Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P01137

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
29	unknown peptidase	1-390	P	release of a signal peptide	NT	Miyazono et al., 1988
278	kallikrein-related peptidase 4	1-390	P		CS	Matsumura et al., 2005
278	furin	30-390	P			Dubois et al., 1995
278	PCSK2 peptidase	273-282	N		CS	Remacle et al., 2008
278	PCSK4 peptidase	273-282	N		CS	Remacle et al., 2008
278	PCSK6 peptidase	273-282	N		CS	Remacle et al., 2008
278	PCSK5 peptidase	273-282	N		CS	Remacle et al., 2008
278	PCSK7 peptidase	273-282	N		CS	Remacle et al., 2008