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Display Known Cleavages for a Protein

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Accession:

Sequence P01308

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
24	unknown peptidase	1-110	P	release of a signal peptide	NT	Nicol & Smith, 1960
25	jerdohagin (Trimeresurus jerdonii)	25-54	N		MS	Chen et al., 2004
26	jerdohagin (Trimeresurus jerdonii)	25-54	N		MS	Chen et al., 2004
27	matrix metallopeptidase-9	25-54,90-110	P	release of an amino acid		Deschamps et al., 2002
28	ammodytase	25-54	N		NT	Leonardi et al., 2007
29	matrix metallopeptidase-9	25-54,90-110	P	release of an amino acid		Deschamps et al., 2002
29	meprin alpha subunit	25-54	N			Butler et al., 1987
29	jerdohagin (Trimeresurus jerdonii)	25-54	N		MS	Chen et al., 2004
29	ALE1 peptidase	25-54	N			Cedzich et al., 2009
30	meprin alpha subunit	25-54	N			Butler et al., 1987
30	jerdohagin (Trimeresurus jerdonii)	25-54	N		MS	Chen et al., 2004
32	meprin alpha subunit	25-54	N			Butler et al., 1987
33	jerdohagin (Trimeresurus jerdonii)	25-54	N		MS	Chen et al., 2004
33	insulysin	25-54,90-110	P		MS	Guo et al., 2009
34	matrix metallopeptidase-9	25-54,90-110	P	normal turnover		Deschamps et al., 2002
34	meprin alpha subunit	25-54	N			Butler et al., 1987
34	subfamily M12B unassigned peptidases	25-54	N		NT	Leonardi et al., 2002
34	insulysin	25-54,90-110	P		MS	Guo et al., 2009
35	cathepsin E	25-54	N			Athauda et al., 1992
35	jerdohagin (Trimeresurus jerdonii)	25-54	N		MS	Chen et al., 2004
35	CDF peptidase	25-54	N			Cheng et al., 2009
37	cathepsin E	25-54	N			Athauda et al., 1992
37	insulysin	25-54,90-110	P		MS	Guo et al., 2009
38	cathepsin E	25-54	N			Athauda et al., 1992
38	matrix metallopeptidase-9	25-54,90-110	P	normal turnover		Deschamps et al., 2002
38	meprin alpha subunit	25-54	N			Butler et al., 1987
38	subfamily M12B unassigned peptidases	25-54	N		NT	Leonardi et al., 2002
38	insulysin	25-54,90-110	P		MS	Guo et al., 2009
39	cathepsin E	25-54	N			Athauda et al., 1992
39	meprin alpha subunit	25-54	N			Butler et al., 1987
39	duodenase	25-54	N		NT	Pemberton et al., 1997
39	CDF peptidase	25-54	N			Cheng et al., 2009
40	cathepsin E	25-54	N			Athauda et al., 1992
40	matrix metallopeptidase-9	25-54; 90-110	P	normal turnover		Deschamps et al., 2002
40	ammodytase	25-54	N		NT	Leonardi et al., 2007
40	jerdohagin (Trimeresurus jerdonii)	25-54	N		MS	Chen et al., 2004
40	subfamily M12B unassigned peptidases	25-54	N		NT	Leonardi et al., 2002
41	cathepsin E	25-54	N			Athauda et al., 1992
41	meprin alpha subunit	25-54	N			Butler et al., 1987
41	jerdohagin (Trimeresurus jerdonii)	25-54	N		MS	Chen et al., 2004
42	jerdohagin (Trimeresurus jerdonii)	25-54	N		MS	Chen et al., 2004
42	ALE1 peptidase	25-54	N			Cedzich et al., 2009
43	jerdohagin (Trimeresurus jerdonii)	25-54	N		MS	Chen et al., 2004
43	ALE1 peptidase	25-54	N			Cedzich et al., 2009
44	matrix metallopeptidase-9	25-54; 90-110	P	normal turnover		Deschamps et al., 2002
44	meprin alpha subunit	25-54	N			Butler et al., 1987
44	jerdohagin (Trimeresurus jerdonii)	25-54	N		MS	Chen et al., 2004
45	cathepsin E	25-54	N			Athauda et al., 1992
46	jerdohagin (Trimeresurus jerdonii)	25-54	N		MS	Chen et al., 2004
47	matrix metallopeptidase-9	25-54; 90-110	P	normal turnover		Deschamps et al., 2002
47	jerdohagin (Trimeresurus jerdonii)	25-54	N		MS	Chen et al., 2004
48	cathepsin E	25-54	N			Athauda et al., 1992
48	meprin alpha subunit	25-54	N			Butler et al., 1987
48	insulysin	25-54,90-110	P		MS	Guo et al., 2009
48	CDF peptidase	25-54	N			Cheng et al., 2009
49	cathepsin E	25-54	N			Athauda et al., 1992
49	meprin alpha subunit	25-54	N			Butler et al., 1987
49	jerdohagin (Trimeresurus jerdonii)	25-54	N		MS	Chen et al., 2004
49	insulysin	25-54,90-110	P		MS	Guo et al., 2009
52	jerdohagin (Trimeresurus jerdonii)	25-54	N		MS	Chen et al., 2004
54	carboxypeptidase E	25-55	P			Goodge & Hutton, 2000
55	carboxypeptidase E	25-56	P			Goodge & Hutton, 2000
55	dibasic processing endopeptidase (unsequenced)	25-110	P		NT	Docherty et al., 1989
56	yapsin-1	25-110	P			Cawley & Loh, 2004
56	yapsin A	25-110	N			Loh & Cawley, 2004
56	PCSK1 peptidase	25-110	P			Seidah & Chretien, 1994
87	carboxypeptidase E	57-88	P			Goodge & Hutton, 2000
88	carboxypeptidase E	57-89	P			Goodge & Hutton, 2000
88	dibasic processing endopeptidase (unsequenced)	25-110	P		NT	Docherty et al., 1989
89	yapsin A	25-110	N			Loh & Cawley, 2004
89	aminopeptidase B	25-54,89-110	P		MS	Kouach et al., 2009
89	PCSK1 peptidase	25-110	P			Seidah & Chretien, 1994
89	PCSK2 peptidase	25-110	P			Seidah & Chretien, 1994
101	matrix metallopeptidase-9	25-54; 90-110	P	normal turnover		Deschamps et al., 2002
102	insulysin	25-54,90-110	P		MS	Guo et al., 2009
103	insulysin	25-54,90-110	P		MS	Guo et al., 2009
104	matrix metallopeptidase-9	25-54; 90-110	P	normal turnover		Deschamps et al., 2002
106	matrix metallopeptidase-9	25-54; 90-110	P	normal turnover		Deschamps et al., 2002