Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P12272

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
24	unknown peptidase	1-177	P		NT	<%Agarwal et al., 2012[]%>
34	unknown peptidase	1-177	P		NT	<%Agarwal et al., 2012[]%>
36	kallikrein-related peptidase 4	1-177	P		CS	Matsumura et al., 2005
36	furin	31-40	N		CS	Remacle et al., 2008
36	PCSK2 peptidase	31-40	N		CS	Remacle et al., 2008
36	PCSK4 peptidase	31-40	N		CS	Remacle et al., 2008
36	PCSK6 peptidase	31-40	N		CS	Remacle et al., 2008
36	PCSK5 peptidase	31-40	N		CS	Remacle et al., 2008
36	PCSK7 peptidase	31-40	N		CS	Remacle et al., 2008
59	kallikrein-related peptidase 3	37-177	P			<%Cramer et al., 1996[]%>
60	cathepsin B	58-75	N		MS	Biniossek et al., 2011
62	meprin alpha subunit	37-177	N		MS	Becker-Pauly et al., 2011
62	meprin beta subunit	37-177	N		MS	Becker-Pauly et al., 2011
148	PHEX peptidase	143-175	N		MS	Boileau et al., 2001
163	PHEX peptidase	143-175	N		MS	Boileau et al., 2001
172	PHEX peptidase	143-175	N		MS	Boileau et al., 2001