Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P05408

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
26	unknown peptidase	1-211	P	release of a signal peptide	NT	Seidah et al., 1983
176	unknown peptidase	1-212	P		NT	<%Agarwal et al., 2012[]%>
181	furin	27-212	P			Hwang et al., 2001
181	PCSK2 peptidase	176-185	N		CS	Remacle et al., 2008
181	PCSK4 peptidase	176-185	N		CS	Remacle et al., 2008
181	PCSK6 peptidase	176-185	N		CS	Remacle et al., 2008
181	PCSK5 peptidase	176-185	N		CS	Remacle et al., 2008
181	PCSK7 peptidase	176-185	N		CS	Remacle et al., 2008
199	PCSK2 peptidase	27-212	P			Zhu et al., 1996