Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P01189

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
26	unknown peptidase	1-267	P	release of a signal peptide	NT	Zhang & Henzel, 2004
76	yapsin A	26-267	N			Loh & Cawley, 2004
137	yapsin A	26-267	N			Loh & Cawley, 2004
138	RD21 peptidase	138-162	N			Kikuchi et al., 2008
138	neprilysin	138-176	P		MS	Scholzen et al., 2007
138	aminopeptidase Ap1	138-176	N			Wilkes et al., 1973
138	acylaminoacyl-peptidase	138-150	N			Manning, 2004
139	pitrilysin	138-176	N			Cornista et al., 2004
139	aminopeptidase Ap1	139-176	N			Wilkes et al., 1973
139	penicillolysin	138-150	N			Ichishima, 2004
140	meprin alpha subunit	138-150	N			Bylander et al., 2007
140	aminopeptidase Ap1	140-176	N			Wilkes et al., 1973
140	unknown peptidase	138-150	N			Bertenshaw et al., 2001
141	aspergilloglutamic peptidase	138-161	N			O'Donoghue et al., 2008
141	oligopeptidase F	138-152	N		MS	Chao et al., 2006
141	meprin alpha subunit	138-150	N			Bylander et al., 2007
141	neprilysin	138-176	P		MS	Scholzen et al., 2007
141	aminopeptidase Ap1	141-176	N			Wilkes et al., 1973
142	neprilysin	138-150	P		MS	Scholzen et al., 2007
142	aspartyl aminopeptidase	142-147	N			Kelly et al., 1983
143	cathepsin B-like cysteine peptidase (Raphanus sativus)	138-176	N			Tsuji et al., 2008
143	oligopeptidase F	138-152	N		MS	Chao et al., 2006
143	neprilysin	138-150	P		MS	Scholzen et al., 2007
143	YMXG peptidase	138-150	N			Kitada et al., 2007
143	unknown peptidase	138-176	P		MS	Scholzen et al., 2007
144	cathepsin B-like cysteine peptidase (Raphanus sativus)	138-176	N			Tsuji et al., 2008
144	oligopeptidase F	138-152	N		MS	Chao et al., 2006
144	neprilysin	138-150	P		MS	Scholzen et al., 2007
144	YMXG peptidase	138-150	N			Kitada et al., 2007
144	penicillolysin	138-150	N			Ichishima, 2004
144	dipeptidyl-peptidase III	143-146	N			Chen & Barrett, 2004
144	unknown peptidase	138-176	P		MS	Scholzen et al., 2007
145	RD21 peptidase	138-162	N			Kikuchi et al., 2008
145	cathepsin B-like cysteine peptidase (Raphanus sativus)	138-176	N			Tsuji et al., 2008
145	neprilysin	138-150	P		MS	Scholzen et al., 2007
146	oligopeptidase F	138-152	N		MS	Chao et al., 2006
146	meprin alpha subunit	138-150	N			Bylander et al., 2007
146	neprilysin	138-176	P		MS	Scholzen et al., 2007
146	penicillolysin	138-150	N			Ichishima, 2004
147	oligopeptidase F	138-152	N		MS	Chao et al., 2006
147	meprin alpha subunit	138-150	P			Bertenshaw et al., 2001
147	unknown peptidase	138-176	P		MS	Scholzen et al., 2007
147	unknown peptidase	138-150	N			Bertenshaw et al., 2001
149	neprilysin	138-176	P		MS	Scholzen et al., 2007
149	prolyl oligopeptidase	138-150	N			Ito et al., 2004
150	aspergilloglutamic peptidase	138-161	N			O'Donoghue et al., 2008
151	RD21 peptidase	138-162	N			Kikuchi et al., 2008
151	cathepsin B-like cysteine peptidase (Raphanus sativus)	138-176	N			Tsuji et al., 2008
152	yapsin-1	138-176	N			Cawley & Loh, 2004
152	gingipain K	148-161	N			Pike et al., 1994
152	pitrilysin	138-176	N			Cornista et al., 2004
153	aspergilloglutamic peptidase	138-161	N			O'Donoghue et al., 2008
154	yapsin-1	138-176	N		AB	Azaryan et al., 1993
154	aspergilloglutamic peptidase	138-161	N			O'Donoghue et al., 2008
154	neprilysin	138-176	P		MS	Scholzen et al., 2007
155	furin	150-159	N		CS	Remacle et al., 2008
155	PCSK2 peptidase	150-159	N		CS	Remacle et al., 2008
155	PCSK4 peptidase	150-159	N		CS	Remacle et al., 2008
155	PCSK6 peptidase	150-159	N		CS	Remacle et al., 2008
155	PCSK5 peptidase	150-159	N		CS	Remacle et al., 2008
155	PCSK7 peptidase	150-159	N		CS	Remacle et al., 2008
156	neprilysin	138-176	P		MS	Scholzen et al., 2007
157	cathepsin B-like cysteine peptidase (Raphanus sativus)	138-176	N			Tsuji et al., 2008
158	RD21 peptidase	138-162	N			Kikuchi et al., 2008
158	cathepsin B-like cysteine peptidase (Raphanus sativus)	138-176	N			Tsuji et al., 2008
158	gingipain K	148-161	N			Pike et al., 1994
158	neprilysin	138-176	P		MS	Scholzen et al., 2007
159	cathepsin B-like cysteine peptidase (Raphanus sativus)	138-176	N			Tsuji et al., 2008
162	neprilysin	138-176	P		MS	Scholzen et al., 2007
166	aspergilloglutamic peptidase	155-176	N			O'Donoghue et al., 2008
167	aspergilloglutamic peptidase	155-176	N			O'Donoghue et al., 2008
172	aspergilloglutamic peptidase	155-176	N			O'Donoghue et al., 2008
177	yapsin A	26-267	N			Loh & Cawley, 2004
178	yapsin A	26-267	N			Loh & Cawley, 2004
178	furin	173-182	N		CS	Remacle et al., 2008
178	PCSK2 peptidase	173-182	N		CS	Remacle et al., 2008
178	PCSK4 peptidase	173-182	N		CS	Remacle et al., 2008
178	PCSK6 peptidase	173-182	N		CS	Remacle et al., 2008
178	PCSK5 peptidase	173-182	N		CS	Remacle et al., 2008
178	PCSK7 peptidase	173-182	N		CS	Remacle et al., 2008
205	dibasic processing endopeptidase (unsequenced)	179-267	P		NT	Loh, 1986
215	yapsin-1	179-267	N		NT	Azaryan et al., 1993
218	dipeptidyl-peptidase I	217-234	P		NT	Hsiung et al., 2005
218	dipeptidyl-peptidase IV (eukaryote)	217-234	P		NT	Hsiung et al., 2005
220	dipeptidyl-peptidase I	217-234	P		NT	Hsiung et al., 2005
220	dipeptidyl-peptidase IV (eukaryote)	217-234	P		NT	Hsiung et al., 2005
235	yapsin-1	179-267	N		AB	Azaryan et al., 1993
235	dibasic processing endopeptidase (unsequenced)	179-267	P		NT	Loh, 1986
236	yapsin A	26-267	N			Loh & Cawley, 2004
236	aminopeptidase B	236-241	N			Foulon et al., 2004
236	furin	231-240	N		CS	Remacle et al., 2008
236	PCSK2 peptidase	231-240	N		CS	Remacle et al., 2008
236	PCSK4 peptidase	231-240	N		CS	Remacle et al., 2008
236	PCSK6 peptidase	231-240	N		CS	Remacle et al., 2008
236	PCSK5 peptidase	231-240	N		CS	Remacle et al., 2008
236	PCSK7 peptidase	231-240	N		CS	Remacle et al., 2008
237	aminopeptidase N	237-241	N			Turner, 2004
237	leukotriene A4 hydrolase	237-241	N			Griffin et al., 1992
237	cytosol alanyl aminopeptidase	237-241	N			Hui et al., 1998
237	aminopeptidase S (Staphylococcus-type)	237-241	N			Odintsov et al., 2005
237	neuron-specific aminopeptidase	237-241	N			Hui et al., 1998
237	neuron-specific aminopeptidase-2	237-241	N			Hui et al., 2008
238	oligopeptidase E	237-241	N			Fenster et al., 2004
238	aminopeptidase S (Staphylococcus-type)	238-241	N			Odintsov et al., 2005
239	cathepsin B	237-241	N			Takahashi et al., 1986
239	oligopeptidase E	237-241	N			Chapot-Chartier & Mistou, 2004
239	peptidyl-dipeptidase Acer	237-241	N			Isaac, 2004
239	ruberlysin	237-241	N			Tu, 2004
239	oligopeptidase O3	237-241	N			Meyer et al., 2004
239	eupitrilysin	237-267	N			Chow et al., 2009
239	tripeptidyl-peptidase I	237-253	N			Oyama et al., 2005
239	unknown peptidase	237-241	N			Corvol et al., 2004
240	eupitrilysin	237-267	N			Chow et al., 2009
245	yapsin-3	237-265	N		NT	Olsen et al., 1999
245	gingipain K	237-267	N			Pike et al., 1994
251	eupitrilysin	237-267	N			Chow et al., 2009
252	eupitrilysin	237-267	N			Chow et al., 2009
253	cathepsin D	237-267	N			Kageyama et al., 1995
253	cathepsin E	237-267	N			Kageyama et al., 1995
253	insulysin	237-267	N			Cornista et al., 2004
253	eupitrilysin	237-267	N			Chow et al., 2009
254	pitrilysin	237-267	N			Cornista et al., 2004
254	insulysin	237-267	N			Cornista et al., 2004
255	gingipain K	237-267	N			Pike et al., 1994
255	pitrilysin	237-267	N			Cornista et al., 2004
257	eupitrilysin	237-267	N			Chow et al., 2009
260	gingipain K	237-267	N			Pike et al., 1994
264	yapsin-1	237-267	N			Cawley et al., 1996
264	gingipain K	237-267	N			Pike et al., 1994
266	insect gut carboxypeptidase-2	237-267	N			Bown & Gatehouse, 2004