Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P04070

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
18	unknown peptidase	1-461	P		NT	<%Agarwal et al., 2012[]%>
42	russellysin	33-461	N			Kawabata & Iwanaga, 2004
42	furin	33-461	P			Drews et al., 1995
197	unknown peptidase	1-461	P		NT	<%Agarwal et al., 2012[]%>
199	furin	43-461	P			Drews et al., 1995
199	PCSK2 peptidase	194-203	N		CS	Remacle et al., 2008
199	PCSK4 peptidase	194-203	N		CS	Remacle et al., 2008
199	PCSK6 peptidase	194-203	N		CS	Remacle et al., 2008
199	PCSK5 peptidase	194-203	N		CS	Remacle et al., 2008
199	PCSK7 peptidase	194-203	N		CS	Remacle et al., 2008
211	thrombin	43-461	P	release of an activation peptide		Hackeng et al., 1996
211	kallikrein-related peptidase 4	1-461	P		CS	Matsumura et al., 2005