Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P01210

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
24	unknown peptidase	1-267	P		NT	<%Agarwal et al., 2012[]%>
102	neprilysin	101-104	N		NT	Rose et al., 2002
102	neprilysin-2	100-104	N		NT	Rose et al., 2002
103	carboxypeptidase A4	100-104	N			Tanco et al., 2010
103	carboxypeptidase A6	100-104	P		MS	Lyons et al., 2008
113	yapsin-1	107-119	P		NT	Cawley et al., 1996
142	furin	137-146	N		CS	Remacle et al., 2008
142	PCSK1 peptidase	25-267	P			Seidah & Chretien, 1994
142	PCSK2 peptidase	137-146	N		CS	Remacle et al., 2008
142	PCSK4 peptidase	137-146	N		CS	Remacle et al., 2008
142	PCSK6 peptidase	137-146	N		CS	Remacle et al., 2008
142	PCSK5 peptidase	137-146	N		CS	Remacle et al., 2008
142	PCSK7 peptidase	137-146	N		CS	Remacle et al., 2008
185	PCSK1 peptidase	25-267	P			Seidah & Chretien, 1994
185	PCSK2 peptidase	25-267	P			Seidah & Chretien, 1994
191	cathepsin B	186-193	N			Takahashi et al., 1986
194	unknown peptidase	25-267	P			Hook, 2004
195	furin	190-199	N		CS	Remacle et al., 2008
195	PCSK1 peptidase	25-267	P			Seidah & Chretien, 1994
195	PCSK2 peptidase	190-199	N		CS	Remacle et al., 2008
195	PCSK4 peptidase	190-199	N		CS	Remacle et al., 2008
195	PCSK6 peptidase	190-199	N		CS	Remacle et al., 2008
195	PCSK5 peptidase	190-199	N		CS	Remacle et al., 2008
195	PCSK7 peptidase	190-199	N		CS	Remacle et al., 2008
207	unknown peptidase	1-267	P		NT	<%Agarwal et al., 2012[]%>
213	carboxypeptidase A6	210-214	P		NT	Lyons & Fricker, 2010
226	carboxypeptidase A6	217-227	N			Lyons & Fricker, 2010
227	unknown peptidase	1-267	P		NT	<%Agarwal et al., 2012[]%>
229	PCSK1 peptidase	25-267	P			Seidah & Chretien, 1994
229	PCSK2 peptidase	25-267	P			Seidah & Chretien, 1994
232	oligopeptidase E	230-234	N			Fenster et al., 2004
232	neprilysin-2	230-234	N		NT	Rose et al., 2002
233	carboxypeptidase A6	230-234	P			Lyons & Fricker, 2010
236	furin	231-240	N		CS	Remacle et al., 2008
236	PCSK1 peptidase	25-267	P			Seidah & Chretien, 1994
236	PCSK2 peptidase	25-267	P			Seidah & Chretien, 1994
260	PCSK1 peptidase	25-267	P			Seidah & Chretien, 1994
260	PCSK2 peptidase	25-267	P			Seidah & Chretien, 1994
265	cathepsin B	261-267	N			Takahashi et al., 1986
266	carboxypeptidase A4	261-267	N			Tanco et al., 2010
266	carboxypeptidase A6	261-267	P		NT	Lyons & Fricker, 2010