Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P21754

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
22	unknown peptidase	1-424	P		NT	<%Agarwal et al., 2012[]%>
350	unknown peptidase	1-424	P		NT	<%Agarwal et al., 2012[]%>
352	furin	23-350	N			Kiefer & Saling, 2002
352	PCSK2 peptidase	347-356	N		CS	Remacle et al., 2008
352	PCSK4 peptidase	347-356	N		CS	Remacle et al., 2008
352	PCSK6 peptidase	347-356	N		CS	Remacle et al., 2008
352	PCSK5 peptidase	347-356	N		CS	Remacle et al., 2008
352	PCSK7 peptidase	347-356	N		CS	Remacle et al., 2008