Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence O00253

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
20	unknown peptidase	1-132	P		NT	<%Agarwal et al., 2012[]%>
82	PCSK1 peptidase	21-132	P			Creemers et al., 2006
82	PCSK2 peptidase	21-132	P			Creemers et al., 2006
82	PCSK5 peptidase	21-132	P			Creemers et al., 2006
85	PCSK1 peptidase	21-132	P			Creemers et al., 2006