Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P60042

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
24	unknown peptidase	1-116	P	release of a signal peptide	NT	Benoit et al., 1987
35	site-1 peptidase	89-116	P		-	Pasquato et al., 2006
88	unknown peptidase	1-116	P		NT	<%Agarwal et al., 2012[]%>
102	PCSK1 peptidase	25-116	P			Seidah & Chretien, 1994
102	PCSK2 peptidase	25-116	P			Seidah & Chretien, 1994