Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence Q99075

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
19	unknown peptidase	1-208	P		NT	<%Agarwal et al., 2012[]%>
31	ADAM17 peptidase	20-208	P			Hinkle et al., 2004
62	ADAM17 peptidase	20-208	P			Hinkle et al., 2004
62	furin	57-66	N		CS	Remacle et al., 2008
62	PCSK2 peptidase	57-66	N		CS	Remacle et al., 2008
62	PCSK4 peptidase	57-66	N		CS	Remacle et al., 2008
62	PCSK6 peptidase	57-66	N		CS	Remacle et al., 2008
62	PCSK5 peptidase	57-66	N		CS	Remacle et al., 2008
62	PCSK7 peptidase	57-66	N		CS	Remacle et al., 2008
72	ADAM17 peptidase	20-208	P			Hinkle et al., 2004
73	ADAM17 peptidase	20-208	P			Hinkle et al., 2004
148	unknown peptidase	1-208	P		NT	<%Agarwal et al., 2012[]%>
149	membrane-type matrix metallopeptidase-1	20-208	P			Amour et al., 2002
149	ADAM17 peptidase	20-208	P			Hinkle et al., 2004
151	matrix metallopeptidase-3	20-208	P	normal turnover		Suzuki et al., 1998
151	membrane-type matrix metallopeptidase-1	20-208	P			Amour et al., 2002
151	membrane-type matrix metallopeptidase-4	20-208	P			Amour et al., 2002
153	membrane-type matrix metallopeptidase-4	20-208	P			Amour et al., 2002