Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P08253

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
29	unknown peptidase	1-660	P		NT	<%Agarwal et al., 2012[]%>
66	membrane-type matrix metallopeptidase-1	30-660	P			Will et al., 1996
66	membrane-type matrix metallopeptidase-6	30-660	P			Nie & Pei, 2003
84	matrix metallopeptidase-3	18-476	P	normal turnover		Nagase et al., 1990
88	matrix metallopeptidase-2	110-660	P		MS	auf dem Keller et al., 2010
91	furin	18-477	P		CS	Cao et al., 2005
98	trypsin-2 type A	30-660	P			Sorsa et al., 1997
99	matrix metallopeptidase-3	18-477	P	normal turnover		<%Nagase et al., 1990[]%>
101	furin	30-660	P			Cao et al., 2005
101	PCSK2 peptidase	96-105	N		CS	Remacle et al., 2008
101	PCSK4 peptidase	96-105	N		CS	Remacle et al., 2008
101	PCSK6 peptidase	96-105	N		CS	Remacle et al., 2008
101	PCSK5 peptidase	96-105	N		CS	Remacle et al., 2008
101	PCSK7 peptidase	96-105	N		CS	Remacle et al., 2008
109	matrix metallopeptidase-2	30-660	P	release of an activation peptide		Crabbe et al., 1993
109	membrane-type matrix metallopeptidase-1	30-660	P			Pei & Weiss, 1996
109	membrane-type matrix metallopeptidase-6	30-660	P			Nie & Pei, 2003
129	matrix metallopeptidase-2	110-660	P		MS	auf dem Keller et al., 2010
149	matrix metallopeptidase-2	110-660	P		MS	auf dem Keller et al., 2010
161	matrix metallopeptidase-2	110-660	P		MS	auf dem Keller et al., 2010
193	matrix metallopeptidase-2	110-660	P		MS	auf dem Keller et al., 2010
197	matrix metallopeptidase-2	110-660	P		MS	auf dem Keller et al., 2010
204	matrix metallopeptidase-2	110-660	P		MS	auf dem Keller et al., 2010
336	elastase-2	110-660	P	normal turnover		Rice & Banda, 1995
358	matrix metallopeptidase-2	110-660	P		MS	auf dem Keller et al., 2010
359	matrix metallopeptidase-2	110-660	P		MS	auf dem Keller et al., 2010
379	elastase-2	110-660	P	normal turnover		Rice & Banda, 1995
444	unknown peptidase	1-660	P		NT	<%Agarwal et al., 2012[]%>
464	elastase-2	110-660	P			Rice & Banda, 1995
469	matrix metallopeptidase-2	110-660	P		MS	auf dem Keller et al., 2010
579	matrix metallopeptidase-2	110-660	P		MS	auf dem Keller et al., 2010