Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P46531

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
18	unknown peptidase	1-2555	P		NT	<%Agarwal et al., 2012[]%>
1664	PCSK2 peptidase	1659-1668	N		CS	Remacle et al., 2008
1664	PCSK4 peptidase	1659-1668	N		CS	Remacle et al., 2008
1664	PCSK6 peptidase	1659-1668	N		CS	Remacle et al., 2008
1664	PCSK5 peptidase	1659-1668	N		CS	Remacle et al., 2008
1664	PCSK7 peptidase	1659-1668	N		CS	Remacle et al., 2008
1720	unknown peptidase	1-2555	P		NT	<%Agarwal et al., 2012[]%>
1753	unknown peptidase	1-2555	P		NT	<%Agarwal et al., 2012[]%>
1754	presenilin 1	19-2556	P	release from a membrane surface		Lee et al., 2002
1754	ADAM17 peptidase	19-2555	P			<%Schroeter et al., 1998[]%>
1756	BACE2 g.p. (Homo sapiens)	1750-1759	P		MS	Kim et al., 2002
1757	BACE2 g.p. (Homo sapiens)	1750-1759	P		MS	Kim et al., 2002
1833	granzyme B (Homo sapiens-type)	19-2555	P		CS	Loeb et al., 2006
1839	caspase-3	19-2555	P			Cohen et al., 2005
1871	granzyme B (Homo sapiens-type)	19-2555	P		CS	Loeb et al., 2006
1873	caspase-6	19-2555	P			Cohen et al., 2005
1905	caspase-6	19-2555	P			Cohen et al., 2005
1912	granzyme B (Homo sapiens-type)	19-2555	P		CS	Loeb et al., 2006
1972	granzyme B (Homo sapiens-type)	19-2555	P		CS	Loeb et al., 2006
2082	granzyme B (Homo sapiens-type)	19-2555	P		CS	Loeb et al., 2006
2094	caspase-6	19-2555	P			Cohen et al., 2005
2192	caspase-6	19-2555	P			Cohen et al., 2005