Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P08648

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
41	unknown peptidase	1-1049	P	release of a signal peptide	NT	Takada et al., 1987
894	furin	889-898	N		CS	Remacle et al., 2008
894	PCSK2 peptidase	889-898	N		CS	Remacle et al., 2008
894	PCSK4 peptidase	889-898	N		CS	Remacle et al., 2008
894	PCSK6 peptidase	889-898	N		CS	Remacle et al., 2008
894	PCSK5 peptidase	889-898	N		CS	Remacle et al., 2008
894	PCSK7 peptidase	889-898	N		CS	Remacle et al., 2008