Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P22005

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
24	unknown peptidase	1-268	P		NT	<%Agarwal et al., 2012[]%>
186	PCSK2 peptidase	25-268	P		MS	Pan et al., 2006
196	PCSK2 peptidase	25-268	P		MS	Pan et al., 2006
197	PCSK2 peptidase	25-268	P		MS	Pan et al., 2006
208	unknown peptidase	1-268	P		NT	<%Agarwal et al., 2012[]%>
210	PCSK2 peptidase	25-268	P		MS	Pan et al., 2006
217	PCSK2 peptidase	25-268	P		MS	Pan et al., 2006
228	unknown peptidase	1-268	P		NT	<%Agarwal et al., 2012[]%>
230	PCSK2 peptidase	25-268	P		MS	Pan et al., 2006
238	PCSK2 peptidase	25-268	P		MS	Pan et al., 2006
261	PCSK2 peptidase	25-268	P		MS	Pan et al., 2006
268	carboxypeptidase A4	263-269	P		MS	Tanco et al., 2010