Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P03956

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
19	unknown peptidase	1-469	P		NT	<%Agarwal et al., 2012[]%>
25	meprin alpha subunit	100-469	N		MS	Becker-Pauly et al., 2011
27	meprin beta subunit	20-469	N		MS	Becker-Pauly et al., 2011
54	plasma kallikrein	20-469	P			Suzuki et al., 1991
55	trypsin 1	20-469	P			Suzuki et al., 1991
83	matrix metallopeptidase-1	20-469	P	normal turnover		Desrochers et al., 1991
86	matrix metallopeptidase-1	20-469	P			<%Suzuki et al., 1991[]%>
91	PCSK2 peptidase	86-95	N		CS	Remacle et al., 2008
91	PCSK4 peptidase	86-95	N		CS	Remacle et al., 2008
91	PCSK6 peptidase	86-95	N		CS	Remacle et al., 2008
91	PCSK5 peptidase	86-95	N		CS	Remacle et al., 2008
91	PCSK7 peptidase	86-95	N		CS	Remacle et al., 2008
99	matrix metallopeptidase-1	20-469	P	release of an activation peptide		Desrochers et al., 1991
99	matrix metallopeptidase-3	20-469	P	release of an activation peptide		Suzuki et al., 1991
99	matrix metallopeptidase-7	20-469	P	release of an activation peptide		Abramson et al., 1995
99	plasmin	20-469	P			Cawston, 2004
100	matrix metallopeptidase-1	20-469	P	conversion to two-chain form		Desrochers et al., 1991
101	thermolysin	20-469	N			Okamoto et al., 1997
101	vibriolysin	20-469	N			Okamoto et al., 1997
101	pseudolysin	20-469	N			Okamoto et al., 1997
101	matrix metallopeptidase-1	20-469	P			Desrochers et al., 1991
102	chymase (Homo sapiens-type)	20-469	P			Raymond et al., 2003
184	meprin alpha subunit	100-469	N		MS	Becker-Pauly et al., 2011
184	meprin beta subunit	100-469	N		MS	Becker-Pauly et al., 2011
269	thermolysin	100-469	N			Okamoto et al., 1997
269	vibriolysin	100-469	N			Okamoto et al., 1997
269	pseudolysin		N			Okamoto et al., 1997
269	matrix metallopeptidase-1	100-469	P	conversion to two-chain form		Desrochers et al., 1991