Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence O95450

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
29	unknown peptidase	1-1211	P		NT	<%Agarwal et al., 2012[]%>
88	furin	82-92	N		CS	Remacle et al., 2008
88	PCSK2 peptidase	82-92	N		CS	Remacle et al., 2008
88	PCSK4 peptidase	82-92	N		CS	Remacle et al., 2008
88	PCSK6 peptidase	82-92	N		CS	Remacle et al., 2008
88	PCSK5 peptidase	82-92	N		CS	Remacle et al., 2008
88	PCSK7 peptidase	82-92	N		CS	Remacle et al., 2008
253	unknown peptidase	1-1211	P		NT	<%Agarwal et al., 2012[]%>
259	furin	254-263	N		CS	Remacle et al., 2008
259	PCSK4 peptidase	254-263	N		CS	Remacle et al., 2008
259	PCSK6 peptidase	254-263	N		CS	Remacle et al., 2008
259	PCSK5 peptidase	254-263	N		CS	Remacle et al., 2008
259	PCSK7 peptidase	254-263	N		CS	Remacle et al., 2008
606	unknown peptidase	1-1211	P		MS	Van Damme et al., 2005