Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P50281

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
20	unknown peptidase	1-582	P		NT	<%Agarwal et al., 2012[]%>
49	matrix metallopeptidase-2	21-582	P			Golubkov et al., 2007
49	membrane-type matrix metallopeptidase-1	21-582	P			Golubkov et al., 2007
60	matrix metallopeptidase-2	21-582	P			Golubkov et al., 2007
60	membrane-type matrix metallopeptidase-1	21-582	P			Golubkov et al., 2007
78	peptidyl-Lys metallopeptidase	1-582	N		MS
103	peptidyl-Lys metallopeptidase	1-582	N		MS
108	plasmin	21-582	P			Okumura et al., 1997
111	membrane-type matrix metallopeptidase-1	21-582	P			Rozanov & Strongin, 2003
111	plasmin	21-582	P			Okumura et al., 1997
111	furin	21-582	P			Sato et al., 1996
111	PCSK2 peptidase	106-115	N		CS	Remacle et al., 2008
111	PCSK4 peptidase	106-115	N		CS	Remacle et al., 2008
111	PCSK6 peptidase	106-115	N		CS	Remacle et al., 2008
111	PCSK5 peptidase	106-115	N		CS	Remacle et al., 2008
111	PCSK7 peptidase	106-115	N		CS	Remacle et al., 2008
118	membrane-type matrix metallopeptidase-1	112-582	P			Rozanov & Strongin, 2003
129	membrane-type matrix metallopeptidase-1	112-582	P			Rozanov & Strongin, 2003
221	membrane-type matrix metallopeptidase-1	112-582	P			Rozanov & Strongin, 2003
255	membrane-type matrix metallopeptidase-1	1-582	P			Toth et al., 2002
283	membrane-type matrix metallopeptidase-1	112-582	P			Rozanov & Strongin, 2003
284	membrane-type matrix metallopeptidase-1	1-582	P			<%Hernandez-Barrantes et al., 2000[]%>
298	membrane-type matrix metallopeptidase-1	112-582	P			Rozanov & Strongin, 2003