Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P01275

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
20	unknown peptidase	1-180	P		NT	<%Agarwal et al., 2012[]%>
52	PCSK2 peptidase	21-178	P			<%Enzyme Nomenclature, 1996[]%>
55	ALE1 peptidase	53-81	P			Cedzich et al., 2009
55	SlSBT3 g.p. (Solanum lycopersicum)	53-81	N			Cedzich et al., 2009
55	tripeptidyl-peptidase I	53-81	P	normal turnover	MS	Vines & Warburton, 1998
58	tripeptidyl-peptidase I	56-81	P	normal turnover	MS	Vines & Warburton, 1998
59	RD21 peptidase	53-81	N			Kikuchi et al., 2008
59	ALE1 peptidase	53-81	P			Cedzich et al., 2009
60	SlSBT3 g.p. (Solanum lycopersicum)	53-81	N			Cedzich et al., 2009
61	carboxypeptidase O	53-62	N			Dal Degan et al., 1992
61	tripeptidyl-peptidase I	59-81	P	normal turnover	MS	Vines & Warburton, 1998
62	carboxypeptidase O	53-63	N			Dal Degan et al., 1992
63	Mername-AA083 peptidase	53-64	N			Dal Degan et al., 1992
63	carboxypeptidase O	53-64	N			Dal Degan et al., 1992
64	cathepsin B-like cysteine peptidase (Raphanus sativus)	53-81	N			Tsuji et al., 2008
64	Mername-AA083 peptidase	53-65	N			Dal Degan et al., 1992
64	carboxypeptidase O	53-65	N			Dal Degan et al., 1992
64	tripeptidyl-peptidase I	62-81	P	normal turnover	MS	Vines & Warburton, 1998
65	Mername-AA083 peptidase	53-66	N			Dal Degan et al., 1992
65	carboxypeptidase O	53-66	N			Dal Degan et al., 1992
66	cathepsin B-like cysteine peptidase (Raphanus sativus)	53-81	N			Tsuji et al., 2008
66	Mername-AA083 peptidase	53-67	N			Dal Degan et al., 1992
66	carboxypeptidase O	53-67	N			Dal Degan et al., 1992
67	RD21 peptidase	53-81	N			Kikuchi et al., 2008
67	Mername-AA083 peptidase	53-68	N			Dal Degan et al., 1992
67	carboxypeptidase O	53-68	N			Dal Degan et al., 1992
67	tripeptidyl-peptidase I	65-81	P	normal turnover	MS	Vines & Warburton, 1998
68	Mername-AA083 peptidase	53-69	N			Dal Degan et al., 1992
68	carboxypeptidase O	53-69	N			Dal Degan et al., 1992
69	Mername-AA083 peptidase	53-70	N			Dal Degan et al., 1992
69	carboxypeptidase O	53-70	N			Dal Degan et al., 1992
70	cathepsin B-like cysteine peptidase (Raphanus sativus)	53-81	N			Tsuji et al., 2008
70	Mername-AA083 peptidase	53-71	N			Dal Degan et al., 1992
70	carboxypeptidase O	53-71	N			Dal Degan et al., 1992
70	tripeptidyl-peptidase I	68-81	P	normal turnover	MS	Vines & Warburton, 1998
71	Mername-AA083 peptidase	53-72	N			Dal Degan et al., 1992
71	carboxypeptidase O	53-72	N			Dal Degan et al., 1992
72	meprin alpha subunit	53-81	P			Bertenshaw et al., 2001
72	ALE1 peptidase	53-81	P			Cedzich et al., 2009
72	SlSBT3 g.p. (Solanum lycopersicum)	53-81	N			Cedzich et al., 2009
72	Mername-AA083 peptidase	53-73	N			Dal Degan et al., 1992
72	carboxypeptidase O	53-73	N			Dal Degan et al., 1992
73	cathepsin B-like cysteine peptidase (Raphanus sativus)	53-81	N			Tsuji et al., 2008
73	ALE1 peptidase	53-81	P			Cedzich et al., 2009
73	SlSBT3 g.p. (Solanum lycopersicum)	53-81	N			Cedzich et al., 2009
73	Mername-AA083 peptidase	53-74	N		AA	Dal Degan et al., 1992
73	carboxypeptidase O	53-74	N			Dal Degan et al., 1992
73	tripeptidyl-peptidase I	71-81	P	normal turnover	MS	Vines & Warburton, 1998
74	Mername-AA083 peptidase	53-75	N		AA	Dal Degan et al., 1992
74	carboxypeptidase O	53-75	N			Dal Degan et al., 1992
75	cathepsin B-like cysteine peptidase (Raphanus sativus)	53-81	N			Tsuji et al., 2008
75	Mername-AA083 peptidase	53-76	N			Dal Degan et al., 1992
75	carboxypeptidase O	53-76	N		AA	Dal Degan et al., 1992
76	RD21 peptidase	53-81	N			Kikuchi et al., 2008
76	cathepsin B-like cysteine peptidase (Raphanus sativus)	53-81	N			Tsuji et al., 2008
76	ALE1 peptidase	53-81	P			Cedzich et al., 2009
76	SlSBT3 g.p. (Solanum lycopersicum)	53-81	N			Cedzich et al., 2009
76	Mername-AA083 peptidase	53-77	N			Dal Degan et al., 1992
76	carboxypeptidase O	53-77	N		AA	Dal Degan et al., 1992
76	tripeptidyl-peptidase I	74-81	P	normal turnover	MS	Vines & Warburton, 1998
77	Mername-AA083 peptidase	53-77	N		AA	Dal Degan et al., 1992
77	carboxypeptidase O	53-78	N		AA	Dal Degan et al., 1992
78	Mername-AA083 peptidase	53-79	N			Dal Degan et al., 1992
78	carboxypeptidase O	53-79	N			Dal Degan et al., 1992
79	cathepsin B-like cysteine peptidase (Raphanus sativus)	53-81	N			Tsuji et al., 2008
79	Mername-AA083 peptidase	53-80	N			Dal Degan et al., 1992
79	carboxypeptidase O	53-80	N			Dal Degan et al., 1992
79	tripeptidyl-peptidase I	77-81	P	normal turnover	MS	Vines & Warburton, 1998
80	Mername-AA083 peptidase	53-81	N		AA	Dal Degan et al., 1992
80	carboxypeptidase O	53-81	N			Dal Degan et al., 1992
83	PCSK1 peptidase	21-178	N
83	PCSK2 peptidase	21-178	P			<%Enzyme Nomenclature, 1996[]%>
89	unknown peptidase	1-180	P		NT	<%Agarwal et al., 2012[]%>
91	PCSK1 peptidase	21-178	N
97	PCSK1 peptidase	21-178	N
106	neprilysin	98-128	P		MS	Hupe-Sodmann et al., 1995
109	neprilysin	98-128	P		MS	Hupe-Sodmann et al., 1995
110	neprilysin	98-128	P		MS	Hupe-Sodmann et al., 1995
118	neprilysin	98-128	P		MS	Hupe-Sodmann et al., 1995
119	neprilysin	98-128	P		MS	Hupe-Sodmann et al., 1995
122	neprilysin	98-128	P		MS	Hupe-Sodmann et al., 1995
130	PCSK1 peptidase	21-178	N
145	PCSK1 peptidase	21-178	N