Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P01350

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
21	unknown peptidase	1-101	P	release of a signal peptide	NT	Rehfeld & Johnsen, 1994
40	unknown peptidase	1-101	P		NT	<%Agarwal et al., 2012[]%>
58	furin	53-62	N		CS	Remacle et al., 2008
58	PCSK1 peptidase	22-101	P	release of a bioactive peptide	NT	Sawada et al., 2000
58	PCSK2 peptidase	53-62	N		CS	Remacle et al., 2008
58	PCSK4 peptidase	53-62	N		CS	Remacle et al., 2008
58	PCSK6 peptidase	53-62	N		CS	Remacle et al., 2008
58	PCSK5 peptidase	53-62	N		CS	Remacle et al., 2008
58	PCSK7 peptidase	53-62	N		CS	Remacle et al., 2008
75	PCSK1 peptidase	59-101	P	release of a bioactive peptide	NT	Sawada et al., 2000
75	PCSK2 peptidase	22-101	P			Dickinson et al., 1995
79	neprilysin	76-92	P			Pauwels et al., 1989
80	meprin beta subunit	76-92	N			Bertenshaw et al., 2001
81	meprin beta subunit	76-92	N			Bertenshaw et al., 2001
82	meprin beta subunit	76-92	N			Bertenshaw et al., 2001
83	meprin beta subunit	76-92	N			Bertenshaw et al., 2001
86	neprilysin	76-92	P			Pauwels et al., 1989
88	neprilysin	76-92	P			Pauwels et al., 1989
89	aminopeptidase Ap1	89-92	N			Wilkes et al., 1973
89	serine carboxypeptidase Z (Absidia zachae) and similar	89-90	N		AA	Lee et al., 1993
90	aminopeptidase Ap1	90-92	N			Wilkes et al., 1973
90	serine carboxypeptidase Z (Absidia zachae) and similar	89-91	N		AA	Lee et al., 1993
91	neprilysin	76-92	P			Pauwels et al., 1989
91	serine carboxypeptidase Z (Absidia zachae) and similar	89-92	N		AA	Lee et al., 1993
91	carboxypeptidase O	89-92	N		AA	Lee et al., 1993
93	carboxypeptidase E	59-94	P		NT	Sawada et al., 2000
94	carboxypeptidase E	59-95	P		NT	Sawada et al., 2000
95	PCSK1 peptidase	22-101	P	release of an activation peptide	NT	Sawada et al., 2000