Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P16860

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
26	unknown peptidase	1-134	P	release of a signal peptide	NT	Hino et al., 1990
102	furin	27-134	P			Sawada et al., 1997
102	PCSK2 peptidase	97-106	N		CS	Remacle et al., 2008
102	PCSK4 peptidase	97-106	N		CS	Remacle et al., 2008
102	PCSK6 peptidase	97-106	N		CS	Remacle et al., 2008
102	PCSK5 peptidase	97-106	N		CS	Remacle et al., 2008
102	PCSK7 peptidase	97-106	N		CS	Remacle et al., 2008
106	neprilysin	103-134	P			Watanabe et al., 1997
108	meprin alpha subunit	103-134	P		LC	Pankow et al., 2007
109	meprin alpha subunit	103-134	P		LC	Pankow et al., 2007
119	neprilysin	103-134	P			Watanabe et al., 1997