 D254, H295, D397, S471 GENBANK:XP_002197444
MER0266811 Takifugu rubripes 641 144-441 D169, H210, D312, S386 GENBANK:XP_003964043
MER0140597 Tetraodon nigroviridis 640 134-441 D169, H210, D312, S386 UNIPROT:Q4SL62
MER0140597 Tetraodon nigroviridis 640 134-441 D169, H210, D312, S386 UNIPROT:Q4SL62
MER0474654 Tinamus guttatus 606 110-407 D135, H176, D278, S352 GENBANK:XP_010209689
MER0483445 Trichechus manatus 638 142-439 D167, H208, D310, S384 GENBANK:XP_004376507
MER0598843 Tupaia chinensis 638 142-439 D167, H208, D310, S384 GENBANK:XP_006143710
MER0262644 Tursiops truncatus 638 142-439 D167, H208, D310, S384 GENBANK:XP_004311488
MER0452081 Tyto alba 544 48-345 D73, H114, D216, S290 GENBANK:XP_009962213
MER0200155 Ursus maritimus 638 142-439 D167, H208, D310, S384 GENBANK:XP_008708233
MER0615431 Vicugna pacos 601 142-402 D167, H208, D273, S347 GENBANK:XP_006206263
MER0002731 Xenopus laevis 639 143-440 D168, H209, D311, S385 UNIPROT:Q6GM20
MER0002731 Xenopus laevis 639 143-440 D168, H209, D311, S385 UNIPROT:Q6GM20
MER0090843 Xenopus tropicalis 639 143-439 D168, H209, D311, S385 GENBANK:NP_001090660
MER0454448 Xiphophorus maculatus 642 145-442 D170, H211, D313, S387 UNIPROT:M4A863
MER0454448 Xiphophorus maculatus 642 145-442 D170, H211, D313, S387 UNIPROT:M4A863
MER0449722 Zonotrichia albicollis 589 93-390 D118, H159, D261, S335 GENBANK:XP_005496107